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A technology of cefpirome sulfate and injection powder, which is applied in the field of pharmaceutical preparations and preparations, can solve the problems of strong toxic and side effects of metronidazole, large dosage of metronidazole, etc., and achieve the effect of simple preparation process and guaranteed stability
Inactive Publication Date: 2013-06-05
HAINAN WEI KANG PHARMA QIANSHAN
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[0007] Infections in clinical operations are often accompanied by mixed infections containing anaerobic bacteria and aerobic bacteria, rather than a single anaerobic or aerobic bacterial infection, because metronidazole is the clinical first choice for the treatment of anaerobic infection, Clinically, cefpirome sulfate and metronidazole are commonly used in combination to prevent s
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Embodiment 1
[0031] Embodiment one, cefpirome sulfate composition powder for injection, in 1000
[0034] Metronidazole lipid microspheres (calculated as metronidazole) 50g
[0035] Sodium carbonate 121g
[0036] Preparation Process:
[0037] Put the prescribed amount of cefpirome sulfate, metronidazole lipid microspheres and sodium carbonate into the V-type high-efficiency asymmetric mixer, mix for 1.5 hours, make a mixed powder injection, put the mixed powder injection into the sterilized Aluminum cans; capping, labeling, and packaging the aluminum cans; adding the mixed powder injection into the filling machine, adjusting the filling volume according to the batch production instructions, filling them into vials, buckling the butyl rubber stoppers, capping, After lamp inspection and packaging, the cefpirome sulfate pharmaceutical composition powder for injection can be obtained.
Embodiment 2
[0038] Embodiment two, cefpirome sulfate composition powder injection for injection, in 1000
[0041] Metronidazole lipid microspheres (calculated as metronidazole) 100g
[0042] Sodium carbonate 121g
[0043] Preparation Process:
[0044] Put the prescribed amount of cefpirome sulfate, metronidazole lipid microspheres and sodium carbonate into the V-type high-efficiency asymmetric mixer, mix for 1.5 hours, make a mixed powder injection, put the mixed powder injection into the sterilized Aluminum cans; capping, labeling, and packaging the aluminum cans; adding the mixed powder injection into the filling machine, adjusting the filling volume according to the batch production instructions, filling them into vials, buckling the butyl rubber stoppers, capping, After lamp inspection and packaging, the cefpirome sulfate pharmaceutical composition powder for injection can be obtained.
[0045] c...
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Abstract
The invention provides a cefpirome sulfate pharmaceutical composition powder injection, relating to the field of a pharmaceutical preparation and a preparation method thereof. The invention solves the problems of high dosage of single cefpirome sulfate and metronidazole preparation, poor treatment effect after combination, and great side effect at present. The main materials of the pharmaceutical composition are cefpirome sulfate and metronidazole lipid microspheres, the auxiliary material is sodium carbonate, the weight ratio of the cefpirome sulfate (on the basis of cefpirome) to the metronidazole lipid microspheres (on the basis of metronidazole) is 100:6-100:20, and the weight ratio of the cefpirome sulfate (on the basis of cefpirome) to the sodium carbonate is 1000:242; and after the pharmaceutical composition is prepared into the powder injection, the pH value of the water solution of the pharmaceutical composition is 5.5-7.0. The pharmaceutical composition powder injection provided by the invention has high curative effect, and can reduce the consumption of the metronidazole by more than 80%, thereby greatly relieving or avoiding the toxic and side effects of the metronidazole, especially digestive tract reactions, including nausea, vomit, inappetence, abdominal colic and neurotoxicity, and lowering the incidence rate of adverse reactions.
Description
Technical field: [0001] The invention relates to the field of pharmaceutical preparations and preparation methods, in particular to a cefpirome sulfate pharmaceutical composition powder for injection and a preparation method thereof. Background technique: [0002] Cefpirome (Cefpirome) is an ultra-broad-spectrum 4th generation cephalosporin for injection jointly developed by French Roselle Euclaf Company and German Hoechst Company. This product has a wide antibacterial spectrum and is very stable to a variety of β-lactamases; and because of the positive and negative ions in its structure, the hydrophilicity is increased and it can penetrate the Gram-negative bacilli more quickly The outer membrane, which has a higher affinity for penicillin-binding proteins. Cefpirome distributes well in tissues, and its concentration can greatly exceed the MIC value of the main pathogenic bacteria. It is active against most Gram-negative and Gram-positive bacteria, and is more suitable for...
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Application Information
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