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Method for extracting fibrauretine from berberine production waste fluid

A technology of berberine and patulin, applied in the field of chemical preparation, can solve the problems of increasing the extraction cost of berberine, waste of resources and the like, and achieve the effects of low production cost, easy operation and simple process engineering

Inactive Publication Date: 2013-12-18
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for a long time these alkaloids were discarded along with other waste
This not only wastes the existing resources, but also increases the extraction cost of berberine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 500mL of berberine production waste liquid, add sodium hydroxide to adjust the pH value to between 8 and 9, and then filter; Sodium chloride equivalent to 15% of the mass of system A was salted out for 24 hours and then filtered; after the filtrate was concentrated to 2 / 3 of water, the pH value was adjusted to 2 to 3, and then placed overnight and filtered to obtain jatrorrhizine precipitation; the obtained drug Add water equivalent to 10 times the quality of the jatrorrhizine precipitation and dimethyl sulfate 3.3 times the quality of the jatrorrhizine precipitation, and slowly add 30% dimethyl sulfate equivalent to 4.5 times the quality of the jatrorrhizine precipitation after stirring evenly. Sodium hydroxide aqueous solution to obtain system B; transfer system B to a water bath heating device, and stir in a water bath at 30-35°C for 20 minutes, at 40-45°C for 20 minutes, and at 55-60°C for 20 minutes, Then adjust the pH value to between 2 and 3 to obtain system...

Embodiment 2

[0023] Take 2000mL of berberine production waste liquid, add sodium hydroxide to adjust the pH value to 8-9, and then filter; Sodium chloride equivalent to 15% of the mass of system A was salted out for 24 hours and then filtered; after the filtrate was concentrated to 2 / 3 of water, the pH value was adjusted to 2 to 3, and then placed overnight and filtered to obtain jatrorrhizine precipitation; the obtained drug Add water equivalent to 10 times the quality of the jatrorrhizine precipitation and dimethyl sulfate 3.3 times the quality of the jatrorrhizine precipitation, and slowly add 30% dimethyl sulfate equivalent to 4.5 times the quality of the jatrorrhizine precipitation after stirring evenly. Sodium hydroxide aqueous solution to obtain system B; transfer system B to a water bath heating device, and stir in a water bath at 30-35°C for 20 minutes, at 40-45°C for 20 minutes, and at 55-60°C for 20 minutes, Then adjust the pH value to between 2 and 3 to obtain system C; cool an...

Embodiment 3

[0025] Take 5000mL of berberine production waste liquid, add sodium hydroxide to adjust the pH value to between 8 and 9, and then filter; Sodium chloride equivalent to 15% of the mass of system A was salted out for 24 hours and then filtered; after the filtrate was concentrated to 2 / 3 of water, the pH value was adjusted to 2 to 3, and then placed overnight and filtered to obtain jatrorrhizine precipitation; the obtained drug Add water equivalent to 10 times the quality of the jatrorrhizine precipitation and dimethyl sulfate 3.3 times the quality of the jatrorrhizine precipitation, and slowly add 30% dimethyl sulfate equivalent to 4.5 times the quality of the jatrorrhizine precipitation after stirring evenly. Sodium hydroxide aqueous solution to obtain system B; transfer system B to a water bath heating device, and stir in a water bath at 30-35°C for 20 minutes, at 40-45°C for 20 minutes, and at 55-60°C for 20 minutes, Then adjust the pH value to between 2 and 3 to obtain syste...

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PUM

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Abstract

The invention discloses a method for extracting fibrauretine from berberine production waste fluid. The method comprises the following processes of: based on the berberine production waste fluid as a raw material, adding sodium hydroxide to regulate pH, performing salting out to obtain jatrorrhizine sediment, and adding dimethyl sulfate into the jatrorrhizine sediment for realizing methylation to obtain the fibrauretine. The method has the advantage of reusing the berberine production waste fluid and lowering production cost, and the method for preparing the fibrauretine is simple and easy to operate, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of chemical medicine preparation and relates to a preparation method of palmatine. Background technique [0002] The chemical name of palmatine is 5,6-dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinazine ylide, which has a broad-spectrum antibacterial effect and can be used clinically to treat Gynecological inflammation, bacillary dysentery, enteritis, respiratory tract and urinary tract infection, surgical infection and conjunctivitis, etc. Lutein can be extracted and refined from the dried cane of Caulis Fibraurear, a plant of the family Fangjiceae, but resources are scarce and supply is in short supply. [0003] Berberine is an important alkaloid that has been clinically used in my country for a long time. It is mainly extracted from plants such as Coptis chinensis, Cortex Phellodendron, Three Needles, and Shigonggong. According to literature records, these plants contain not only a certain amount of ber...

Claims

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Application Information

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IPC IPC(8): C07D455/03
Inventor 谭睿吴梅顾健陈家渊
Owner SOUTHWEST JIAOTONG UNIV
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