Preparation method for magnetic multiple-template steroid estrogen molecular imprinting nanospheres

A technology of magnetic nanospheres and molecular imprinting, applied in chemical instruments and methods, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve the problems of simultaneous removal and detection, singleness, etc., and achieve good water solubility, Simple preparation and rapid separation

Active Publication Date: 2014-01-22
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Most of the currently synthesized steroid estrogen-MIPs use a single template molecule. When multiple ste

Method used

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  • Preparation method for magnetic multiple-template steroid estrogen molecular imprinting nanospheres
  • Preparation method for magnetic multiple-template steroid estrogen molecular imprinting nanospheres
  • Preparation method for magnetic multiple-template steroid estrogen molecular imprinting nanospheres

Examples

Experimental program
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Embodiment 1

[0025] This embodiment includes the following steps:

[0026] Step 1. Put 0.54g of ferric chloride, 1.9g of sodium acetate and 20mL of ethylene glycol in a reaction kettle, react at 200°C for 10h, wash with ultrapure water until neutral, and dry in vacuum. instant figure 1 Magnetic nanospheres with a particle size of about 200nm;

[0027] Step 2: Take 50 mg of magnetic nanospheres from Step 1, then put 30 mL of ethanol, 15 mL of ultrapure water, 1 mL of ammonia water and 1 mL of tetraethoxysilane TEOS into a three-necked flask, react at room temperature for 10 hours, wash with ultrapure water until neutral, Vacuum drying, making the surface of the magnetic nanosphere coated with a silicon layer with a thickness of 18-22nm; figure 2 The particle size is about 220nm and silicon-coated magnetic nanospheres;

[0028] Step 3, adding the functional monomer and three steroid estrogens to 20mL of ethanol to obtain a multi-template-functional monomer complex;

[0029] The function...

Embodiment 2

[0045] This embodiment includes the following steps:

[0046] Step 1. Put 0.54g of ferric chloride, 1.9g of sodium acetate and 20mL of ethylene glycol in a reaction kettle, react at 200°C for 10h, wash with ultrapure water until neutral, and dry in vacuum. instant figure 1 Magnetic nanospheres with a particle size of about 200nm;

[0047] Step 2: Take 50 mg of magnetic nanospheres from Step 1, then put 30 mL of ethanol, 15 mL of ultrapure water, 1 mL of ammonia water and 1 mL of tetraethoxysilane TEOS into a three-necked flask, react at room temperature for 10 hours, wash with ultrapure water until neutral, Vacuum drying, making the surface of the magnetic nanosphere coated with a silicon layer with a thickness of 18-22nm; figure 2 The particle size is about 220nm and silicon-coated magnetic nanospheres;

[0048] Step 3, adding the functional monomer and three steroid estrogens to 20mL of ethanol to obtain a multi-template-functional monomer complex;

[0049] The function...

Embodiment 3

[0066] This embodiment includes the following steps:

[0067] Step 1. Put 0.54g of ferric chloride, 1.9g of sodium acetate and 20mL of ethylene glycol in a reaction kettle, react at 200°C for 10h, wash with ultrapure water until neutral, and dry in vacuum. instant figure 1 Magnetic nanospheres with a particle size of about 200nm;

[0068] Step 2: Take 50 mg of magnetic nanospheres from Step 1, then put 30 mL of ethanol, 15 mL of ultrapure water, 1 mL of ammonia water and 1 mL of tetraethoxysilane TEOS into a three-necked flask, react at room temperature for 10 hours, wash with ultrapure water until neutral, Vacuum drying, making the surface of the magnetic nanosphere coated with a silicon layer with a thickness of 18-22nm; figure 2 The particle size is about 220nm and silicon-coated magnetic nanospheres;

[0069] Step 3, adding the functional monomer and three steroid estrogens to 20mL of ethanol to obtain a multi-template-functional monomer complex;

[0070] The function...

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Abstract

The invention relates to a preparation method for magnetic multiple-template steroid estrogen molecular imprinting nanospheres. The method includes synthesizing magnetic nanospheres having a particle size of about 200 nm through a hydrothermal method; coating a silicon coating on the magnetic nanospheres through a sol-gel method; adding functional monomers, three steroid estrogens into ethanol to obtain a multiple templates/functional monomer composite; adding silicon-coated magnetic nanospheres and a catalyst into the multiple templates/functional monomer composite to perform polymerization; separating a solid polymer through an additional magnetic field; and eluting the solid polymer and drying to obtain the magnetic multiple-template steroid estrogen molecular imprinting nanospheres. According to the preparation method, specific identification of molecular imprinting and easy separability of the magnetic nanospheres are combined. The preparation method is simple and conditions are mild. The polymer prepared is uniform in particle size, strong in stability, and good in water solubility, and can achieve rapid high-selectivity removal and enrichment of the three steroid estrogens in trace amount in the environment and drinking water samples.

Description

technical field [0001] The invention relates to the technical fields of molecular recognition, magnetic separation, nanometer materials and environmental chemistry, and in particular to a preparation method of magnetic multi-template steroid estrogen molecularly imprinted nanospheres. Background technique [0002] With the continuous improvement of people's living standards, the use of cosmetics, contraceptives, and hormone supplements has increased dramatically, and the amount of steroid estrogens (Steroid Estrogens, SEs) entering production and domestic sewage has also increased significantly. The concentration of total estrogen in environmental water samples higher than 1ng / L will make some wild male fish feminized, and the concentration of estrogen enriched in organisms through the food chain is much greater than the concentration left in the environment. By eating these polluted fish, humans will accumulate excess estrogen in the body, leading to adverse symptoms such a...

Claims

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Application Information

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IPC IPC(8): C08G77/26C08K9/10C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 高瑞霞郝旖张军杰唐玉海
Owner XI AN JIAOTONG UNIV
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