A kind of production equipment and production method of mesobiotics raw powder

A production method and technology of production equipment, applied in the field of production equipment of zhongshengmycin raw powder, can solve the problems of zhongshengmycin biological activity damage loss, serious material liquid loss, unformed filter cake, etc., and achieve product damage loss Less, mild process conditions, less artificial effect

Active Publication Date: 2015-10-21
福建凯立生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. After adding flocculation filter aid to the fermentation broth, it is difficult to filter the plate and frame, the filtration speed is slow, the filtration pressure is as high as 0.4-0.6Mpa, the filter cake is not formed, cannot be topped with water, blown dry, the loss of feed liquid is serious, and the filtration yield is low , the highest is only about 90%
[0006] 2. The fermentation liquid needs to add flocculation and filter aid, the viscosity concentration is high, and the labor intensity of dismantling the plate frame and cleaning the thinner liquid is high
[0007] 3. During the vacuum concentration process, the feed liquid needs to be kept at a high temperature of ≥60°C for 5-8 hours, resulting in serious damage to Zhongshengmycin’s biological activity and a low concentration yield, generally ≤85%.

Method used

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  • A kind of production equipment and production method of mesobiotics raw powder
  • A kind of production equipment and production method of mesobiotics raw powder

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Use 1000L of fermented liquid containing Zhongshengmycin with a concentration of 8.5g / L as the raw material, adjust the pH to 4.0; use a ceramic membrane with a pore size of 0.1um at room temperature, operate at a pressure of 0.25Mpa, add 2000L of acidic water for membrane filtration and dialysis and maintain pH4.0; the filtrate directly enters the nanofiltration system with a cutting molecular weight of 400Da for concentration, and the operating pressure is 2.0Mpa to obtain a concentrated solution of 100L. The potency of the concentrated solution is 77.5g / L. The total yield from the fermentation broth to the concentrated solution is: 91.18%; the concentrated solution was spray-dried to obtain 18.3kg of Zhongshengmycin raw powder, with a potency of 403,800 u / g, a spray yield of 95.35%, and a total product yield of 86.94%.

Embodiment 2

[0043]Use 1000L of fermented liquid containing Zhongshengmycin with a concentration of 9.6g / L as raw material, adjust the pH to 4.0; use a ceramic membrane with a pore size of 0.05um at room temperature, operate at a pressure of 0.3Mpa, add 2000L of acidic water for membrane filtration and dialysis and maintain pH4.0; the filtrate directly enters the nanofiltration system with a cutting molecular weight of 400Da for concentration, the operating pressure is 2.2Mpa, and 98L of concentration is obtained, the potency of the concentrate is 90.6g / L, and the total yield from the fermentation broth to the concentrate is: 92.49 %; the concentrated solution was spray-dried to obtain 18.7kg of Zhongshengmycin powder, with a potency of 455,800 u / g, and a spray yield of 96.00%; the total yield of the product was 88.79%.

Embodiment 3

[0045] Using 1000L of fermented liquid containing Zhongshengmycin with a concentration of 9.2g / L as raw material, adjust the pH to 4.0; use a ceramic membrane with a pore size of 0.1um at room temperature, operate at a pressure of 0.3Mpa, add 2000L of acidic water for membrane filtration and dialysis and maintain pH4.0; the filtrate directly enters the nanofiltration system with a cutting molecular weight of 400Da for concentration, and the operating pressure is 2.3Mpa to obtain a concentrated solution of 105L. The potency of the concentrated solution is 81.5g / L. The total yield from the fermentation broth to the concentrated solution is: 93.02%; the concentrated solution was spray-dried to obtain 17.5kg of Zhongshengmycin raw powder, the potency was 467,000 u / g, the spray yield: 95.50%; the total product yield: 88.83%.

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Abstract

The invention discloses a production device and a production method of zhongshengmycin soluble powder. The pH value of zhongshengmycin fermentation liquor is adjusted to be acidic, and the acidic fermentation liquor is directly fed into a ceramic membrane system to treat so as to remove solid impurities and obtain clear filter liquor; and the filter liquor is subjected to nanofiltration concentration at room temperature so as to obtain a zhongshengmycin concentrated solution for spraying, and the concentrated solution is subjected to spray drying so as to obtain the zhongshengmycin soluble powder. According to the invention, the labor intensity of workers is greatly reduced, and the yield of separation and concentration of zhongshengmycin and the final titer of soluble powder are increased.

Description

technical field [0001] The invention relates to the preparation of a biological pesticide, in particular to a production equipment and production method of Zhongshengmycin raw powder. Background technique [0002] According to the statistics of the Food and Agriculture Organization of the United Nations (FAO), in the process of agricultural and forestry production in the world, more than one-third of the losses caused by diseases, insect pests and weeds are caused every year. About 3 million cases of chemical pesticide poisoning occur every year in the world. In developing countries, there are about 1,650 mass poisoning incidents worldwide each year caused by eating pesticide-contaminated food. Therefore, vigorously developing biopesticides that are safe, low-toxic or non-toxic, and environmentally friendly and compatible has become an inevitable trend and a global consensus. Zhongshengmycin is a new type of agricultural antibiotic biopesticide. Its application belongs to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/02C07H1/06
Inventor 陈灼湖赵立平温锦奋
Owner 福建凯立生物制品有限公司
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