Corydalisdecumbens(Thunb.)Pers. injection and preparation method thereof

A technology for injection and filtrate, which is used in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc.

Active Publication Date: 2013-10-23
JIANGXI HERBI SKY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many adverse reactions of traditional Chinese medicine injections are caused by cosolvents or solubilizers. Th

Method used

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  • Corydalisdecumbens(Thunb.)Pers. injection and preparation method thereof
  • Corydalisdecumbens(Thunb.)Pers. injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 summer without injection

[0015] Take Xia Tian, ​​grind it into a coarse powder, follow the percolation method under the item of liquid extract and extract (Appendix 10 of "Chinese Pharmacopoeia" 2010 edition), soak with 1% hydrochloric acid for 48 hours, and then percolate until the alkaloid After the extraction is complete, the obtained percolation liquid passes through the pre-treated cation exchange resin for ion exchange until the effluent of the exchange column begins to show a positive reaction of alkaloids, and then rinses with water until there is no chloride ion reaction, and the resin is dried in the air. Use alkaline ethanol (add ammonia test solution to the ethanol to adjust the pH value to 9-10) and reflux for elution several times until the eluent shows a negative reaction with alkaloids, combine the eluent, recover ethanol and concentrate it into a liquid extract, and use it in Dry below 80°C, add 20 times the amount of water for injection ...

experiment example 1

[0017] Experimental Example 1 Anti-inflammation Experimental Research without Injection in Summer

[0018] 1. The effect of p-xylene on ear swelling in mice

[0019] Twenty-eight mice weighing 20-25 g, both male and female, were randomly divided into two groups, and were injected intraperitoneally with 10 mg of total alkaloids / kg of summer-free injection and equal volume of normal saline, and 0.04 ml of the pro-inflammatory agent xylene was evenly injected 20 minutes later. Apply to both sides of the left ear of the mouse, and the right ear is used as a control. The mice were killed after 30 minutes of inflammation, and the left and right ears were weighed with a puncher with a diameter of 8 mm. The difference between the weights of the two ears was used as the index of inflammatory swelling. The t test was used for comparison between the two groups. The results are shown in Table 1. Xia Tianwu injection had a significant inhibitory effect on the inflammatory swelling of the ...

Embodiment 2

[0034] Embodiment 2 summer without injection

[0035] Take Xia Tian, ​​grind it into a coarse powder, add 12 times the amount of 1% hydrochloric acid solution to decoct and extract 3 times, the first time for 1.5 hours, and the second time for 1 hour each, combine the decoction liquid, let it cool, filter, and the filtrate passes through the pre- The treated cation exchange resin is subjected to ion exchange until the effluent of the exchange column begins to show a positive reaction of alkaloids, and then rinses with water until there is no chloride ion reaction, and then the resin is dried with alkaline ethanol (adding ammonia to ethanol) Adjust the pH value of the test solution to 9-10) and reflux and elute in several times until the eluent shows alkaloid negative reaction, combine the eluent, recover ethanol and concentrate it to a fluid extract with a relative density of 1.30-1.35 (60°C), Add 15 times the amount of water for injection, heat and stir, and slowly add an app...

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Abstract

The invention discloses a Corydalisdecumbens(Thunb.)Pers. injection and a preparation method thereof. The Corydalisdecumbens(Thunb.)Pers. injection is a sterile aqueous solution prepared by Corydalisdecumbens(Thunb.)Pers. extraction. Each milliliter of the Corydalisdecumbens(Thunb.)Pers. injection contains greater than or equal to 0.17mg of macleyine, greater than or equal to 0.02mg of tetrahydropalmatine, less than or equal to 0.03mg of bicuculline and less than or equal to 0.02mg of decumbenine. The Corydalisdecumbens(Thunb.)Pers. injection has good stability and is safe and effective.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a summer-free injection and a preparation method thereof. Background technique [0002] In summer, the dry tuber of Corydalis decumbens (Thunb.) Pers., a plant of the family Poppyaceae, has the effects of promoting blood circulation, dredging collaterals, promoting Qi and relieving pain, and can be used to treat stroke hemiplegia, injury from falls, rheumatoid arthritis, and sciatica. Since the 1970s, scholars at home and abroad have conducted systematic research on its chemical composition, pharmacological activity, and clinical efficacy. Studies have shown that the active ingredients in summer are mainly alkaloids. At present, there are three types of Xiawu preparations in clinical use, including external use, oral administration and injection. Compared with other dosage forms, the injection has the advantages of fast onset of action and high bioavailability. [00...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/08A61P29/00A61P9/10A61P19/02A61P25/02
Inventor 吴安明吴朝阳吴孔松何杨虎段国华徐岚梅星红
Owner JIANGXI HERBI SKY CO LTD
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