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External compound scorpion composition for treating age spots, chloasma, skin pigmentation and solar dermatitis, its preparation method and application

A technology for skin pigmentation and chloasma, which is used in medical preparations containing active ingredients, drug combinations, skin diseases, etc., and can solve problems such as easy recurrence, immune dysfunction of skin defense tissue, and residual pigmentation.

Active Publication Date: 2019-08-16
王秋红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calamine lotion, acetic acid solution, corticosteroids, and antihistamines are usually applied externally to relieve the symptoms, but after healing, desquamation or pigmentation of varying degrees is often left behind. The disease is prone to recurrent attacks, and there is no simple and easy method , Western medicine believes that immune desensitization therapy is the only method that can be fundamentally cured, but it is easy to cause immune dysfunction in skin defense tissues

Method used

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  • External compound scorpion composition for treating age spots, chloasma, skin pigmentation and solar dermatitis, its preparation method and application
  • External compound scorpion composition for treating age spots, chloasma, skin pigmentation and solar dermatitis, its preparation method and application
  • External compound scorpion composition for treating age spots, chloasma, skin pigmentation and solar dermatitis, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0014] Experimental example 1: Chemical research on the high temperature treatment of scorpion and centipede

[0015] Scorpion and centipede 1.72 kg of high-temperature treatment products with a weight ratio of 10:3 were extracted with 95% ethanol at 8 times the volume, heated and refluxed for 3 times, each time for 2 hours, filtered, and recovered under reduced pressure to obtain ethanol Extract 216g. Take 216g of the ethanol extract and carry out rough separation by silica gel column chromatography, and elute with petroleum ether-ethyl acetate solvent system. It was separated by modern separation techniques and methods such as gel column chromatography, and a total of 6 monomeric compounds were obtained. Through chemical analysis and comprehensive analysis of various spectral data, the chemical structures of six monomer compounds were determined, and the data were assigned. The separation process is shown in the table below.

[0016]

[0017] Compound 1 is a colorless n...

experiment example 2

[0024] Experimental example 2: GC-MS chemical composition analysis of scorpions, centipedes and their mixed medicinal materials after high temperature treatment

[0025] Scorpion, centipede and their mixed medicinal materials with a weight ratio of 10:5 are subjected to high temperature treatment according to the following method: take vaseline with a mass ratio of 1:1 to the medicinal material, heat and melt at 60-70°C, and mix scorpion, centipede and Mix medicinal materials, add molten vaseline and mix evenly, place in the heating room, gradually increase the temperature, the maximum temperature is 220°C, and keep the temperature at 190°C for no less than 30 minutes, and keep the time at 200-210°C for no less than 40 minutes , that is, high-temperature processed products of scorpion, centipede and mixed medicinal materials.

[0026] Accurately weigh 5g of the above-mentioned high-temperature treatment product, add 100mL of 95% ethanol, and extract under reflux for 3h, then c...

Embodiment 1

[0035] Embodiment 1: Combine the mixed extract of scorpion and centipede high temperature treatment with borneol and vaseline to make external ointment

[0036] (1) Make oil-in-water emulsion for external use

[0037] Take the original medicinal materials of scorpion, centipede and borneol with a weight ratio of 5:1:2, and prepare according to the following steps:

[0038] (1) High-temperature treatment of scorpions and centipedes: take the original medicinal materials of scorpions and centipedes, add vaseline with 3 times the weight of the composition of the two, heat and melt at 70°C, add the medicinal materials of scorpions and centipedes into molten vaseline and mix evenly , put it in an oven, gradually increase the temperature, the highest temperature is 220°C, among which the constant temperature is kept at 190°C for no less than 30 minutes, and the time at 200-210°C is not less than 40 minutes, take it out, let it cool, and you can get the scorpion, High-temperature tr...

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Abstract

The invention relates to an external use compound scorpion traditional Chinese medicine composition for treating senile plaque expelling, chloasma skin pigmentation and skin sunlight allergy (solar dermatitis), and the composition is composed of mixed high temperature processed medicinal materials of scorpion and centipede, and borneol and vaseline. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) high temperature treatment of scorpion and centipede: the scorpion and centipede medicinal material is added into melted vaseline for uniformly mixed, and is heated with gradual process, and the highest temperature is 200 DEG C., wherein, the 190 DEG C. constant temperature time is kept for not less than 30 minutes, and the 200-210 DEG C. time is kept for not less than 40 minutes, and the high temperature processed object (2) of scorpion and centipede medicinal material is obtained, and the alcohol extract product of scorpion and centipede high temperature processed medicinal material is prepared. (3) the mixed extract product, the borneol and the vaseline are proportioned by weight, and the compound scorpion composition is obtained. The compound scorpion composition is used for preparing various external use preparations, and can effectively treat senile plaque expelling, chloasma skin pigmentation and sunlight skin allergy (solar dermatitis).

Description

technical field [0001] The invention relates to a composition, in particular to an external compound scorpion traditional Chinese medicine composition for treating senile plaques, chloasma, skin pigmentation and skin sun allergy (solar dermatitis). Composed of mixed extracts of medicinal materials, borneol and vaseline, it can be used to remove age spots, chloasma, skin pigmentation and treat skin allergy to sunlight. Background technique [0002] Age spots, also known as "senile pigment spots", refer to a kind of lipofuscin pigment plaques that appear on the skin of the elderly. The main reason is that when the human body enters old age, various functions decline, metabolism in the body slows down, blood circulation tends to slow down, cell metabolism function also declines, excessive accumulation of free radicals in the body cannot be removed in time, and at this time the cells on the surface of the skin are susceptible to damage. The external environment, such as light, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/648A61P17/00A61K35/646A61K31/045
CPCY02A50/30
Inventor 匡海学王秋红
Owner 王秋红