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Moisture-proof coating method used for traditional Chinese medicine salvia miltiorrhiza extract powder or particles

A technology of extract powder and traditional Chinese medicine, which is used in pharmaceutical formulations, powder delivery, medical preparations containing active ingredients, etc., to achieve high stability, avoid contact, and good moisture-proof effects.

Inactive Publication Date: 2013-06-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past ten years, researchers have gradually carried out some research on hot melt coating technology, but there is no application of this technology in the pharmaceutical industry, and the discussion and research on this aspect

Method used

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  • Moisture-proof coating method used for traditional Chinese medicine salvia miltiorrhiza extract powder or particles
  • Moisture-proof coating method used for traditional Chinese medicine salvia miltiorrhiza extract powder or particles
  • Moisture-proof coating method used for traditional Chinese medicine salvia miltiorrhiza extract powder or particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Salvia miltiorrhiza dry extract powder 500g, 6% starch slurry 10g, glyceryl palmitostearate (PrecirolATO5) 50g

[0019] (1) Processing of Danshen dry extract powder before coating: take 2000g of Danshen decoction slices, add four times the amount of water to extract and decoct four times, decoct for 1.5h each time, filter, combine the decoctions, and concentrate to a relative Density is 1.30 (90 ℃) clear ointment, dry under reduced pressure, pulverize, pass through 60 mesh sieves to obtain 1600g of traditional Chinese medicine salvia miltiorrhiza root extract powder, set aside;

[0020] (2) Place 500 g of the dry powder of Danshen extract prepared in step 1 in a Glatt top-spray fluidized bed coating machine to control the atomization pressure to 1.5 Pa, the inlet air temperature to 50-55°C, and the material temperature to 45-47°C. ℃, granulate 10g of starch slurry with 6% (injected at a rate of 10.8g / min), and stop granulating after forming free small particles; install...

Embodiment 2

[0025] Salvia miltiorrhiza dry extract powder 500g, 6% starch slurry starch 10g, COMPARITOL888ATO 50g

[0026] The salvia salviae extract dry powder 500g that embodiment 1 step (1) makes is placed in the fluidized bed coating machine of Glatt top spray type, and the control atomization pressure is 1.5 Pa, and inlet air temperature is 50-55 ℃, and material temperature is At 45-47°C, granulate with 10g of 6% starch slurry (injected at a rate of 10.8g / min), and stop granulating after forming free small particles; install a double-layer nozzle system as a spray gun device, set The air inlet temperature is 48-55°C, the temperature of the coating material reaches 68-73°C, and the coating is applied at a spray rate of 6.5g / min. When the coating liquid is sprayed, stop heating and blow 30°C cold air to 33 ℃, take out, that is.

[0027] The results of hygroscopicity study showed that the equilibrium moisture absorption rate of the coated Danshen extract powder was 80.28% of that of th...

Embodiment 3

[0031] Danshen Granules 100g Glycerin Palmitostearate (PrecirolATO5) 5g

[0032] (1) Processing of traditional Chinese medicine Danshen dry extract powder before coating: take 1000g of Danshen decoction pieces, add 90% ethanol (6000ml) to reflux for 1.5h, filter, recover ethanol from the filtrate to a thick paste (relative density is 1.20-1.25); The dregs were decocted with water for 1 hour, filtered, the filtrate was combined with the above thick paste, concentrated under reduced pressure (concentrated by rotary evaporation at 80°C) and dried (vacuum dried at 80°C) to obtain 540 g of extract powder, crushed, and passed through 60 mesh screen. Take 250g of the prepared extract powder, select dextrin in a ratio of 1:1, use dilute ethanol as a wetting agent to make granules, pass through a 14-mesh sieve, dry at 50°C, pass through a 10-mesh sieve, and granulate to obtain Salvia granules 450g.

[0033] Put 100g of Salvia miltiorrhiza granules in a top-spray fluidized bed coating...

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Abstract

The invention provides a moisture-proof coating method used for traditional Chinese medicine salvia miltiorrhiza extract powder or particles. According to the moisture-proof coating method used for the traditional Chinese medicine salvia miltiorrhiza extract powder or the particles, the traditional Chinese medicine salvia miltiorrhiza extract powder is placed in a top-spraying type fluid-bed coating machine and is prepared into dissociative small particles by means of 6% starch slurry; pulverization pressure is controlled to be 1.5 Pa; temperature of inlet wind is controlled to be at 50-55 DEG C; temperature of materials is controlled at 45-47 DEG C; after the traditional Chinese medicine salvia miltiorrhiza extract powder is prepared into dissociative the small particles by means of the 6% starch slurry and a spraying nozzle system capable of containing two layer of the small particles is installed to serve as a spraying gun device, coating materials (glycerol palmitic acid stearate or behenic acid glyceride) are heated to 55-78 DEG C; after hot air at the temperature of 55-60 DEG C is infused and the materials to be coated are fused, the temperature of the hot air and the materials reach to 66-78 DEG C; and then coating liquid is sprayed; after the coating liquid is sprayed, heating is stopped, and the materials to be coated are taken out when cooled to the temperature of 30-35 DEG C through blowing cold wind at the temperature of 30 DEG C. Products obtained with the method are good in moisture-proof effect, simple in process, small in coating amount, and high in industrial application value.

Description

technical field [0001] The invention relates to traditional Chinese medicines, in particular to a preparation method of the traditional Chinese medicine salvia miltiorrhiza, in particular to a moisture-proof coating method for the traditional Chinese medicine salvia miltiorrhiza extract powder or granules. Background technique [0002] Most modern Chinese medicine preparations are made after extraction and separation from Chinese herbal medicines. Because it contains sugar, starch, resin, gum, mucus, tannin and other ingredients, it is easy to absorb moisture; and some active ingredients in traditional Chinese medicine, such as saponins and cardiac glycosides, also have strong moisture absorption. Therefore, the extract obtained from the traditional Chinese medicine compound has complex components, high impurity content, and strong moisture absorption. After absorbing moisture, traditional Chinese medicine preparations become soft, darker in appearance, agglomerated, fluidi...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/14A61K9/16
Inventor 魏莉张娜姜文雅
Owner SHANGHAI UNIV OF T C M
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