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Cefaclor granule and preparation method thereof

A technology of Clorox granules and cefaclor, which is applied in the field of medicine, can solve the problems of layering, affecting drug efficacy, and poor suspension effect of the solution, and achieves the effects of simple preparation process, improved stability, and good water solubility

Active Publication Date: 2013-10-02
ZHEJIANG ANGLIKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The quality of cefaclor raw materials is unstable and easy to degrade under humid and hot conditions. Therefore, the quality stability of cefaclor preparations currently on the market is generally poor, and the preparations need to be kept away from light and sealed.
In addition, because cefaclor is slightly soluble in water, its granules usually have the problem of poor suspension effect. After adding a certain amount of water to dissolve, the suspension effect of the solution is poor and stratification occurs, and it is difficult to ensure the dosage when taking it. affect the efficacy of the drug

Method used

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  • Cefaclor granule and preparation method thereof
  • Cefaclor granule and preparation method thereof
  • Cefaclor granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019] Preparation Process:

[0020] Pass cefaclor through a 100 mesh sieve, dissolve Kollicoat IR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, and mix the dried granules with sucrose, albino Spartame and sweet orange essence are mixed evenly and packaged.

Embodiment 2

[0022]

[0023] Preparation Process:

[0024] Pass cefaclor through a 100 mesh sieve, dissolve Kollicoat IR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, mix the dried granules with mannitol, Lactose, cyclamate, and mint essence are mixed evenly and packaged.

Embodiment 3

[0026]

[0027]

[0028] Preparation Process:

[0029] Pass cefaclor through a 100 mesh sieve, dissolve Kollicoat IR (3:1) in absolute ethanol, add cefaclor, stir evenly and dry under reduced pressure to remove ethanol, mix the dried granules with mannitol, sucrose, aspartame Sweet mix well, pack.

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PUM

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Abstract

The invention discloses a cefaclor granule and a preparation method thereof. The cefaclor granule is prepared by mixing a cefaclor granule clathrate compound with pharmaceutically acceptable auxiliary materials. The cefaclor granule clathrate compound is prepared by following steps: dissolving polyvinyl alcohol-polyethylene glycol graft copolymer (Kollicoat IR) in ethanol; adding cefaclor in the solution; and keeping stirring the solution and removing ethanol by vacuum drying method so as to obtain the cefaclor granule clathrate compound. Stability and dissolution rate of the cefaclor granule are high, production technology is simple, and the cefaclor granule is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cefaclor granule and a preparation method thereof. Background technique [0002] Cephalosporins play a bactericidal effect by inhibiting bacterial cell wall synthesis and are stable to most β-lactamases. Many strains producing penicillinase and cephalosporinase are still sensitive to cephalosporins. Cephalosporins in vitro and in vivo against Gram-positive cocci such as pneumococcus, Streptococcus pyogenes, Gram-negative bacilli such as influenza bacilli (including enzyme-producing strains), Moraxella catarrhalis (including enzyme-producing strains) , Escherichia coli, Proteus mirabilis, and Neisseria gonorrhoeae (including enzyme-producing strains) all have good antibacterial effects. Effects of cephalosporins on Streptococcus pneumoniae, Bacillus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Pasteurella multocida, Providencia sp., Salmonella sp., Shig...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/545A61K47/30A61P31/04
Inventor 蒋林波陈杰赵明馨
Owner ZHEJIANG ANGLIKANG PHARMA
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