A block-structure anionic electric field-sensitive sugar-based smart hydrogel and its preparation method
An anionic, segment-structured technology, applied in the field of block-structured anionic electric-field-sensitive sugar-based smart hydrogel and its preparation, can solve the problems of poor mechanical strength and unstable performance, and achieve improved biocompatibility, good Effects of Electric Field Response Behavior
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Embodiment 1
[0021] Glucose-2-methylacrylamide synthesis: In a 250mL four-necked flask equipped with a thermometer reflux condenser, add 150mL methanol and 8.96g (0.05mol) of ground DL-2-glucosamine, add 5.56 triethylamine g(0.055mol). At room temperature, slowly drip 5.20 g (0.055 mol) of methacryloyl chloride, and continue the reaction after the addition is complete. After the reaction was monitored by TLC, 11.30 g of crude glucose-2-methacrylamide was obtained by filtration and rotary evaporation, with a yield of 91.6%.
Embodiment 2
[0023] Synthesis of dimethylbenzyl dithiobenzoate: 50mL dry tetrahydrofuran and 10.5mL (0.10mol) bromobenzene were added to a constant pressure dropping funnel. In a 250 mL four-necked flask equipped with a thermometer, add 2.50 g (0.105 mol, a slight excess) of magnesium bar with the oxide layer removed on the surface, add a grain of iodine, and add 10 mL of the mixed solution dropwise under the protection of nitrogen. After the reaction was initiated by slight heat, a solution of bromobenzene in tetrahydrofuran was added dropwise, and the reaction was completed for 2 hours. The reaction system was cooled with an ice-water bath, and 9 mL of carbon disulfide and 50 mL of tetrahydrofuran were added to the constant pressure dropping funnel. After the addition was completed, the temperature was raised to 50° C. and reacted for 1 hour. The reaction solution was poured into a 250 mL round-bottom flask, while removing unreacted magnesium bars, and evacuating to remove THF. First add...
Embodiment 3
[0025] In a 250mL four-necked flask equipped with a thermometer, add 100ml of tetrahydrofuran, then add 10.0g of glucose-2-methacrylamide and 0.2g of dimethylbenzyl dithiobenzoate, under the protection of nitrogen, add the initiator 0.05g of azobisisobutyronitrile AIBN, reacted for 2h in a 70℃ water bath, and TLC was used to detect the completion of the polymerization of the glycosyl monomer; then 10.0g of the comonomer AMPS was added, and the polymerization reaction was continued at 70℃ for 5h. Precipitating with methanol and drying to obtain 12.3 g of "Glucosamine Glycosyl-AMPS" block structure anionic electric field sensitive sugar-based hydrogel.
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