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Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof

A three-dimensional porous, inorganic composite technology, applied in medical science, surgery, etc., can solve the problems of drug release regulation that is difficult to control, lack of highly penetrating channels, organic/inorganic composite scaffolds, etc.

Active Publication Date: 2014-11-26
广州雄俊智能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of bioceramic stents (such as hydroxyapatite (HA), β-tricalcium phosphate (β-TCP)) for local drug sustained release is that because such stents generally adopt the traditional impregnation method to load drugs on On the stent, it is difficult to control the drug release pattern
[0007] In summary, there is a lack of research in the field on organic / inorganic composite scaffolds with highly ordered porous structures, highly permeable channels, and capable of local drug delivery to bone repair sites for a long time

Method used

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  • Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof
  • Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof
  • Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof

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preparation example Construction

[0070] The invention relates to an organic / inorganic composite three-dimensional porous stent with drug slow-release effect and a preparation method thereof. With the help of MAM (Motor Assisted Microsyringe) free forming technology, under the control of the computer, the inorganic / organic / drug composite material with certain fluidity in the extrusion cavity is extruded layer by layer through the nozzle On the stage, a three-dimensional porous scaffold is formed. The preparation process of the present invention is simple and easy to implement, low cost, high efficiency, no need for post-processing of the stent, computer control, the prepared three-dimensional porous composite stent containing drugs is suitable for drug loading and sustained release, and has advantages in the field of bone tissue engineering Broad application prospects.

[0071] In the present invention, the term "comprising" or "including" means that various ingredients can be used together in the mixture or com...

Embodiment approach

[0154] The purpose of the present invention is to propose a novel organic / inorganic composite three-dimensional porous scaffold with a slow drug release effect and a fat-soluble polymer as the organic phase based on the MAM free forming technology and a preparation method thereof. A method of gradient volatilization solvent is proposed to completely remove the organic solvent used in the material compounding process, which can effectively avoid the settlement and agglomeration of inorganic powder that may occur during the solvent volatilization process, and lay the foundation for the subsequent formation of the scaffold . In addition, while ensuring the stent's requirements for pore size, porosity, and pore penetration, by changing the relative ratio between the components of the stent, the mechanical properties, degradability, drug release, and antibacterial properties of the stent can be controlled.

[0155] The method for preparing the organic / inorganic composite three-dimensi...

Embodiment 1

[0184] (1) Synthesis of β-Tricalcium Phosphate (β-TCP) Powder:

[0185] (a) Weigh 115.42g Ca(NO 3 ) 2 ·4H 2 O in a 2L beaker, add 967.74ml of deionized water, and adjust the pH to 8.2±0.1[Ca] with ammonia water;

[0186] (b) Weigh 43.03g (NH 4 ) 2 HPO 4 In a 3L beaker, add 645.16mL of deionized water, and adjust the pH to 8.2±0.1 with ammonia water [P];

[0187] (c) Place the Ca solution in a 250mL separatory funnel, slowly add dropwise to the P solution (it can be dropped directly with a dropper), and use ammonia to maintain the pH of the solution at 8.2±0.1;

[0188] (d) Stir the mixed solution for 24 hours, and then filter the precipitated deionized water three times with suction and wash with alcohol once;

[0189] (e) Dry at 100°C and remove water;

[0190] (f) Sintering at 850℃, holding for 2h, heating rate 4℃ / min.

[0191] The obtained powder is passed through a 200-mesh sieve for use.

[0192] (2) Preparation of polylactic acid / β-tricalcium phosphate / ibuprofen composite material (2...

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Abstract

The invention provides a preparation method of organic / inorganic composite three-dimensional porous scaffold with drug sustained release function. The method comprises the following steps of: (1) preparing organic / inorganic / drug composite material; and (2) putting the organic / inorganic / drug composite material obtained in the step (1) into an extrusion cavity of a motor assisted microsyringe (MAM) free-forming device to form the organic / inorganic composite three-dimensional porous scaffold with drug sustained release function.

Description

Technical field [0001] The invention relates to an organic / inorganic composite three-dimensional porous scaffold with drug slow release effect and a preparation method thereof, and belongs to the field of bone tissue engineering scaffolds and drug slow release. Background technique [0002] The development of suitable scaffold materials to treat bone defect diseases has always been a hot topic in bone tissue engineering research. As one of the key elements of bone tissue engineering, the ideal three-dimensional scaffold requires suitable pore size, high porosity and highly perforated pore structure to facilitate the exchange of oxygen, nutrients and metabolites, and to plant a large number of cells And proliferation, the secretion of extracellular matrix, and the ingrowth of blood vessels and nerves provide space and environment. [0003] When implanting bone tissue engineering scaffold materials into the defect site, the primary problem is to face the risk of inflammation and eve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/06A61L31/02
Inventor 宁聪琴袁萍
Owner 广州雄俊智能科技有限公司
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