Allyl isothiocyanate-beta-cyclodextrin inclusion compound
A technology of cyclodextrin inclusion complex and isothiocyanate is applied in directions such as pharmaceutical combinations, ester active ingredients, and non-active ingredients medical preparations, etc. Bioavailability, ease of transport and preservation of use
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Embodiment 1
[0012] Example 1: Preparation of allyl isothiocyanate β-cyclodextrin inclusion compound
[0013] Add allyl isothiocyanate (100mg) dissolved in an organic solvent (absolute ethanol or acetone) to the aqueous solution of β-cyclodextrin, at a speed of 100-300r / min and a temperature of 30°C-60°C Stir at constant temperature for 1-3 hours, filter through a 0.22 μm microporous membrane, collect the filtrate, and dry in vacuum at low temperature for 5-6 hours to obtain the allyl isothiocyanate-β-cyclodextrin inclusion compound. Detected by ultraviolet light detection method, the content of allyl isothiocyanate in the obtained clathrate is calculated, and the inclusion yield is calculated (actually measured content of allyl isothiocyanate*inclusion compound yield / isothiocyanate Allyl ester input).
[0014] 1. Determine the proof that the product obtained in Example 1 forms an inclusion compound:
[0015] (1) Use thin-layer chromatography to determine whether clathrates are formed: ...
Embodiment 2
[0021] Example 2: Preparation of allyl isothiocyanate β-cyclodextrin inclusion compound
[0022] Dissolve 100mg of allyl isothiocyanate in 150mL ethanol solution to obtain allyl isothiocyanate dissolved in ethanol solution, set aside, then take 10g of β-cyclodextrin and dissolve in 1000mL of distilled water, magnetic stirring conditions at room temperature to Add allyl isothiocyanate ethanol solution to the saturated aqueous solution of β-cyclodextrin, continue to stir for 2 hours, let it stand overnight, evaporate the ethanol under reduced pressure, filter, and dry the filtrate under reduced pressure and low temperature to obtain allyl isothiocyanate The β-cyclodextrin inclusion compound is detected by ultraviolet spectroscopic detection method, and the content of allyl isothiocyanate in the obtained inclusion compound.
Embodiment 3
[0023] Example 3: Preparation of allyl isothiocyanate β-cyclodextrin inclusion compound
[0024] Dissolve 100mg of allyl isothiocyanate in 150mL of acetone solution to obtain allyl isothiocyanate dissolved in acetone solution, set aside, then take 10g of β-cyclodextrin dissolved in 1000mL of distilled water, ultrasonic vibration (ultrasonic frequency Add allyl isothiocyanate acetone solution to the β-cyclodextrin saturated aqueous solution under the condition of 40-60KHZ), continue ultrasonication for 1 hour, let stand overnight, evaporate ethanol under reduced pressure, filter, and dry the filtrate under reduced pressure and low temperature. It is confirmed by thin-layer chromatography that the inclusion compound of allyl isothiocyanate β-cyclodextrin is obtained, and the content of allyl isothiocyanate in the inclusion compound is detected by ultraviolet spectrum detection.
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