Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for continuous production of 5'-nucleotide by using micro-channel reaction device

A technology of microchannel reaction and nucleotide, which is applied in the field of chemical synthesis and technology, can solve the problems of large amount of phosphorus oxyhalide, long production cycle, and environmental pollution, and achieve short reaction time, simple operation, and high conversion rate. Effect

Active Publication Date: 2014-01-01
NANJING UNIV OF TECH
View PDF4 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the problems referred to above, the technical problem to be solved by the present invention is to provide a new method for continuously producing 5'-nucleotides with a microchannel reaction device, so as to overcome the defects of traditional reactors and the long production cycle in the prior art. Problems such as large amount of phosphorus oxyhalide, high energy consumption, and environmental pollution

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for continuous production of 5'-nucleotide by using micro-channel reaction device
  • Method for continuous production of 5'-nucleotide by using micro-channel reaction device
  • Method for continuous production of 5'-nucleotide by using micro-channel reaction device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The uridine trimethyl phosphate solution (first raw material storage tank) and phosphorus oxychloride (second raw material storage tank) with a mass ratio of uridine and trimethyl phosphate of 1:5 are 1:4 (volume The flow rate ratio is 3:1) respectively into the first microstructure mixer and into the first microstructure reactor, and stay in the microstructure reactor at normal temperature and pressure for 25 minutes for reaction. At the same time, ice water (the third raw material storage tank) is injected into the second microstructure reactor respectively through another constant flow pump and the effluent of the first microstructure reactor, wherein the mol ratio of the effluent to ice water is 1:6 (volume flow rate ratio is 1:1), and stay in the second microstructure reactor for 10 minutes at 5°C under normal pressure for reaction, and the second microstructure reactor injects the feed liquid into the product through a long polytetrafluorocapillary tube Storage ta...

Embodiment 2

[0038] Uridine and trimethyl phosphate mass ratio of 1:5 uridine trimethyl phosphate solution (the first raw material storage tank) and phosphorus oxychloride (second raw material storage tank) according to the molar ratio of 1:3 (flow rate The ratio is 4:1) into the first microstructure mixer and into the first microstructure reactor, and stay in the microstructure reactor at normal temperature and pressure for 40 minutes to react. At the same time, ice water (the third raw material storage tank) is injected into the second microstructure reactor respectively through another constant flow pump and the effluent of the first microstructure reactor, wherein the mol ratio of the effluent to ice water is 1:6 (flow rate ratio is 1:1), and stay in the second microstructure reactor at 5°C under normal pressure for 10min to react, the second microstructure reactor injects the feed liquid into the product through a long polytetrafluorocapillary tube Storage tanks, product storage tanks...

Embodiment 3

[0040] Uridine trimethyl phosphate solution (the first raw material storage tank) and phosphorus oxychloride (second raw material storage tank) with a mass ratio of uridine to trimethyl phosphate of 1:5 are 1:5 in molar ratio (flow rate The ratio is 2.5:1) respectively injected into the first microstructure mixer and into the first microstructure reactor, and stayed in the microstructure reactor at normal temperature and pressure for 20 minutes for reaction. At the same time, ice water (the third raw material storage tank) is injected into the second microstructure reactor respectively through another constant flow pump and the effluent of the first microstructure reactor, wherein the mol ratio of the effluent to ice water is 1:6 (the flow rate ratio is 1:1), and stay in the second microstructure reactor at 5°C under normal pressure for 10min to react. The second microstructure reactor injects the feed liquid into the product storage through a long polytetrafluorocapillary tube...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for continuous production of 5'-nucleotide by using a micro-channel reaction device, The method comprises the following steps: dissolving nucleoside in a solvent, according to the volume flow rate of (2-6): 1, pumping the solution and phosphorus oxychloride into a first-stage microstructural reactor of the micro-channel reaction device, keeping 20 to 60 minutes at the temperature of minus 5-25 DEG C, according to the volume flow rate of (1-5): 1, pumping ice water and the discharged material of the first-stage microstructural reactor to a second-stage microstructural reactor, keeping 10-40 minutes at the temperature of 0-5 DEG C, leading the discharged material of the second-stage microstructural reactor to a crystallization kettle, adding ethyl alcohol or acetone for devitrification, so as to obtain coarse 5'-nucleotide, and obtaining the 5'-nucleotide product through refining. According to the invention, the product conversion rate is 90-95%, the product yield is as high as 85-92%, and the product purity (detected through high performance liquid chromatography) is more than 99.5%.

Description

technical field [0001] The invention relates to a new method for continuously producing 5'-nucleotides with a microchannel reaction device, belonging to the field of chemical synthesis and technology. Background technique [0002] As important intermediates of nucleoside drugs, health food and biochemical reagents, 5′-nucleotides are widely used in agriculture, food and pharmaceutical industries. Especially in the application of baby food and medicine, it has an irreplaceable function. In baby food, as an additive in baby food, it can significantly improve the baby's immunity, promote the maturity of the intestinal tract, promote the synthesis of lipoproteins and polyunsaturated fatty acids, reduce the occurrence of colds and diarrhea in babies, and benefit the baby's health. Normal growth and development. In the field of medicine, clinical experiments have shown that 5′-nucleotides participate in human metabolism, promote the improvement and recovery of internal organs, i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07H19/10C07H1/00
Inventor 应汉杰朱晨杰唐成伦郭凯何伟
Owner NANJING UNIV OF TECH