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Surface-modified artificial lens with coating layer carrying drug and preparation method thereof

An intraocular lens and surface modification technology, applied in the field of surface modification of biomedical materials, can solve problems such as failure to achieve long-term application, secondary cataracts, easy to cause inflammation, etc., to achieve convenient operation, resistance to cell differentiation and proliferation, resistance to The effect of platelet adhesion

Active Publication Date: 2014-05-07
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the modification model currently studied is only modified by physical factors such as increasing hydrophilicity or charge polarity, which can achieve anti-adhesion effects in the short term, but it cannot be used in the body for a long time, and it is easy to cause turbidity and cause secondary cataracts. And it is easy to cause inflammation and bacterial infection after implantation in the body; or use the loop to load anti-inflammatory drugs, but it cannot achieve a long-term application effect

Method used

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  • Surface-modified artificial lens with coating layer carrying drug and preparation method thereof
  • Surface-modified artificial lens with coating layer carrying drug and preparation method thereof
  • Surface-modified artificial lens with coating layer carrying drug and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Dissolve 1.1093g of PEG with NHS end groups (molecular weight: 1109.3g / mol, purchased from Polypure AS, Norway) in 1L of deionized water to obtain a 1mmol / L PEG-NHS solution; dissolve 1.21g of Tris in 0.5 In L deionized water, calibrate to pH 7.5 with 0.1mol / L HCL, add deionized water to 1L; weigh 8.775g NaCl and 0.5g R-hirudin into the prepared Tris-HCl buffer to obtain 0.5g / L L of R-hirudin solution; put the IOL (intraocular lens) into the PEG-NHS solution and soak for 2h, then put it into the vacuum plasma equipment, evacuate (about 0.5h) to a pressure of 10Pa, and pass it into the argon adjustment chamber Body pressure to 18Pa, then turn on the high-frequency power supply after maintaining the pressure for 5 minutes, adjust the power to 60W, and dry it in vacuum at 37°C after discharging for 5 minutes; soak the IOL modified by PEG-NHS in the prepared R-hirudin solution for 3 hours Rinse three times with Tris-HCl buffer solution and deionized water respectively, and ...

Embodiment 2

[0039] Dissolve 2.2186g of PEG with NHS end groups (molecular weight: 1109.3g / mol) in 1L of deionized water to obtain a 2mmol / L PEG-NHS solution; dissolve 1.21g of Tris in 0.5L of deionized water and use 0.1mol / L HCL calibrated to pH7.5, add deionized water to 1L; weigh 8.775gNaCl and 1g R-hirudin into the prepared Tris-HCl buffer to obtain 1g / L R-hirudin solution; put IOL into Soak in the PEG-NHS solution for 3 hours, then put it into the vacuum plasma equipment, evacuate (about 0.5 hours) to a pressure of 10Pa, introduce argon gas to adjust the pressure of the cavity to 18Pa, and turn on the high-frequency power after holding the pressure for 5 minutes. Regulate 80W, discharge for 5min and then dry under vacuum at 37°C; soak the PEG-NHS modified IOL in the prepared R-hirudin solution, rinse with Tris-HCl buffer and deionized water for 3 times after soaking for 3h, 37 The IOL with PEG sustained-release hirudin drug coating was prepared after vacuum drying at ℃ for 24 h.

Embodiment 3

[0041] Dissolve 1.6093g of PEG with NHS end groups (molecular weight: 1609.3g / mol) in 1L of deionized water to obtain a 1mmol / L PEG-NHS solution; dissolve 1.21g of Tris in 0.5L of deionized water and use 0.1mol / L HCL was calibrated to pH7.5, and deionized water was added to 1L; 8.775gNaCl and 0.5g R-hirudin were weighed and added to the prepared Tris-HCl buffer solution to obtain a 0.5g / L R-hirudin solution; Soak in PEG-NHS solution for 3 hours, then put it into vacuum plasma equipment, evacuate to a pressure of 10Pa, introduce argon gas to adjust the pressure of the chamber to 18Pa, keep the pressure for 5min, turn on the high-frequency power supply, and adjust the power to 60W , after discharge for 5 minutes, vacuum drying at 37°C; immerse the PEG-NHS modified IOL in the prepared R-hirudin solution, rinse with buffer solution and deionized water for 3 times after soaking for 3 hours, and dry in vacuum at 37°C for 24 hours Afterwards, the IOL with PEG sustained-release hirud...

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Abstract

The invention discloses a surface-modified artificial lens with a coating layer carrying a drug, and a preparation method thereof. An implementation method of the surface-modified artificial lens with a coating layer carrying a drug comprises the following steps of 1, dissolving PEG with NHS end groups in deionized water to obtain a PEG-NHS solution, 2, adding an artificial lens into the PEG-NHS solution for immersion, 3, putting the immersed artificial lens into a plasma device, feeding argon into the plasma device, and carrying out plasma treatment to obtain a modified artificial lens, and 4, immersing the modified artificial lens in a recombinant hirudn solution, carrying out flushing, and carrying out vacuum drying to obtain the surface-modified artificial lens grafted by hirudn and having self-cleaning effects. The surface-modified artificial lens grafted by hirudn has light transmittance of 96%, good mechanical properties, and a certain effect of resisting inflammation, bacteria and adhesion of aqueous fluid proteins, and can effectively resist cell differentiation proliferation and soterocyte adhesion. The preparation method has simple processes and can be industrialized easily.

Description

technical field [0001] The invention relates to a method for surface modification of biomedical materials. The method is based on polyethylene glycol superhydrophilic coating, using polyethylene glycol end group grafting or polyethylene glycol chain length embedding as a drug carrier, and recombinant hirudin as a loaded drug. The artificial lens has physical hydrophilicity and has the performance of slow-release hirudin medicine. Background technique [0002] Cataract is currently the leading cause of blindness in my country. The preferred surgical method for the treatment of cataract at home and abroad is cataract extraction combined with intraocular lens (IOL) implantation. As a biological material, IOL implantation in the eye will cause a series of reactions related to biocompatibility, such as postoperative inflammatory response, posterior capsule opacification (PCO), anterior capsule opacification (anterior capsule opacification, ACO), etc., these surgical complicatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54A61F2/16
Inventor 王迎军任力焦艳郑志雯
Owner SOUTH CHINA UNIV OF TECH
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