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Determination method of fingerprints of drugs

A technology of fingerprints and determination methods, which is applied in the field of quality standard determination, and can solve problems such as difficulty in monitoring the quality of Yiqing preparations

Active Publication Date: 2014-12-24
CHENGDU KANGHONG PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0007] Aiming at the problem that the quality of Yiqing preparations is difficult to monitor due to the different sources and origins of the extracts of Scutellaria baicalensis, rhubarb and Coptis chinensis currently on the market, the present invention obtains a medicine that can effectively monitor the quality of medicines through a large number of experimental studies. Thereby ensuring the safe and effective fingerprint detection method of drugs

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Embodiment Construction

[0143] 1. Samples and Reagents

[0144] 1.1 Sample Yiqing Capsules, Rhubarb Extract, Coptis Rhizoma Extract, and Scutellaria Baicalensis Extract were provided by Chengdu Kanghong Pharmaceutical Co., Ltd.

[0145] Prepare according to the following process:

[0146] The preparation process of Yiqing Capsules: Coptidis 660g, Rhubarb 2000g, and Scutellaria baicalensis 1000g; the preparation method is: the above three herbs are decocted twice with water, the first time is 1.5 hours, the second time is 1 hour, the decoctions are combined, filtered, The filtrates were respectively concentrated under reduced pressure and spray-dried to obtain the extract powder of Scutellaria baicalensis and the mixed extract powder of rhubarb and coptis. The two kinds of extract powders are granulated separately, dried and crushed, and appropriate amount of starch, talcum powder and magnesium stearate are added, mixed evenly, packed into capsules, made into 1000 granules, and ready to be obtained. ...

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Abstract

The invention relates to a determination method of fingerprints of drugs, concretely to the determination method of the fingerprints of rheum officinale extract, coptis extract, baical skullcap root extract and a medicinal preparation composed of the above three drugs. Preparation of tested solution comprises: taking traditional Chinese medicine extracts for precise weighing, putting in a volumetric flask, adding ethanol to dissolve, diluting to a constant volume, and filtering to obtain the tested solution. A chromatographic condition is that octadecylsilane bonded silica gel is used as a filling material, a gradient elution is used, a mobile phase A is acetonitrile, a mobile phase B is 0.1 % formic acid and 20 mM aqueous ammonium acetate, and a detection wavelength is 254 nm. A determination comprises precisely absorbing the tested solution into a liquid chromatography, and determining with an HPLC method to obtain the fingerprints. The determination method of the fingerprints is high in repeatability and comprehensive in substance detection, can be directly used with a mass spectrometer, and is good in drug monitoring efficiency.

Description

technical field [0001] The invention relates to a quality standard determination method, in particular to a fingerprint of a medicine and a determination method thereof. Background technique [0002] Yiqing Capsule is developed from "Xiexin Decoction" in the famous medical book "Synopsis of the Golden Chamber" in Han Dynasty. , forcing blood to flow indiscriminately, vomiting blood, epistaxis, constipation and redness; accumulation of heat in the three energizers, red and swollen eyes, sores on the mouth and tongue, external syndrome sores, heart and chest distress, constipation; damp-heat jaundice, irritability and fullness in the chest, yellow tongue coating Greasy, pulse number real person. Yiqing Capsules and Granules are developed according to the Han Dynasty prescription, and the functions and indications of Yiqing Capsules are: clearing heat, purging fire, detoxifying, removing blood stasis, cooling blood and stopping bleeding. It is used for body heat and irritabil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
Inventor 邬智刚朱小兰柯潇
Owner CHENGDU KANGHONG PHARMA CO LTD
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