Method for producing neomycin sulfate

Abstract

The invention discloses a method for producing neomycin sulfage. The method comprises the steps that a spore suspension liquid is prepared by inoculating and culturing spores, then the spore suspension liquid is subjected to fermentation, absorption, desorption, concentration and refining, and the neomycin sulfate is formed. When a basal culture medium is prepared and fermented, starch is utilized to replace rice flour in the traditional processing in the proportion of 5%; and by means of the measure, the material loss can be reduced, the labor intensity is reduced, the work environment can be improved, and the production can be powerfully guaranteed.

Description

technical field

[0001] The invention belongs to the field of biopharmaceuticals and relates to a production method of neomycin sulfate. Background technique

[0002] In the production process of neomycin sulfate, a large amount of grain processing raw materials are used in the fermentation process, among which, rice flour obtained by crushing and sieving broken rice accounts for the largest proportion in the fermentation medium. Due to the unstable source of broken rice raw materials, the processing technology is relatively simple compared with other raw materials. During the processing process, the labor intensity of the operators is high, the noise is large, there is a lot of dust, and the working environment is harsh. At the same time, the particle size of rice flour after processing broken rice is relatively coarse, which reduces the degree of absorption and utilization of rice flour by microorganisms on the one hand; on the other hand, too much remaining dry matter brin...