Cefpirome sulfate pharmaceutical composition powder injection

Abstract

The invention provides a cefpirome sulfate pharmaceutical composition powder injection, relating to the field of a pharmaceutical preparation and a preparation method thereof. The invention solves the problems of high dosage of single cefpirome sulfate and metronidazole preparation, poor treatment effect after combination, and great side effect at present. The main materials of the pharmaceutical composition are cefpirome sulfate and metronidazole lipid microspheres, the auxiliary material is sodium carbonate, the weight ratio of the cefpirome sulfate (on the basis of cefpirome) to the metronidazole lipid microspheres (on the basis of metronidazole) is 100:6-100:20, and the weight ratio of the cefpirome sulfate (on the basis of cefpirome) to the sodium carbonate is 1000:242; and after the pharmaceutical composition is prepared into the powder injection, the pH value of the water solution of the pharmaceutical composition is 5.5-7.0. The pharmaceutical composition powder injection provided by the invention has high curative effect, and can reduce the consumption of the metronidazole by more than 80%, thereby greatly relieving or avoiding the toxic and side effects of the metronidazole, especially digestive tract reactions, including nausea, vomit, inappetence, abdominal colic and neurotoxicity, and lowering the incidence rate of adverse reactions.

Description

Technical field: [0001] The invention relates to the field of pharmaceutical preparations and preparation methods, in particular to a cefpirome sulfate pharmaceutical composition powder for injection and a preparation method thereof. Background technique: [0002] Cefpirome (Cefpirome) is an ultra-broad-spectrum 4th generation cephalosporin for injection jointly developed by French Roselle Euclaf Company and German Hoechst Company. This product has a wide antibacterial spectrum and is very stable to a variety of β-lactamases; and because of the positive and negative ions in its structure, the hydrophilicity is increased and it can penetrate the Gram-negative bacilli more quickly The outer membrane, which has a higher affinity for penicillin-binding proteins. Cefpirome distributes well in tissues, and its concentration can greatly exceed the MIC value of the main pathogenic bacteria. It is active against most Gram-negative and Gram-positive bacteria, and is more suitable for...

AI Technical Summary

Problems solved by technology

[0007] Infections in clinical operations are often accompanied by mixed infections containing anaerobic bacteria and aerobic bacteria, rather than a single anaerobic or aerobic bacterial infection, because metronidazole is the clinical first choice for the treatment of anaerobic infection, Clinically, cefpirome sulfate and metronidazole are commonly used in combination to prevent surgical infection and treat complex infections containing anaerobic bacteria. When the dosage of metronidazole is very large, the toxic and side effects of metronidazole are very strong. Normal therapeutic doses of metronidazole can cause gastrointestinal reactions, the most common of which include nausea, vomiting, loss of appetite, abdominal cramps and high nervousness. toxicity

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