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Preparation method of medicine used for controlling pasteurella infection of livestock and poultry

A formula, compound sulfonamide technology, applied in the directions of antibacterial drugs, drug combinations, pharmaceutical formulas, etc., can solve the problem of not preventing and controlling Pasteurella infection of livestock and poultry, achieve health care prevention and treatment safety, easy to mix evenly, easy to pour Effect

Inactive Publication Date: 2015-05-13
四川联美生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneously, there is no sulfachlordazine sodium powder preparation for preventing and treating Pasteurella infection in livestock and poultry in the prior art

Method used

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  • Preparation method of medicine used for controlling pasteurella infection of livestock and poultry
  • Preparation method of medicine used for controlling pasteurella infection of livestock and poultry
  • Preparation method of medicine used for controlling pasteurella infection of livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Formula

[0026] Sulfachlordazine sodium 60g, indomethacin potassium 2g, bentonite 5g, sodium citrate 5g, sodium carboxymethylcellulose 3g, sodium saccharin 2g, soluble starch 23g.

[0027] 2: Preparation method

[0028] The first step: take the bentonite, sodium citrate, and sodium carboxymethylcellulose of the prescription amount and grind them, pass through an 80-mesh sieve after grinding, and then stir and mix for 15 minutes to obtain A powder without patterns and stains;

[0029] The second step: take the prescribed amount of sulfachlordazine sodium, indomethacin potassium and saccharin sodium and pulverize, pass through an 80-mesh sieve after pulverization, and then stir and mix for 15 minutes to obtain B powder without patterns and spots;

[0030] Step 3: Add the above-mentioned B powder to the A powder according to the method of equal addition and stir evenly, then add enough soluble starch and continue to stir and mix for 15 minutes. After checking and con...

Embodiment 2

[0032] 1. Formula

[0033] Sulfachlordazine sodium 62.5g, indomethacin potassium 3g, bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethylcellulose 4g, sucrose 3g, anhydrous glucose 12.5g.

[0034] 2: Preparation method: the same as the method described in Example 1, only the corrective agent sodium saccharin is replaced with sucrose, and other carrier soluble starch is replaced with anhydrous glucose.

Embodiment 3

[0036] 1. Formula

[0037] Sulfachlordazine sodium 65g, indomethacin potassium 4g, bentonite 10g, sodium citrate 10g, sodium carboxymethylcellulose 5g, sucrose 4g, anhydrous glucose 2g.

[0038] 2: Preparation method: the same as the method described in Example 1, only the corrective agent sodium saccharin is replaced with sucrose, and other carrier soluble starch is replaced with anhydrous glucose.

[0039] Stability test of compound sulfachlorperazine sodium powder

[0040] 1. Materials and methods: get the compound sulfachlordazine sodium powder of embodiment 1-3, carry out high-temperature, high-humidity, and strong-light acceleration experiments according to the drug stability test method of the first appendix of "Chinese Veterinary Pharmacopoeia" 2010 edition, and pack according to commercially available , placed in a drug stability test box (Chongqing Yongsheng Experimental Instrument Factory) with a temperature of 40±2°C, a relative humidity of 75±5%, and an illuminat...

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PUM

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Abstract

The invention relates to compound sulfachlorpyridazine sodium powder, and specifically provides a preparation method of compound sulfachlorpyridazine sodium powder used for controlling pasteurella infection of livestock and poultry. 100 parts of the compound sulfachlorpyridazine sodium powder comprise 60 to 65 parts of sulfachlorpyridazine sodium, 2 to 4 parts of indometacin potassium, 10 to 25 parts of a suspending agent, 2 to 4 parts of a corrigent and the balance an acceptable carrier. The ingredients above are mixed and grinded so as to obtain the compound sulfachlorpyridazine sodium powder. The compound sulfachlorpyridazine sodium powder possesses accurate curative effects on pasteurellosis of a plurality of animals, and is suitable for popularization and application in livestock breeding. According to the preparation method, sulfachlorpyridazine sodium and indometacin potassium are used together, besides antisepsis and anti-inflammation effects, indometacin potassium is used as an antibacterial synergist of sulfachlorpyridazine sodium, so that synergistic effect is achieved, and pharmacological function of the main medicine is improved. Absorptivity of the compound sulfachlorpyridazine sodium powder, which can be taken orally, or mixed with feed for use, or dissolved in drinking water for use, is high; drug tolerance is difficult to be caused; the compound sulfachlorpyridazine sodium powder is safe to be used for protection, prevention and therapy in a long term. Palatability, fluidity and suspending water solubility are excellent; clinical administration methods are diverse; and the compound sulfachlorpyridazine sodium powder is convenient for clinical administration.

Description

[0001] This application is a divisional application of the invention patent with the application number: 201210358062.0 and the patent name: "A method for preparing compound sulfachlordazine sodium powder". The original application date: September 24, 2012. technical field [0002] The invention relates to a compound sulfachlordazine sodium powder, and also relates to a medicine for preventing and treating Pasteurella infection in livestock and poultry. Background technique [0003] The antibacterial spectrum of sulfachlordazine sodium is similar to that of sulfamethoxine. It is one of the sulfa drugs with the strongest antibacterial effect in the body. It has a strong inhibitory effect on most Gram-positive and negative bacteria. Resistance is slower. The blood concentration is high, the acetylation rate is low, and it is not easy to produce crystalluria. [0004] Pasteurellosis is a septic infectious disease of various animals caused by Pasteurella multocida. When factor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/14A61P31/04A61P29/00A61K31/405
Inventor 秦斌陈益德胡学全
Owner 四川联美生物药业有限公司
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