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Preparation method of calcium metaphosphate porous bioceramic

A technology of calcium metaphosphate and bioceramics, which is applied in the field of preparation of calcium metaphosphate porous bioceramics, and can solve the problem that the porous ceramics method has not been reported.

Inactive Publication Date: 2014-01-29
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But above-mentioned method has not reported to the method for preparing porous ceramics by in-situ method

Method used

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  • Preparation method of calcium metaphosphate porous bioceramic
  • Preparation method of calcium metaphosphate porous bioceramic
  • Preparation method of calcium metaphosphate porous bioceramic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Step 1: Ca(H 2 PO 4 ) 2 ·H 2 Preparation of O(MCPM) precursor

[0033] Add 42.06 g of calcium oxide with a Ca / P mol ratio of 0.5 to 500.0 ml of a phosphoric acid solution with a concentration of 3.0 mol. After stirring the solution for 48 hours with a magnetic stirrer, put the beaker into an electric constant temperature blast drying oven at 60°C Drying under high temperature for 7 days, ball milling the dried powder, passing through a 200-mesh sieve. That is, Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) precursor powder. Product Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) powder X-ray diffraction pattern as attached to the instruction manual figure 1 shown.

[0034] Step 2: Preparation of calcium metaphosphate porous ceramics

[0035] Take 5.0g of synthesized Ca(H 2 PO 4 ) 2 ·H 2 After mixing O(MCPM) and 5.0wt% PVA binder evenly, granulate and sieve, use dry pressing method to form at 2.0MPa, then heat up to 500°C at 0.5°C / min, and then press 5.0°C / min The heating rate of min wa...

Embodiment 2

[0037] Step 1: Ca(H 2 PO 4 ) 2 ·H 2 Preparation of O(MCPM) precursor

[0038] Add 14.02 g of calcium oxide with a Ca / P mol ratio of 0.5 to 500.0 ml of a phosphoric acid solution with a concentration of 1.0 mol. After stirring the solution for 48 hours with a magnetic stirrer, put the beaker into an electric constant temperature blast drying oven at 60°C Drying under high temperature for 7 days, ball milling the dried powder, passing through a 200-mesh sieve. That is, Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) precursor powder. Product Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) powder X-ray diffraction pattern as attached to the instruction manual figure 1 shown.

[0039] Step 2: Preparation of calcium metaphosphate porous ceramics

[0040] Take 5.0g of synthesized Ca(H 2 PO 4 ) 2 ·H 2 Ca(H 2 PO 4 ) 2 (MCPA). Then Ca(H 2 PO 4 ) 2 (MCPA) mixed with 5.0wt% PVA binder evenly, granulated and sieved, formed by dry pressing at 2.0MPa, then heated at 0.5°C / min to 500°C, and then presse...

Embodiment 3

[0042] Step 1: Ca(H 2 PO 4 ) 2 ·H 2 Preparation of O(MCPM) precursor

[0043] Add 28.04g of calcium oxide with a Ca / P mol ratio of 0.5 to 500.0ml of a phosphoric acid solution with a concentration of 2.0mol. After stirring the solution for 48 hours with a magnetic stirrer, put the beaker into an electric constant temperature blast drying oven at 60°C Drying under high temperature for 7 days, ball milling the dried powder, passing through a 200-mesh sieve. That is, Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) precursor powder. Product Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) powder X-ray diffraction pattern as attached to the instruction manual figure 1 shown.

[0044] Step 2: Preparation of calcium metaphosphate porous ceramics

[0045] Take 5.0g of synthesized Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) was heat-treated at 250 °C for 0.5 h to produce CaH 2 P 2 o 7 (CDPP). CaH 2 P 2 o 7 (CDPP) mixed with 5.0wt% PVA binder evenly, granulated and sieved, formed by dry pressing at 40.0MPa, then ...

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Abstract

The invention relates to a preparation method of calcium metaphosphate porous bioceramic. The preparation method is characterized by using calcium oxide and phosphoric acid as initial reactants to synthesize monocalcium phosphate monohydrate (Ca(H2PO4)2.H2O, MCPM) powder by means of isothermal crystallization chemical precipitation according to the formation mechanism of calcium metaphosphate; carrying out thermal treatment on the powder at different temperatures respectively to synthesize monocalcium phosphate (Ca(H2PO4)2, MCPA) powder and calcium dihydrogen pyrophosphate (CaH2P2O7, CDPP) powder; preparing the calcium metaphosphate porous ceramic from the powder synthesized respectively in the condition of controlling the molding process and the sintering mechanism (such as the molding pressure of the sample, and the temperature raising rate of the initial thermal treatment). The gas released when different crystal water contained in the raw material is decomposed is used as a pore forming agent, and the synthesis method of the powder and the preparation process of the porous body are controlled to obtain the calcium metaphosphate porous ceramic prepared by adopting the preparation method disclosed by the invention.

Description

technical field [0001] The invention relates to a preparation method of calcium metaphosphate porous bioceramics. technical background [0002] At present, biomaterials mainly include three types: medical metal materials, ceramic materials and medical polymer materials. Metal materials have high strength and are easy to process into complex shapes. Common medical metal materials include cobalt-chromium alloys, titanium alloys, and stainless steel. Medical polymer materials are easy to degrade, including naturally derived chitosan, collagen, various proteins and artificially synthesized polylactic acid, polyethylene, polypropylene and other polymers. Ceramic materials have both properties and are often used as orthopedic implants and dental materials. Typical representatives are alumina, calcium phosphate and bioglass. [0003] Calcium metaphosphate (CMP) has the advantages of excellent biocompatibility, bioactivity, biodegradability, osteoconductivity and osteoinductivity,...

Claims

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Application Information

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IPC IPC(8): C04B38/00C04B35/622C04B35/447
Inventor 张垠姚能健
Owner NANJING UNIV OF TECH
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