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Polyglutamic acid derivative as well as hydrogel and preparation method of polyglutamic acid derivative

A technology of polyglutamic acid and derivatives, which is applied in the fields of pharmaceutical formulations, medical preparations of non-active ingredients, and pharmaceutical sciences. It can solve the limitations of the application field, which has not been reported before, and the mechanical strength of the copolypeptide gel is low. and other problems, to achieve the effect of mature synthesis method, simple process and convenient operation

Inactive Publication Date: 2013-05-22
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the low mechanical strength of this copolypeptide gel has also greatly limited its application field, and it cannot be applied to the tissue engineering field that requires high mechanical strength of the material; and, currently, the side chain is an amide bond The preparation of polypeptide hydrogel materials has not been reported

Method used

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  • Polyglutamic acid derivative as well as hydrogel and preparation method of polyglutamic acid derivative
  • Polyglutamic acid derivative as well as hydrogel and preparation method of polyglutamic acid derivative
  • Polyglutamic acid derivative as well as hydrogel and preparation method of polyglutamic acid derivative

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Embodiment 1

[0031] The polyglutamic acid derivative of this embodiment is polyethylene glycol monomethyl ether-b-polyglutamic acid derivative modified by isopropylamine, specifically polyethylene glycol monomethyl ether-b-poly(N-isopropyl base-L-glutamine), which was prepared as follows:

[0032] (1) Preparation of polyethylene glycol monomethyl ether-b-polybenzyl L-glutamate (mPEG-b-PBLG) block copolymer

[0033] Under the protection of nitrogen, the amino-terminated polyethylene glycol monomethyl ether was dissolved in anhydrous N,N-dimethylformamide to initiate L-benzyl glutamate-N-carboxylate anhydride (BLG-NCA ) in a nitrogen environment at room temperature (15-25 ° C) closed ring-opening polymerization for 72 hours, the reaction solution was settled in excess anhydrous ether, and a white solid was obtained by suction filtration, and then vacuum-dried to constant weight; polyethylene glycol monomethyl Ether-b-polybenzyl glutamate block copolymer.

[0034] Among them, benzyl L-gluta...

Embodiment 2

[0045] Preparation of polyethylene glycol monomethyl ether-b-poly(N-isopropyl-L-glutamine) hydrogel:

[0046] (1) Configuration of pH=7.4 phosphate buffer solution

[0047] Accurately weigh 9.078g of potassium dihydrogen phosphate and 23.876g of disodium hydrogen phosphate, dissolve them in 1000mL of double distilled water and stir evenly, then take 800mL of disodium hydrogen phosphate solution and 200mL of potassium dihydrogen phosphate solution in a 1000mL volumetric flask Constant volume was obtained to obtain a phosphate buffer solution with pH=7.4.

[0048] (2) Preparation of polyethylene glycol monomethyl ether-b-poly(N-isopropyl-L-glutamine) hydrogel

[0049] Dissolve polyethylene glycol monomethyl ether-b-poly(N-isopropyl-L-glutamine) in phosphate buffer solution with pH=7.4 to make a viscous solution and put it in a constant temperature shaking box at 37°C After 2 hours, the hydrogel of the polymer was formed; the formation of the hydrogel was macroscopically charac...

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Abstract

The invention discloses a polyglutamic acid derivative as well as a hydrogel and a preparation method of the polyglutamic acid derivative. The structure formula of the polyglutamic acid derivative is shown in a formula (I), wherein n is any integer of 20-60. During the preparation, isopropamide is successfully introduced into a methoxy polyethylene glycol-b-polyglutamic acid block copolymer through a simple chemical modification method and a biodegradable hydrogel material with a certain mechanical strength is successfully prepared. The mechanical property of the hydrogel material can be changed by controllably changing the length of the polymer chain segment, so that the polyglutamic acid derivative and the hydrogel disclosed by the invention can be widely applied to the fields of medicine carriers, tissue engineering scaffolds and the like.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a polyglutamic acid derivative, its hydrogel and a preparation method. Background technique [0002] Biomedical materials are new polymer materials used to diagnose, treat, repair or replace damaged tissues and organs of living organisms or enhance their functions. It is the basis for the study of artificial organs, medical devices and pharmaceutical preparations, and has become an important branch of materials science. Biomedical polymer materials, as a sub-discipline of polymer materials, began to be researched and understood with the rapid development of biotechnology in the past 40 years. In addition to natural medical polymer materials, synthetic biomedical polymer materials have emerged with the continuous advancement of polymer synthesis technology. [0003] Polypeptide material, as a kind of polymer material whose main chain is connected by peptide bonds, is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C08G69/40C08J3/075A61K47/34A61L27/18A61L27/52
Inventor 郎美东肖艳卜宇
Owner EAST CHINA UNIV OF SCI & TECH
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