Preparation method of medicinal polyvinylpyrrolidone with high molecular weight

A technology for polyvinylpyrrolidone and vinylpyrrolidone, which is applied in the fields of medicine, chemical industry and synthetic polymers, can solve the problems of difficulty in meeting pharmacopoeia requirements, difficulty in achieving uniform mixing, and increased energy consumption, and achieves omitting a wastewater treatment process, improving production efficiency, The effect of increased energy consumption
CN103254338AActive Publication Date: 2013-08-21HUZHOU SHENHUA HIGH POLYMER MATERIAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUZHOU SHENHUA HIGH POLYMER MATERIAL
Publication Date
2013-08-21

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Abstract

The invention discloses a preparation method of a medicinal polyvinylpyrrolidone with high molecular weight, which belongs to the fields of medicine chemical industry and synthetic polymer technology. The method concretely the following steps: putting water, N-vinyl pyrrolidone (NVP) and initiator into a reaction vessel in order, stirring and heating, generating a polymerization of NVP, after the reaction ends, filtering the polymer fluid, drying and crushing, and obtaining the finished product. The invention has the beneficial effect that, adsorption and ultrafiltration or the like are not needed for refining the polymer fluid, therefore the energy consumption of drying added for greatly dilution of the high viscosity polymer fluid which is used for improving refining efficiency and yield is avoided, simultaneously a lot of waste water generated in adsorption, ultrafiltration and other refining methods is avoided, thereby saving the waste water treatment process matched thereof. The invention employs continuous low temperature drying and crushing, thereby substantially improving production efficiency and protecting the product quality.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of polymer, relate in particular to the preparation method of the povidone of composite pharmaceutical specification, more specifically, the present invention relates to the preparation method of high molecular weight, high-purity povidone of composite American, European Pharmacopoeia standard, The invention belongs to the technical field of medicine chemical industry and synthetic polymer. Background technique

[0002] PVP is widely used in pharmaceutical production as a pharmaceutical excipient (Povidone, namely Povidone). The pharmacopoeias of various countries, especially the current pharmacopoeias of the United States, Europe, Japan, etc., have quality standards for povidone, especially for the impurities N-vinylpyrrolidone (hereinafter referred to as NVP), 2-pyrrolidone, formic acid, aldehydes, peroxides, There are strict requirements on the content of hydrazine, etc., and no other ad...

Claims

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