Preparation method of compound salvia tablets

Abstract

The invention discloses a preparation method of compound salvia tablets. The preparation method is characterized by comprising the following process steps: (1) putting 450g of salvia into an extraction tank, adding 95% ethanol of which the weight is 4-6 times that of the salvia for soaking for 4-6 hours, performing continuous countercurrent extraction for 1-1.5 hours, filtering the extracting solution, recovering the ethanol from the filtrate, and concentrating the ethanol to an appropriate amount for later use; adding 50% ethanol of which the weight is 3-5 times that of dregs of a decoction into the dregs, performing continuous countercurrent extraction for 1-1.5 hours, filtering the extracting solution, recovering the ethanol from the filtrate, and performing vacuum concentration on the ethanol to an appropriate amount for later use; adding water of which the weight is 3-5 times that of dregs of the decoction into the dregs, performing countercurrent extraction for 1-1.5 hours, filtering the extracting solution, recovering the ethanol from the filtrate, and performing vacuum concentration on the ethanol to an appropriate amount for later use; (2) mixing 141g of notoginseng ultrafine micropowder with a concentrated solution prepared in the step 3, adding an appropriate amount of an auxiliary material, pelletizing through a pelletizing machine, and drying for later use, wherein the percentage is mass percentage; (3) uniformly mixing 8g of borneol ultrafine micropowder with the particles prepared in the step 4, tabletting and coating sugarcoats or film-coats to obtain the compound salvia tablets. The preparation method disclosed by the invention can ensure that active ingredients of the salvia can be extracted out to the utmost extent, and the notoginseng and borneol can give play to drug effects more quickly.

Description

technical field [0001] The invention relates to a new technology of traditional Chinese medicine pharmacy, in particular to a preparation method of compound salvia miltiorrhiza tablets. Background technique [0002] Compound Danshen Tablets is a variety recorded in the Chinese Pharmacopoeia, which has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is used for chest obstruction caused by qi stagnation and blood stasis, symptoms include chest tightness and precordial tingling; coronary heart disease angina pectoris sees the above syndromes. It is a commonly used drug in clinical practice. Salvia miltiorrhiza contains two groups of effective substances: water-soluble components and fat-soluble components. Soluble ingredients include tanshinones, among which tanshinone ⅡA is the main active ingredient for cardiovascular treatment. Therefore, when extracting Danshen, both water-soluble and fat-soluble ingredients must ...

AI Technical Summary

Problems solved by technology

[0004] Although the above-mentioned process can preserve most of the active ingredients, it also has certain disadvantages: due to the limitations of the heating and reflux extraction process itself, the fat-soluble and water-soluble components of Salvia miltiorrhiza cannot be extracted to the greatest extent; When used as medicine, the active ingredient takes a long time to absorb, which is not conducive to exerting the drug effect; the borneol increases the contact time with the air while grinding finely, which increases the risk of borneol being oxidized into camphor in the air, and the coarser particle size of the ground powder is also Not conducive to human absorption

Moreover, the production cycle of this production process is long, the process is complicated, and the production cost is high.

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