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Memantine hydrochloride slow-release dry suspension and preparation method thereof
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A technology of memantine hydrochloride and dry suspension is applied in the direction of making medicines into special physical or taking form devices, amine active ingredients, powder delivery, etc. problems, to achieve stable blood drug concentration levels, easy operation and control, and the effect of solving effectiveness
Active Publication Date: 2017-09-12
HAINAN PULIN PHARMA +1
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Problems solved by technology
The domestic and foreign patents of memantine hydrochloride retrieved above are mainly patents related to ordinary tablets, sustained-release capsules and sustained-release tablets, and there are no reports related to sustained-release dry suspensions
Method used
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[0037] (1) Preparation of memantine hydrochloride-ion exchange resin complex: Add the prescribed amount of styrene weakly acidic cation exchange resin into a blender filled with deionized water, add memantine hydrochloride and stir evenly while stirring, and continue Stir for 3 hours at a speed of 600 rpm, then stand still to allow the drug resin to precipitate, filter, take out the precipitate, put it in a ...
[0070] The preparation process is basically the same as the examples.
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Abstract
The invention relates to memantinehydrochloride sustained-release dry suspension and a preparation method thereof. Materials including the following weight ratios are: memantinehydrochloride 5%~20%, ion exchange resin 10%~40%, hydrophilic or water-soluble excipients 0.5%~10%, coating materials 5%~20%, other excipients 10%~50%. The memantinehydrochloride sustained-release dry suspension of the present invention has a simple preparation process, is easy to operate and control, and is suitable for large-scale industrial production. The obtained memantine hydrochloride sustained-release dry suspension has a relatively stable drug release rate and a high cumulative release rate. The drug rate, stable blood drug concentration level after taking it, effectively reducing the number of times patients take it and reducing toxic and side effects, while solving the effectiveness, safety and compliance of the elderly drug use.
Description
technical field [0001] The invention relates to pharmaceutical preparations, in particular to memantine hydrochloride sustained-release dry suspension for treating Alzheimer's disease and a preparation method thereof. Background technique [0002] Alzheimer's disease is one of the common diseases of the elderly, mainly manifested as memory loss and recognition impairment, etc., and is a progressive neurodegenerative disorder. Alzheimer's disease can be divided into Alzheimer's disease (AD), vascular dementia and mixed dementia. AD is the main type of Alzheimer's disease. With the aging of the world's population and the improvement of people's living standards, the average life expectancy is also extended. In 2002, the elderly over the age of 60 accounted for 20% of the world's total population. By 2050, the number of elderly people It is expected to reach 21% of the world's total population. With the aging of the world's population, senile dementia has become the primary p...
Claims
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Application Information
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