Diabetes-inducing high-fat feed and application thereof to preparation of diabetic foot ulcer rat experimental model

Abstract

The invention discloses a diabetes-inducing high-fat feed. The high-fat feed is prepared from the following components according to weight percentage: 73 percent of basal feed, 20 percent of lard oil, 2 percent of milk powder, 1 percent of cholesterol and 4 percent of saccharose, wherein the basal feed is prepared from the following components according to weight percentage: 15 percent of barley, 31 percent of wheat, 15 percent of corns, 15 percent of bran, 6 percent of fish meal and 18 percent of bean pulp, oil and salt. In addition, the invention also discloses application of the high-fat feed to preparation of a diabetic foot ulcer rat experimental model. The high-fat feed is used for preparing the diabetic foot ulcer rat experimental model. The diabetic ulcer animal experimental model detects the change of biochemical criteria after drug intervention, and a result shows that the model has the characteristic of diabetic foot ulcer, the ulcer wound healing time is long, the model is sensitive to drugs, and the like.

Description

technical field [0001] The invention belongs to the field of experimental animal models, in particular to a high-fat feed for inducing diabetes and its application in preparing an experimental model of diabetic foot ulcer rats. Background technique [0002] With the sharp increase in the incidence of diabetes in my country, the number of patients with diabetic ulcers has also increased. The establishment of a disease model that truly simulates diabetic ulcers at the overall animal level is a medical study to explore the pathogenesis of diabetic ulcers and preclinical pharmacodynamic evaluation. It is of great scientific and clinical significance. [0003] At present, the animal models of diabetic foot ulcers are mostly induced animal models. The results of literature studies show that the existing animal models of diabetic foot ulcers mostly simulate the arterial disease, neuropathy or infection of diabetic foot disease. Due to the different research purposes, the model esta...

AI Technical Summary

Problems solved by technology

The results of literature research show that the existing animal models of diabetic foot ulcers mostly simulate the arterial disease, neuropathy or infection of diabetic foot. Due to the different research purposes, the methods of establishing the models are various, and the differences between the models are quite large. There is a large gap with the actual clinical performance

Images