Synthesis method of bis-(N-(7-hydroxy-8-methyl-5-phenylphenazine-3-subunit)dimethylammonium)sulfate
A technology of phenylphenazine and dimethylammonium is applied in the field of compound preparation and achieves the effects of high yield, low cost and high product purity
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Embodiment 1
[0014] Example 1: Add 108g of p-hydroxy-m-toluidine, 123g of N,N-dimethylaniline, 250g of hydrochloric acid, and 200g of water into a 1000ml three-neck flask, cool to about 15°C, stir, and pass air at a pressure of 0.01-0.02Mpa 5 hour, then add aniline 95g, 100g hydrochloric acid into the three-necked flask, ventilate the air for 5 hours, after ventilating, add 109g sodium carbonate, add saturated sodium chloride solution 200 ml, let stand and separate layers, the upper layer is viscous, and the lower layer is Water layer, separate to remove the water layer; add 200ml of ethanol to the viscous material in the upper layer, stir and let stand for half an hour, remove the upper layer, and add 50% H 2 SO 4 A total of 98g was vacuum dehydrated and dried to obtain 110g of the product. After detection by liquid chromatography, the content is 85%, and the yield is 53.7%.
Embodiment 2
[0015] Example 2: 108g of p-hydroxy-m-toluidine, 123g of N,N-dimethylaniline, 250g of hydrochloric acid, and 200g of water were added to a 1000ml three-neck flask, cooled to about 10°C, stirred, and 200g of sodium dichromate was added once, and reaction 4 Add 95g of aniline and 100g of hydrochloric acid into the reaction flask, ventilate the air for 5 hours, after ventilating, add 109g of sodium carbonate, add 200 ml of saturated sodium chloride solution, and let stand to separate layers; the upper layer is viscous, and the lower layer is Water layer, separate to remove the water layer; add 200ml of ethanol to the viscous material in the upper layer, stir and let stand for half an hour, remove the upper layer, and add 50% H 2 SO 4 A total of 98g was vacuum dehydrated and dried to obtain 122g of the product. Detected by liquid chromatography, the content is 66%, and the yield is 41%.
Embodiment 3
[0016] Example 3: Add 108g of p-hydroxy-m-toluidine, 123g of N,N-dimethylaniline, 250g of hydrochloric acid, and 200g of water into a 1000ml three-neck flask, cool to about 10°C, stir, and pass air at a pressure of 0.01-0.02Mpa 6 hour, then add aniline 95g, 100g hydrochloric acid into the reaction flask, ventilate the air for 6 hours; Water layer, separate to the water layer. Add 200ml of acetone to the viscous material in the upper layer, stir and let it stand for half an hour, remove the upper layer, and add 50% H2O to the lower layer. 2 SO 4 A total of 98g was vacuum dehydrated and dried to obtain 140g of the product. Detected by liquid chromatography, the content was 86%, and the yield was 47%.
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