Autofluorescence bone repairing magnetic sustained-release microspheres

A slow-release microsphere and autofluorescence technology, which is applied in the field of bone filling material manufacturing, can solve the problems of high cytotoxicity of cross-linking agents and affect normal tissue growth, etc., and achieves superior biocompatibility, no toxic side effects, and simple preparation method. Effect
CN103495209BInactive Publication Date: 2015-03-04FUZHOU UNIV
3 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2015-03-04
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a self-fluorescent bone repair magnetic slow-release microsphere and a preparation method thereof. The nano-Fe3O4 is synthesized by a solvothermal method, and the nano-Fe3O4 is uniformly dispersed in a sodium alginate solution, and the composite has the functions of promoting proliferation and promoting osteoblasts. Differentiation of traditional Chinese medicine - icariin; the mixture is passed through a microcapsule forming device and dropped into a gel bath to form primary microspheres; then the primary microspheres are immersed in chitosan solution, and chitosan and alginic acid are used to The charge complementary properties of sodium form a polyelectrolyte semipermeable membrane, and the composite microspheres are cross-linked with genipin to prepare autofluorescent magnetic sustained-release microspheres for bone repair. The present invention fully considers the requirement of cytotoxicity as an implantable bone repair material, selects chitosan and sodium alginate with excellent biocompatibility and degradability as raw materials, and can be adjusted according to the needs of bone lesions. Different voltages are used to prepare microspheres with different particle sizes.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of bone filling material manufacture, and in particular relates to autofluorescent bone repair magnetic slow-release microspheres and a preparation method thereof. Background technique

[0002] Trauma, bone tissue inflammation, bone defects caused by congenital defects, and bone tissue diseases such as bone cancer are very common in orthopedic clinics. Relying solely on the self-repair ability of bone is relatively limited. Bone transplantation is often used clinically to treat bone tissue diseases. Therefore, the research and development of bone repair materials is of great significance. In recent years, more and more attention has been paid to the research of microspheres and microcapsules in the field of biomedicine. Microsphere is a kind of spherical or quasi-spherical particle made of suitable polymer material as the carrier. The particle size is generally 1-500 μm, the small one can be several nanometers, and t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More