Endellite composite chitosan haemostasis and wound restoration sponge material, preparation and applications

A technology of wound repair and chitosan, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of unsatisfactory hemostatic effect, difficult molding, and poor mechanical properties of halloysite nanotubes, so as to promote healing ability, Low cost, good toughness

Inactive Publication Date: 2013-09-25
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The invention combines chitosan and halloysite nanotubes, not only can effectively overcome the defect of unsatisfactory hemostatic effect of simple chitosan hemostatic sponge, but also can o

Method used

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  • Endellite composite chitosan haemostasis and wound restoration sponge material, preparation and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 1g of chitosan (95% degree of deacetylation) in 50mL of deionized water, add 1mL of glacial acetic acid and stir to dissolve chitosan evenly, and obtain a mass volume ratio (g / mL) of chitosan to dilute acid solution of 1 : 51 dilute chitosan acid solution; weigh 0.01g of halloysite nanotubes after purification and sterilization (water dispersion precipitation centrifugation and Co60 radiation sterilization (15kGy×0.5h)), add to the mass volume Chitosan dilute acid solution with a ratio (g / mL) of 1:51 was stirred and mixed evenly at room temperature; Thick porous sponge solids, neutralized with 2% sodium hydroxide lye, washed with sterile water, then freeze-dried at -80°C for 24 hours and sterilized with Co60 radiation at a dose of 60Co rays and 15kGy for 0.5 hours. That is, the halloysite composite chitosan hemostasis and wound repair sponge material is obtained.

Embodiment 2

[0031] Weigh 1 g of chitosan (deacetylation degree 70%) in 50 mL of deionized water, add 1 mL of hydrochloric acid and stir to dissolve chitosan evenly, and obtain the mass volume ratio (g / mL) of chitosan to dilute acid solution as 1: 51 dilute chitosan acid solution; weigh 4g of halloysite nanotubes after purification and sterilization (water dispersion precipitation centrifugation and Co60 radiation sterilization (15kGy×0.5h)), add to the mass volume ratio ( g / mL) chitosan dilute acid solution of 1:51, stirred and mixed evenly at room temperature; the resulting solution was divided into circular plastic molds, frozen at -196°C for 24h, and then freeze-dried at -80°C for 24h to obtain A certain thickness of porous sponge solid, then neutralized with 2% sodium hydroxide lye, washed with sterile water, then freeze-dried at -80°C for 24 hours and sterilized with 15kGy of Co60 radiation for 0.5 hours, that is Obtain halloysite composite chitosan hemostatic and wound repair sponge...

Embodiment 3

[0033] Weigh 1g of chitosan (98% degree of deacetylation) into 50mL of deionized water, add 1mL of glacial acetic acid and stir to dissolve chitosan evenly, and obtain a mass volume ratio (g / mL) of chitosan to dilute acid solution of 1 : 51 dilute chitosan acid solution; weigh 0.5g of halloysite nanotubes after purification and sterilization (water dispersion precipitation centrifugation and Co60 radiation sterilization (15kGy×0.5h)), add to the mass volume Chitosan dilute acid solution with a ratio (g / mL) of 1:51, stirred and mixed evenly at room temperature; the resulting solution was divided into small containers, frozen at -80°C for 24h, and then freeze-dried at -80°C for 24h to obtain Porous sponge solid of a certain thickness. The obtained sponge solid was neutralized with 2% sodium hydroxide lye, washed several times with sterilized water, then freeze-dried at -80°C for 48 hours, and finally sterilized by 15 kGy of Co60 radiation. The hemostatic sponge was obtained in ...

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Abstract

The invention discloses an endellite composite chitosan haemostasis and wound restoration sponge material, preparation and applications, belonging to a biomedical material field The endellite composite chitosan haemostasis and wound restoration sponge material is prepared by the following steps of: uniformly dissolving chitosan into a dilute acid solution, adding endellite nanotube powder in a mass ratio 100:1-1:4 of chitosan to endellite nanotubes, stirring to uniformly mix, freezing under a freezing point, neutralizing with an alkali solution and washing with sterile water after freezing and drying, carrying out freezing and drying treatment, and then obtaining the endellite composite chitosan haemostasis and wound restoration sponge material after radiation disinfection. The endellite composite chitosan material has good effect for haemostasis and wound restoration, and can be applied in a haemostasis and wound restoration material; and chitosan and endellite nanotubes are used as raw materials, and the endellite composite chitosan haemostasis and wound restoration sponge material has advantages of simple preparation method and technology, and low cost.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a halloysite composite chitosan hemostatic and wound repairing sponge material and its preparation and application. Background technique [0002] Trauma is one of the main causes of human death, and there are as many as 5 million deaths worldwide due to trauma every year. Whether it is a trauma in an accident or a trauma during an operation, rapid and effective hemostasis is the first step in rescue and is very important to reduce trauma mortality. Therefore, the research and development of hemostatic materials is of great significance. Among them, chitosan rapid hemostatic material is a hot spot in the research of hemostatic materials. [0003] Chitosan is a natural polycationic polysaccharide obtained by deacetylation of chitin, and its chemical name is (1,4)-2-amino-2-deoxy-B-D-glucan. Chitosan has various functions such as antibacterial and anti-inflammatory...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/42C08J9/26C08J3/28C08L5/08C08K9/00C08K7/00C08K3/34
Inventor 刘明贤周长忍敖鹏黄健东
Owner JINAN UNIVERSITY
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