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Compound dry suspension preparation containing omeprazole and sodium bicarbonate

A technology of sodium bicarbonate and omeprazole, which is applied in the field of medicine, can solve problems such as difficulty in taking it, increasing production costs, and slowing down of drug onset, and achieves a low-impurity, short-production cycle, and strong controllability. Effect

Inactive Publication Date: 2013-04-24
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is a capsule dosage form of compound omeprazole on the market in foreign countries, the specification of sodium bicarbonate reaches 1.1g / capsule, and the prepared capsules are relatively large, so it is difficult to be suitable for some patients with swallowing disorders and elderly and children patients.
In order to avoid the decomposition and damage of gastric juice, the existing proton pump inhibitors are mostly oral enteric-coated preparations, which need to be coated with enteric coating during production. This design has several disadvantages: ① Special coating equipment is required in the production process , the process requirements are high, which increases the production cost; ②Most enteric-coated preparations are moisture-sensitive; ③Due to the release in the intestinal juice, the onset of the drug slows down and the time to peak is delayed

Method used

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  • Compound dry suspension preparation containing omeprazole and sodium bicarbonate
  • Compound dry suspension preparation containing omeprazole and sodium bicarbonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Numbering

Embodiment 2

0.83

[0030] Preparation process: mix omeprazole and an equal amount of sodium bicarbonate evenly, fully mix the aforementioned mixture with sucrose, xylitol, sucralose, essence, xanthan gum and the remaining sodium bicarbonate, pack into bags, Instantly. Three batches of samples were prepared from Example 1 and Example 2 respectively.

[0031] result:

[0032]

[0033] Note: The result of acid resistance greater than 90% is qualified, and the dissolution rate is greater than 80% within 30 minutes.

Embodiment 3

[0034] Example 3 Compound Omeprazole Dry Suspension and Pair Omeprazole Enteric-Coated Capsules to the Treatment of Peptic Ulcer

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Abstract

A compound dry suspension preparation containing omeprazole and sodium bicarbonate is characterized in that the sodium bicarbonate is adopted as buffer agent, and xanthan gum is adopted as suspending agent. The invention further relates to a preparation technique which relates to the particle size of xanthan gum.

Description

technical field [0001] This article provides a compound dry suspension preparation comprising omeprazole and sodium bicarbonate, wherein xanthan gum is used as a suspending agent in the formulation, and belongs to the technical field of medicine. Background technique [0002] Digestive system disease is a kind of frequently-occurring disease common in people's daily life. According to statistics, the incidence of gastrointestinal diseases in the world accounts for about 12% of the population, and the incidence of digestive system in China is also increasing year by year. At present, sales of digestive system drugs in China rank among the top three in various drug categories. In 2003, the annual sales of digestive system drugs in China reached 26.7 billion yuan, accounting for about 15% of drug sales. Among the drugs for the entire digestive system, drugs for the treatment of peptic ulcer accounted for the highest proportion, reaching 59%. According to the sample survey dat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/14A61K9/16A61K9/20A61K9/48A61K47/36A61K47/40A61K47/42A61P1/04A61K31/4439
Inventor 不公告发明人
Owner FUKANGREN BIO PHARMA
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