Preparation method of cinnamon polyphenol extract

The technology of extract and cinnamon is applied in the field of preparation of cinnamon polyphenol extract, which can solve the problems of complex preparation process, unfavorable batch production and the like, and achieve the effects of low preparation cost and simple preparation method.

Inactive Publication Date: 2013-10-30
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patented technology makes the total polyphenol content in the obtained cinnamon polyphenol extract reach more than 26wt%, the preparation process is complicated, which is not conducive to industrialized batch production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a) Warm soaking and extracting the cinnamon medicinal material with an acetone aqueous solution with a volume concentration of 70%, wherein 1 g of the cinnamon medicinal material is extracted with 50 ml of acetone aqueous solution; the warm soaking temperature is controlled at 45° C., and the warm soaking is 0.5 hours, and the warm soaking is extracted once;

[0023] b) distilling off the acetone in the extract under reduced pressure, then adding an appropriate amount of water to dilute the concentrate to obtain a crude extract;

[0024] c) Extracting the crude extract with petroleum ether, the volume of petroleum ether used each time is 1.5 times the volume of the crude extract, extracting 3 times in total, and collecting the extracted aqueous layer;

[0025] d) extract the collected water layer with ethyl acetate, the volume of ethyl acetate used in each extraction is 1.5 times the volume of the extracted water layer, extract 3 times in total, combine the ethyl acetate...

Embodiment 2

[0028] a) Carry out reflux extraction of the cinnamon medicinal material with an acetone aqueous solution with a volume concentration of 50%, wherein 1 g of the cinnamon medicinal material is refluxed with 25 ml of acetone aqueous solution; reflux for 2 hours each time, and a total of reflux extraction 2 times;

[0029] b) distilling off the acetone in the extract under reduced pressure, then adding an appropriate amount of water to dilute the concentrate to obtain a crude extract;

[0030] c) Extracting the crude extract with petroleum ether, the volume of petroleum ether used each time is 1 times the volume of the crude extract, extracting 4 times in total, and collecting the extracted aqueous layer;

[0031] d) extract the collected water layer with ethyl acetate, the volume of ethyl acetate used for each extraction is 1 times of the volume of the extracted water layer, extract 4 times in total, combine the ethyl acetate layers obtained by extraction, and distill under reduc...

Embodiment 3

[0034] a) Carry out reflux extraction of the cinnamon medicinal material with an aqueous acetone solution with a volume concentration of 20%, wherein 1 g of the cinnamon medicinal material is extracted with 5 ml of acetone aqueous solution; reflux for 1 hour each time, and a total of 3 times of reflux extraction;

[0035] b) distilling off the acetone in the extract under reduced pressure, then adding an appropriate amount of water to dilute the concentrate to obtain a crude extract;

[0036] c) Extracting the crude extract with petroleum ether, the volume of petroleum ether used each time is 0.5 times the volume of the crude extract, and extracting 6 times in total, collecting the extracted aqueous layer;

[0037] d) extract the collected water layer with ethyl acetate, the volume of ethyl acetate used in each extraction is 0.5 times of the volume of the extracted water layer, extract 6 times in total, combine the ethyl acetate layers obtained by extraction, and distill under ...

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Abstract

The invention discloses a preparation method of a cinnamon polyphenol extract. The method comprises the following steps of: extracting cinnamon with ethanol water or acetone water; removing ethanol or acetone in the extracting solution by a reduced pressure distillation method, then adding a proper amount of water and diluting concentrated liquor to obtain crude extract; extracting the crude extract with petroleum ether, diethyl ether or methylene dichloride and collecting a water layer obtained from extraction; and extracting the collected water layer with ethyl acetate, combining an ethyl acetate layer obtained from extraction, removing the ethyl acetate by a reduced pressure distillation method, and drying to obtain solid powder of the cinnamon polyphenol extract. The preparation method is simple, does not need special equipment or complex technological condition, is low in preparation cost, and accords with the requirement of industrial batch production. The content of total polyphenol in the cinnamon polyphenol extract is as high as 30-40wt%, and hypoglycemic drug preparation can be developed so as to sufficiently guarantee application research of the cinnamon polyphenol extract.

Description

technical field [0001] The invention relates to a preparation method of cinnamon polyphenol extract, which belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Cinnamon is the dry bark of Cinnamomum cassia Presl, a plant in the Lauraceae family. It is a commonly used Chinese herbal medicine. It has a long history as a spice and medicinal. The earliest record comes from "Shen Nong's Herbal Classic", which says "Gui is the best of all medicines" statement. Cinnamon is pungent in nature and flavor, sweet, and very hot, and returns to the kidney, spleen, heart, and liver channels. Previous studies on the chemistry and pharmacology of cinnamon mainly focused on the fat-soluble parts and cinnamon aldehyde components, and found that they have antibacterial, anti-ulcer, blood vessel expansion, platelet viscosity reduction, and anti-inflammatory activities, but there are very few studies on other parts. [0003] In 2001, Professo...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P3/10
Inventor 李医明贾琦陈亮张勇陈凯先
Owner SHANGHAI UNIV OF T C M
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