Double-stimulus response hydrogel with cyclodextrin and preparation method thereof

A dual-stimuli-response, cyclodextrin technology, applied in the direction of non-active components of polymer compounds, can solve the problems of hydrophobic drug molecule loading and effective release, and achieve the effect of easy realization and simple preparation process
CN103554369AActive Publication Date: 2014-02-05JIANGSU UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU UNIV
Publication Date
2014-02-05

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Abstract

The invention discloses a double-stimulus response hydrogel with cyclodextrin and a preparation method thereof. A gel macromolecular chain is provided with a cyclodextrin group, a temperature sensitive unit and a pH value sensitive unit, wherein the weight percentage of the cyclodextrin group contained in a gel macromolecule is 14%-57%; the temperature sensitive unit is isopropyl acrylamide, and the weight percentage of the temperature sensitive unit in the gel macromolecule is 20%-50%; the pH value sensitive unit is acrylic acid, and the weight percentage of the pH value sensitive unit in the gel macromolecule is 14%-57%. According to the invention, the prepared carrier hydrogel can be used for loading of a large quantity of drug molecules by introducing cyclodextrin and the temperature and pH value response structure units; when outside temperature and a pH value are changed, the responsive change of regulating the release speed of drugs can be generated. The preparation process of the provided double-stimulus response carrier hydrogel with the cyclodextrin group is simple and convenient and easy to realize.
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Description

[0001] technical field

[0002] The invention relates to the field of dual-stimuli-responsive intelligent polymer materials, in particular to a dual-stimuli-responsive hydrogel with cyclodextrin and a preparation method thereof. Background technique

[0003] The development of modern medicine and the improvement of people's living standards require drug delivery carriers to deliver drugs to designated sites at a predetermined release rate within a predetermined time, so as to maximize the bioavailability of drug molecules and reduce drug toxicity. purpose of side effects. Hydrogel is one of ideal materials used as this controlled release drug carrier (Pepas N.A., Bures P., Leobandung W., Ichikawa H., Hydrogels in pharmaceutical formulations, European Journal of Pharmaceutics and Biopharmaceutics, 2000, 50: 27 -46). Generally speaking, hydrogel is a three-dimensional network constructed by hydrophilic macromolecular chains, which can be highly swollen in water and retain a ...

Claims

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