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Metformin hydrochloride dry suspension and preparation method thereof
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A kind of technology of dry metformin hydrochloride and metformin hydrochloride
Inactive Publication Date: 2013-12-25
天津市聚星康华医药科技有限公司
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[0006] Chinese patent CN101198319B discloses a granule preparation containing a biguanide compound, which is a granule preparation containing a biguanide compound and an anticoagulant, but its preparation process requires the use of a fluidized bed granulator for granulation, and involves a variety of auxiliary materials, production process More complicated and more expensive
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Embodiment 1
[0022] Each bag contains 250mg of metformin hydrochloride, and its prescription is:
[0023]
[0024] The preparation process is as follows:
[0025] Pass the metformin hydrochloride and the above-mentioned excipients through an 80-mesh sieve, then mix them uniformly, add an appropriate amount of 3% hydroxypropylmethyl cellulose (E-15)-60% ethanol solution to granulate, dry at 50℃, and use a 40-mesh sieveSizing to obtain a dry suspension of metformin hydrochloride.
[0026] Evaluation: Weigh 1g of dry suspension of metformin hydrochloride and add 20g of hot water to make it uniformly dispersed. The particle size is large, the sedimentation is fast at the beginning, and the suspension is better after 30 minutes. The taste is bitter and has peculiar smell.
Embodiment 2
[0028] Each bag contains 250mg of metformin hydrochloride, and its prescription is:
[0029]
[0030] The preparation process is as follows:
[0031] Pass the metformin hydrochloride and the above-mentioned excipients through an 80-mesh sieve, then mix them evenly, add an appropriate amount of 3% hydroxypropylmethyl cellulose (E-15)-60% ethanol solution to granulate, dry at 50℃, use a 40-mesh sieve Sizing to obtain a dry suspension of metformin hydrochloride.
[0032] Evaluation: Weigh 1g of dry suspension of metformin hydrochloride and add 20g of hot water to make it uniformly dispersed. The particle size is large, the suspension state is not good, the taste is bitter, and there is a peculiar smell.
Embodiment 3
[0034] Each bag contains 250mg of metformin hydrochloride, and its prescription is:
[0035]
[0036] The preparation process is as follows:
[0037] The metformin hydrochloride and the above-mentioned auxiliary materials are passed through an 80-mesh sieve and mixed uniformly to prepare a dry suspension of metformin hydrochloride.
[0038] Evaluation: Weigh 1g of dry suspension of metformin hydrochloride and add 20g of hot water to make it evenly dispersed. The suspension state is not good, the sedimentation is relatively fast, the taste is bitter, and there is a peculiar smell.
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Abstract
The invention belongs to the technical field of medicines and particularly relates to metforminhydrochloride dry suspension and a preparation method thereof. The metforminhydrochloride dry suspension is used for type-2 diabetes mellitus patients unsatisfied with pure diet control, particularly for obese patients accompanied by hyperinsulinemia, has the effect of reducing blood sugar and possibly has the effects of reducing weight and alleviating the hyperinsulinemia. The metforminhydrochloride dry suspension can take effect for certain patients with poor sulfonylureacurative effect. If the metformin hydrochloride dry suspension is used together with sulfonylurea, small intestine glycosidase inhibitors or thiazolidinediones hypoglycemic drugs, the effect is better than the effect achieved by single application. The metformin hydrochloride dry suspension can also be used for patients receiving insulin treatment so as to reduce the dosage of insulin. The metformin hydrochloride dry suspension has relatively good taste, is particularly suitable for child patients and fills in the blank of domestic child diabetes medication. The preparation technology of the metformin hydrochloride dry suspension is simple, convenient and practical.
Description
Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a dry suspension of metformin hydrochloride and a preparation method thereof. It is used for type 2 diabetic patients who are not satisfied with simple diet control, especially obesity and hyperinsulinemia. The drug not only reduces The effect of blood sugar may also have the effect of weight loss and hyperinsulinemia. It can be effective for patients with poor efficacy of certain sulfonylureas, such as combined use with sulfonylureas, intestinal glycosidase inhibitors, or thiazolidinedione hypoglycemic agents, which are more effective than separate use. It can also be used for patients undergoing insulin therapy to reduce the amount of insulin. Background technique [0002] Diabetes is a chronic disease of carbohydrate, fat and proteinmetabolism disorders caused by relative or absolute lack of insulin in the body or decreased sensitivity of target cells to insulin, or struc...
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Application Information
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