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Children's four-vitamin calcium gluconate effervescent tablets and preparation method thereof

A technology of four-dimensional calcium calcium and effervescent tablets, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of incomplete dissolution, easy precipitation, and poor taste of four-dimensional calcium granules. To achieve the effect of easy quality control, completely reasonable production process and fast drug release speed

Active Publication Date: 2014-01-01
FUZHOU NEPTUNUS FUYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of children's four-dimensional calcium glucose effervescent tablet and its preparation method, which overcomes the problems of conventional children's four-dimensional calcium glucose granules, such as poor taste, often incomplete dissolution, and easy precipitation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Vitamin B 1 0.4g, vitamin B 2 0.2g, vitamin C 5g, vitamin D 2 140,000 units (calculated at 40,000 units / mg), calcium gluconate 300g, glucose 300g, sodium bicarbonate 639.41g, citric acid 468.81g, carboxymethyl starch sodium 88.15g, lactose 316.68g, cross-linked polyethylene pyrrole Alkanone 97.44g, polyethylene glycol 6000 104.75g, micropowder silica gel 73.08g, aspartame 7.31g, orange flavor 31.67g. (vitamin B1, vitamin B2, vitamin C, vitamin D2, calcium gluconate in the formula , glucose raw materials should meet the standards of the Chinese Pharmacopoeia 2010 edition, and are commercially available products; while sodium bicarbonate, citric acid, sodium carboxymethyl starch, lactose, cross-linked polyvinylpyrrolidone, polyethylene glycol 6000, micropowder silica gel , aspartame, and orange flavor essence are pharmaceutical excipients or food additives, and are also commercially available products. Other embodiments are the same as in Example 1).

[0032] The pr...

Embodiment 2

[0039] Vitamin B 1 0.4g, vitamin B 2 0.2g, vitamin C 5g, vitamin D 2 140,000 units (calculated at 40,000 units / mg), calcium gluconate 300g, glucose 300g, sodium bicarbonate 794.86g, citric acid 642.59g, carboxymethyl starch sodium 137.05g, lactose 487.28g, cross-linked polyethylene pyrrole Alkanone 106.60g, polyethylene glycol 6000 91.37g, micronized silica gel 97.46g, aspartame 18.27g, orange flavor 60.91g.

[0040] The preparation process comprises the following steps:

[0041] With embodiment 1 step. Compressed into 1000 tablets by the annular tablet mold of tablet press, each 3g, outer diameter 25mm, inner diameter 6mm annular effervescent tablet. (The relative humidity during production is controlled at 40%, and the temperature is 15-25°C).

Embodiment 3

[0043] Vitamin B 1 0.4g, vitamin B 2 0.2g, vitamin C 5g, vitamin D 2 140,000 units (calculated at 40,000 units / mg), calcium gluconate 300g, glucose 300g, sodium bicarbonate 335.01g, citric acid 304.55g, carboxymethyl starch sodium 30.46g, lactose 144.48g, cross-linked polyethylene pyrrole Alkanone 30.46g, polyethylene glycol 6000 30.46g, micropowder silica gel 27.41g, aspartame 1.5g, orange flavor 9.30g.

[0044] The preparation process comprises the following steps:

[0045] 1) Same as step 1 of embodiment 1.

[0046] 2) Same as step 2 of embodiment 1.

[0047] 3) Step 3 with embodiment 1.

[0048] 4) Dissolve polyethylene glycol 6000 in ethanol, then dissolve sodium bicarbonate in it, spray dry, sieve and granulate for later use.

[0049] 5) Same as step 5 of Example 1. Press the annular tablet mold of the tablet press to form 1000 tablets, each 1.5g, annular effervescent tablet with an outer diameter of 20mm and an inner diameter of 8mm. (The relative humidity dur...

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Abstract

The invention discloses children's four-vitamin calcium gluconate effervescent tablets and a preparation method thereof. According to the effervescent tablets, vitamin B1, vitamin B2, vitamin C, vitamin D2, calcium gluconate and glucose are taken as raw materials, and total effervescent tablets containing 1000 tablets comprise the following raw materials: 0.4 g of vitamin B1, 0.2 g of vitamin B2, 5 g of vitamin C, 140 thousand units of vitamin D2 calculated according to 40 thousand units / mg, 300 g of calcium gluconate, 300 g of glucose, and 80%-60% by weight of auxiliary materials accounting for the total tablets. The children's four-vitamin calcium gluconate effervescent tablets are prepared by a special technology, and are good medicine for supplementing vitamins and calcium in children bodies as a vitamin and calcium supplement medicine; and the children's four-vitamin calcium gluconate effervescent tablets have the characteristics of being high in bioavailability, good in mouthfeel, convenient to use, easily accepted by children, convenient to carry and the like. Because of the auxiliary materials and the annular effervescent tablets, the children's four-vitamin calcium gluconate effervescent tablets can be rapidly disintegrated.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and relates to the preparation of prescriptions for children's Siwei Calcium Glucose Effervescent Tablets. Background technique [0002] Rickets is what we often call "calcium deficiency" in infants and young children. Even though the current living standards have improved a lot, the incidence of rickets is still very high. According to reports, in the south, the rate of rickets in infants under 1 year old is 20-30%, and it is higher in the north (20-45%, which is closely related to the sunshine time). Rickets is more common in infancy. It is a disease in which calcium and phosphorus metabolism disorders in the body are caused by vitamin D deficiency, resulting in poor bone calcification. The onset of rickets is slow, and it is not easy to attract attention. Rickets lowers children's resistance, and it is easy to be combined with diseases such as pneumonia and diarrhea, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/592A61K31/51A61K31/525A61K31/375A61K31/191A61K9/46A61P3/14A61P3/02
Inventor 俞宁
Owner FUZHOU NEPTUNUS FUYAO PHARMA
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