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Application of swallow cimitin in preparation of whitening and freckle removing product

A technology of whitening and removing freckles, avenin, which is applied in the field of application of avenin in the preparation of whitening and removing freckles products, which can solve the problems of easy oxidation and instability, and achieve the effects of inhibiting synthesis, good inhibitory effect, and remarkable freckle removing effect

Inactive Publication Date: 2013-06-05
杨艳姣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although vitamin C can be used orally or externally, it is quite unstable and easily oxidized

Method used

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  • Application of swallow cimitin in preparation of whitening and freckle removing product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Avenin can be obtained by the following method: Weigh 20 parts of black quinoa, 15 parts of oatmeal leaves, 10 parts of noni fruit and 20 parts of lupine, soak in methanol at room temperature for about 10 hours, after soaking and extraction, After filtration and concentration under reduced pressure, avenin is obtained.

Embodiment 2

[0034] Test method: Mushroom tyrosinase (Sigma, E.C.1.14.18.1) was used to study the inhibitory activity of avenin prepared in Example 1. Dissolve tyrosinase in 1 / 15M phosphate buffer (pH 6.8) so that the concentration of the enzyme solution is 368U / ml. As a substrate, L-3,4-dihydroxyphenylalanine (L-DOPA) was dissolved in 1 / 15M phosphate buffer (pH 6.8) so that the concentration of L-DOPA was 5 mM / ml. The avenin prepared in Example 1 was prepared into 4 concentrations of 50, 100, 200 and 400 uM with distilled water. All the above solutions are ready-to-use.

[0035] At 25°C, add 0.8ml of 5mM levodopa (L-DOPA), 1.2ml of 1 / 15M PBS (PH6.8) and 0.1ml of the test substance to the test tube successively, add an equal amount of distilled water to the negative control group, Incubate at 37°C for 5 min, then add 0.3 ml of mushroom tyrosinase at 368 U / ml, adjust the wavelength of the ultraviolet spectrophotometer to A475, measure the light absorption value after 0.5 min and 2 min of ...

Embodiment 3

[0045] Activity experiment:

[0046] Observation objects: young and middle-aged women aged 20-45. Choose 100 examples of middle-aged women with pigments such as chloasma, butterfly spots, and age spots on the face in various degrees.

[0047] Observation method: Make a lotion containing 5% avenin, and apply the lotion after cleaning the skin every night before going to bed. Continuous use for 28 days is a course of treatment.

[0048] Efficacy criteria: ①Cure: chloasma basically disappears; ②marked effect: chloasma subsides by more than 50%; ③effective: chloasma subsides by more than 10% or the color of the patches fades; ④ineffective: no change before and after treatment.

[0049]The treatment effect is shown in Table 2. The results show that the product prepared by adopting avenalin has remarkable freckle-removing effect.

[0050] Table 2

[0051]

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PUM

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Abstract

The invention discloses application of swallow cimitin in preparation of a whitening and freckle removing product. Through a large amount of experiences, the swallow cimitin is found to have a good restraining function for tyrosinase and can restrain synthesis of melanin of skin. The product prepared by the adoption of the swallow cimitin is good in freckle removing effect and wide in application prospect.

Description

technical field [0001] The invention belongs to the application of abaculin, and more specifically relates to the application of abavaridin in the preparation of whitening and freckle-removing products. Background technique [0002] Since 1980, the melanin production pathway has been studied by dermatology researchers. Melanin is a high molecular biopigment, and the starting material for the production of melanin in skin cells is tyrosine. Tyrosinase in melanoblasts reacts with tyrosine in the blood to produce a substance called "dopa", which is then converted into melanin. Therefore, by inhibiting the activity of tyrosinase, the synthesis of melanin can be effectively inhibited, so as to achieve the purpose of whitening and removing spots. [0003] At present, there are many methods to remove abnormal pigment spots, such as pigment lightening agent or whitening and spot lightening agent, such as hydroquinone, kojic acid, arbutin, vitamin C and related pigment lightening ag...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K8/97A61Q19/00A61Q19/04A61P17/00
Inventor 杨艳姣
Owner 杨艳姣
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