Intelligent anionic electric-field sensitive glycosyl hydrogel with block structure and preparation method of intelligent anionic electric-field sensitive glycosyl hydrogel
An anionic, segmental structure technology, applied in the field of block structure anionic electric field sensitive sugar-based smart hydrogel and its preparation, can solve the problems of unstable performance, poor mechanical strength, etc., and achieves improved biocompatibility, good Effects of Electric Field Response Behavior
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Embodiment 1
[0021] Synthesis of glucose-2-methacrylamide: In a 250 mL four-necked flask equipped with a thermometer reflux condenser, add 150 mL of methanol and 8.96 g (0.05 mol) of ground DL-2-glucosamine, add triethyl Amine 5.56 g (0.055 mol). At room temperature, 5.20 g (0.055 mol) of methacryloyl chloride was slowly added dropwise, and the reaction was continued after the dropwise addition was completed. After the reaction was monitored by TLC, 11.30 g of crude glucose-2-methacrylamide was obtained by filtration and rotary evaporation, with a yield of 91.6%.
Embodiment 2
[0023] Synthesis of dimethylbenzyl dithiobenzoate: 50 mL of dry tetrahydrofuran and 10.5 mL (0.10 mol) of bromobenzene were added to a constant pressure dropping funnel. In a 250mL four-neck flask equipped with a thermometer, add 2.50 g (0.105 mol, a little excess) of magnesium bars whose surface has been removed from the oxide layer, add a grain of iodine, and add 10 mL of the mixed solution dropwise under nitrogen protection. , After the reaction was initiated by slight heating, bromobenzene in tetrahydrofuran solution was added dropwise, and the reaction was completed for 2 h. The reaction system was cooled with an ice-water bath, and 9 mL of carbon disulfide and 50 mL of tetrahydrofuran were added to a constant-pressure dropping funnel. After the addition was complete, the temperature was raised to 50 °C for 1 h. Pour the reaction solution into a 250 mL round-bottomed flask while removing unreacted magnesium strips, and vacuum to remove THF. Add 50 mL of diethyl ether fir...
Embodiment 3
[0025] In a 250 mL four-neck flask equipped with a thermometer, add 100 ml of tetrahydrofuran, then add 10.0 g of glucose-2-methacrylamide and 0.2 g of dimethylbenzyl dithiobenzoate, and add The initiator azobisisobutyronitrile AIBN 0.05 g was reacted in a water bath at 70°C for 2 hours, and the polymerization of the sugar-based monomer was detected by TLC; then 10.0 g of comonomer AMPS was added, and the polymerization was continued at 70°C for 5 hours. Precipitate with methanol and dry to obtain 12.3 g of "glucosamine glycosyl-AMPS" block structure anionic electric field sensitive glycosyl hydrogel.
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