Tissue engineering double-layered tubular support and preparation method thereof
A tissue engineering and tubular technology, applied in the field of tissue engineering tubular stent and its preparation, can solve the problems that the mechanical properties are difficult to satisfy the tubular tissue, the stent has a single component, etc., and achieves the effects of low preparation cost, simple operation, and improved overall mechanical properties.
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[0026] Example 1
[0027] The inner layer structure is PLLA / PLCL dense nanofiber structure, and the outer layer structure is a double-layer tubular stent of PLLA / PCL self-forming system.
[0028] (1) Dissolve PLLA and PLCL in tetrahydrofuran at a mass ratio of 40:60 at 55°C, and stir to prepare a 10% (w / v) uniform solution;
[0029] (2) Cast the PLLA / PLCL mixed solution into a polytetrafluoroethylene mold, and quickly place it at -80°C for phase separation, overnight;
[0030] (3) Take out the mold from the low temperature, and withdraw the mold, soak the gel polymer in the deionized ice water mixture to exchange the solvent for 2 days, and change the deionized ice water 3 times a day;
[0031] (4) Take out the tubular stent from deionized water and freeze-dry to obtain a PLLA / PLCL nanofiber tubular stent with dense structure;
[0032] (5) Put the dense nanofiber tubular scaffold prepared in (4) on the core column of the polytetrafluoroethylene mold, and assemble a new set of casting mol...
Example Embodiment
[0037] Example 2
[0038] The inner layer structure is a PLLA / PLCL dense nanofiber structure, and the outer layer structure is a double-layer tubular scaffold with a PLLA porous nanofiber structure that is pore-induced by sugar balls.
[0039] (1) Dissolve PLLA and PLCL in tetrahydrofuran at a mass ratio of 70:30 at 55°C, stir to prepare a 10% (w / v) uniform solution;
[0040] (2) Cast the PLLA / PLCL mixed solution into a polytetrafluoroethylene mold, and quickly place it at -20°C to separate the phases overnight;
[0041] (3) Take out the mold from the low temperature, and withdraw the mold, soak the gel polymer in deionized ice water to exchange the solvent for 2 days, and change the deionized ice water 3 times a day;
[0042] (4) Take out the tubular stent from deionized water and freeze-dry to obtain a PLLA / PLCL nanofiber tubular stent with dense structure;
[0043] (5) Put the dense nanofiber tubular scaffold prepared in (4) on the core column of the polytetrafluoroethylene mold, and ...
Example Embodiment
[0050] Example 3
[0051] The inner layer structure is a PLLA / PLCL dense nanofiber structure, and the outer layer structure is a double-layer tubular scaffold with a PLLA porous nanofiber structure prepared by a gas foaming method.
[0052] (1) Dissolve PLLA and PLCL in tetrahydrofuran at a mass ratio of 50:50 at 55°C, stir to prepare a 10% (w / v) uniform solution;
[0053] (2) Cast the PLLA / PLCL mixed solution into a polytetrafluoroethylene mold, and quickly place it at -80°C for phase separation, overnight;
[0054] (3) Take out the mold from the low temperature, and withdraw the mold, soak the gel polymer in deionized ice water to exchange the solvent for 2 days, and change the deionized ice water 3 times a day;
[0055] (4) Take out the tubular stent from deionized water and freeze-dry to obtain a PLLA / PLCL nanofiber tubular stent with dense structure;
[0056] (5) Put the dense nanofiber tubular scaffold prepared in (4) on the core column of the polytetrafluoroethylene mold, and asse...
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