Verapamil hydrochloride sustained release microsphere and preparation method thereof

A technology of verapamil hydrochloride and sustained-release microspheres, which is applied in the directions of pharmaceutical formulations, medical preparations of inactive ingredients, and pill delivery, etc. Unique, increase the ability to control drug release, improve drug distribution uniformity and particle size uniformity effect
CN103520115AInactive Publication Date: 2014-01-22INNER MONGOLIA MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INNER MONGOLIA MEDICAL UNIV
Publication Date
2014-01-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of a verapamil hydrochloride sustained release microsphere. The preparation method mainly comprises the three major steps of preparation of raw materials, preparation of microsphere forming auxiliary materials and preparation of a sustained release microsphere. A low-temperature spray drying method is adopted, so that the characteristics of a drug are not damaged, the preparation can be completed in one step, the operation is convenient, fast and economical, and the method is suitable for large-scale industrial production. The invention further relates to the verapamil hydrochloride sustained release microsphere prepared with the method.
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Description

technical field

[0001] The invention relates to the field of preparation of pharmaceutical preparations, in particular to the preparation of verapamil hydrochloride sustained-release microsphere preparations Background technique

[0002] Hypertension is one of the most common cardiovascular diseases, and it is also one of the important causes of death and disability in humans. Effective treatment of hypertension can significantly reduce the incidence of cardiovascular events, complications and mortality. At home and abroad, high blood pressure is the first risk factor leading to death. It is estimated that by 2025, the prevalence of hypertension in the world will reach 29%, which means that there will be 1.5 billion hypertensive patients in the world, which is a terrible figure. When the cause of high blood pressure is still unclear, prevention becomes ineffective, and treatment becomes the only effective means. Currently commonly used clinical antihypertensive drugs are:...

Claims

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