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The use of total flavonoids of seabuckthorn

A technology of seabuckthorn total flavonoids and their uses, which is applied in the field of preparing drugs for treating diabetic retinopathy, and achieves the effects of high safety, small toxic and side effects, and remarkable curative effect

Active Publication Date: 2014-10-15
樟树市永安科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant literature report on the use of total flavonoids of seabuckthorn for eye diseases

Method used

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  • The use of total flavonoids of seabuckthorn
  • The use of total flavonoids of seabuckthorn
  • The use of total flavonoids of seabuckthorn

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The preparation of embodiment 1 seabuckthorn total flavonoids of the present invention

[0030] The preparation process of seabuckthorn total flavonoids: take seabuckthorn medicinal materials, add 10 times the amount of water to decoct 3 times, each time for 2 hours, combine the extracts, concentrate under reduced pressure to an appropriate amount, and remove the precipitate; the concentrated solution is separated by macroporous resin, and firstly use 4 times The column volume was eluted with water, and then eluted with 4 times column volume of 60% ethanol. The ethanol eluate was collected, concentrated under reduced pressure, and finally dried under reduced pressure to obtain the total flavonoid extract of seabuckthorn, with a total flavonoid content of more than 50%.

Embodiment 2

[0031] The preparation of embodiment 2 pharmaceutical tablet of the present invention

[0032] Preparation of seabuckthorn total flavonoids tablets: tablets with different contents of seabuckthorn total flavonoids were prepared respectively according to the conventional tablet preparation method, and the tablets used total seabuckthorn flavonoids as the main active ingredient. Auxiliary materials such as diluents, binders, disintegrants and lubricants are added during the preparation process.

[0033] The above diluent refers to at least one of starch, dextrin, lactose, powdered sugar, or at least one of their mixtures; the above binder refers to water, ethanol, starch slurry, hydroxypropyl methylcellulose At least one of the factors, or at least one of their mixtures; the above-mentioned disintegrating agent refers to at least one of sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, or at least one of their mixtures The lubricant refers to at least one of...

Embodiment 3

[0036] The preparation of embodiment 3 medicine eye drops of the present invention

[0037] Preparation of seabuckthorn total flavonoids eye drops: according to the conventional method for preparing eye drops, different concentrations of seabuckthorn total flavonoids eye drops were prepared respectively. The eye drops use total seabuckthorn flavonoids as the main active ingredient. In the preparation process, in addition to conventionally adding co-solvents, osmotic pressure regulators, antioxidants, preservatives, and pH regulators, auxiliary materials such as borneol, peppermint, and sodium hyaluronate or methylcellulose or Viscous excipients such as hydroxypropylmethylcellulose. Its purpose is to increase the concentration of the drug in the eye tissue, increase its bioavailability, enhance the curative effect and reduce adverse reactions.

[0038]The above co-solvent refers to: at least one selected from cyclodextrin, polypropylene polymer, polyvinyl alcohol, polyvinylpyr...

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PUM

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Abstract

The invention provides application of total flavones of hippophae rhamnoides in preparation of treating diabetic retinopathy. The invention also provides a medicine composition for treating the diabetic retinopathy. The medicinal flavonoid compound can be used for resisting the oxidative damage of hydrogen peroxide, improving the activity of cells as well as the oxidation reduction function, and bringing protection to the retinal pigment epithelium (RPE), so that photoreceptor cells can be protected, the macular oedema is reduced, the vision is improved, and the total flavones of hippophae rhamnoides are expected to be developed into a new medicine for treating the diabetic retinopathy.

Description

technical field [0001] The invention relates to a new application of total flavonoids of seabuckthorn, in particular, an application in the preparation of medicines for treating diabetic retinopathy, which belongs to the field of medicines. Background technique [0002] Diabetic retinopathy (DR) is one of the most common and serious vascular complications of diabetes. It is the reaction of diabetic metabolic disorder and endocrine system and blood system damage on the retina, which can lead to irreversible blindness. Diabetic patients are more blind than non-diabetic patients. 25 times higher risk. There are two types of DR lesions: non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). NPDR manifests as venous dilatation and beading, microvascular tumors, intraretinal hemorrhages, hard exudates, abnormal microvascular, and cotton wool spots. NPDR continues to develop into PDR, which is characterized by neovascularization and gliosis. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048
Inventor 王达宾施俊辉
Owner 樟树市永安科技有限公司
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