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Hydroxyapatite/chitosan composite coating and preparation method thereof

A technology of hydroxyapatite and composite coatings, applied in coatings, medical science, prostheses, etc., can solve problems such as peeling, falling blocks, weak strength, etc., to improve bonding force, promote rapid formation, and good mechanical properties Effect

Inactive Publication Date: 2014-11-05
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the coating is prepared by electrochemical deposition technology, if the substrate is a non-conductive material, it needs to be modified. In addition, the obtained coating has the disadvantage of weak bonding strength with the substrate, and even peeling and falling off. Phenomenon

Method used

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  • Hydroxyapatite/chitosan composite coating and preparation method thereof
  • Hydroxyapatite/chitosan composite coating and preparation method thereof
  • Hydroxyapatite/chitosan composite coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Step 1: Pretreatment of biomedical metal substrates

[0032] (1) Using Ti6Al4V titanium alloy as the metal matrix, cut it into small blocks of 12mm×12mm×0.9mm.

[0033] (2) Polish with SiC sandpaper and ultrasonically clean with acetone and deionized water for 20 min each; then in 1.0M H 3 PO 4 Soak in -2wt.% HF solution for 5 minutes to form a TiOx layer on the surface of the titanium alloy; after acid treatment, clean it with deionized water and then ultrasonic cleaning with absolute ethanol.

[0034] (3) Dry at 60°C for use.

[0035] Step 2: Prepare a solution containing chitosan, calcium ions and phosphate ions

[0036] (1) Measure 10ml of glacial acetic acid and dilute to 500ml to obtain a 2vt.% dilute acetic acid solution.

[0037] (2) Take 100ml of 2vt.% glacial acetic acid solution, add 1.0g of chitosan, stir continuously to dissolve until clear and transparent.

[0038] (3) Weigh 2.3615g Ca(NO 3 ) 2 4H 2 O with 0.9342g NaH 2 PO 4 2H 2 A solution of O d...

Embodiment 2

[0047] Step 1: Pretreatment of biomedical metal substrates

[0048] (1) Using Ti6Al4V titanium alloy as the metal matrix, cut it into small blocks of 12mm×12mm×0.9mm.

[0049] (2) Polish with SiC sandpaper and ultrasonically clean with acetone and deionized water for 20 min each; then in 1.0M H 3 PO 4 Soak in -2wt.% HF solution for 5 minutes to form a TiOx layer on the surface of the titanium alloy; after acid treatment, clean it with deionized water and then ultrasonic cleaning with absolute ethanol.

[0050] (3) Dry at 60°C for use.

[0051] Step 2: Prepare a solution containing chitosan, calcium ions and phosphate ions

[0052] (1) Measure 20ml of glacial acetic acid and dilute to 500ml to obtain a 4vt.% dilute acetic acid solution.

[0053] (2) Take 100ml of 4vt.% glacial acetic acid solution, add 1.0g of chitosan, stir continuously to dissolve until clear and transparent.

[0054] (3) According to the molar ratio of calcium and phosphorus of 2:1, weigh 1.5614g CaF 2...

Embodiment 3

[0063] Step 1: Pretreatment of biomedical metal substrates

[0064] (1) Using Ti6Al4V titanium alloy as the metal matrix, cut it into small blocks of 12mm×12mm×0.9mm.

[0065] (2) Polish with SiC sandpaper and ultrasonically clean with acetone and deionized water for 20 min each; then in 1.0M H 3 PO 4 Soak in -2wt.% HF solution for 5 minutes to form a TiOx layer on the surface of the titanium alloy; after acid treatment, clean it with deionized water and then ultrasonic cleaning with absolute ethanol.

[0066] (3) Dry at 60°C for use.

[0067] Step 2: Prepare a solution containing chitosan, calcium ions and phosphate ions

[0068] (1) Measure 10ml of glacial acetic acid and dilute to 500ml to obtain a 2vt.% dilute acetic acid solution.

[0069] (2) Take 100ml of 2vt.% glacial acetic acid solution, add 1.0g of chitosan, stir continuously to dissolve until clear and transparent.

[0070] (3) Weigh 2.3615g Ca(NO 3 ) 2 4H 2 O with 0.9342g NaH 2 PO 4 2H 2 A solution of O...

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Abstract

The invention discloses a hydroxyapatite / chitosan composite coating and a preparation method thereof. The preparation process mainly comprises the following steps of: (1) preparing liquor containing chitosan, calcium ions and phosphate anions; (2) based on biomedical metal as a matrix, preparing a chitosan coating containing calcium ions and phosphate anions by a dipping-pulling method; and (3) converting the chitosan coating containing calcium ions and phosphate anions to the hydroxyapatite / chitosan composite coating by a biomineralization method. The coating prepared by the invention adequately combines advantages of the biomedical metal matrix, hydroxyapatite and chitosan. With the biomedical metal matrix, the coating has stronger mechanical property. With a porous structured formed by sequentially arranging sheet hydroxyapatite, the coating has good biocompatibility. Chitosan organic matters are introduced, so that not only is the binding capacity of hydroxyapatite and the metal matrix remarkably improved, but also the coating material is endowed with the antibacterial performance.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hydroxyapatite / chitosan composite coating and a preparation method thereof. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth. Because of its good biocompatibility and osteoinductive ability, it can form a tight chemical bond with human bone tissue at the interface after implanted in the human body, thereby inducing bone formation. The growth of tissue promotes bone repair, and it is a good hard tissue replacement material, which has been successfully applied in the fields of dentistry, plastic surgery and maxillofacial reconstruction. Chitosan (chitosan, CS) is the only natural alkaline polysaccharide that exists in nature. and biodegradability, etc., making it an ideal safe and reliable natural bioactive material for various tissue engineering and wound repair such as skin tissue engineering bone, cartilage, ne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/04
Inventor 郭亚平唐沙柯勤飞宋真富郭亚军
Owner SHANGHAI NORMAL UNIVERSITY
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