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Self-adhesion hemostasis anti-adhesion corpus fibrosum

A fibrous and anti-adhesion technology, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problem of unresolved metabolism of hemostatic agents, etc.

Active Publication Date: 2015-04-22
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our previous studies have shown that the combination of hemostatic agent and anti-adhesion material can effectively prevent the occurrence of postoperative active bleeding, but for the selection of the amount of hemostatic agent, how to better release it for different wounds and the remaining hemostatic agent in the anti-adhesion film after hemostasis is completed The problem of drug metabolism has not been solved

Method used

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  • Self-adhesion hemostasis anti-adhesion corpus fibrosum

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In this embodiment, the anti-adhesion fiber body with self-adhesive and hemostatic function is prepared according to the following method:

[0037] (1) Prepare organic polymer mixed solution: dissolve PLGA (Mw=80,000, LA / GA=75 / 25) in DMF / acetone mixed solvent (DMF / acetone volume ratio 1 / 1), and prepare a concentration of 30 % (W / V) organic polymer mixed solution, stirred at room temperature for 12 hours.

[0038] (2) Preparation of anti-adhesion fiber material: Inject the organic polymer mixed solution prepared in step (1) into ten 10mL syringes respectively, add a No. 5 stainless steel needle, at a voltage of 25KV, and a solution flow rate of 1.5mL / h, Under the condition that the receiving distance is 18 cm, multi-nozzle electrospinning is carried out for 40 minutes to obtain a composite fiber material, which is vacuum-dried at room temperature for 24-48 hours to remove residual solvent, and the thickness of the fiber membrane material is 100-140 microns.

[0039] (3)...

Embodiment 2

[0042] In this embodiment, the anti-adhesion fiber body with self-adhesive and hemostatic function is prepared according to the following method:

[0043] (1) Preparation of organic polymer mixed solution: Dissolve PLA (Mw=50,000) in DMF / acetone mixed solvent (DMF / acetone volume ratio 1 / 1), and prepare an organic polymer solution with a concentration of 20% (W / V). The polymer mixed solution was stirred at room temperature for 8 hours.

[0044] (2) Preparation of anti-adhesion fiber material: Inject the organic polymer mixed solution prepared in step (1) into ten 10mL syringes, add a No. 5 stainless steel needle, and receive Under the condition of a distance of 25 cm, multi-nozzle electrospinning was carried out for 40 minutes to obtain a composite fiber material, which was vacuum-dried at room temperature for 24 hours to remove residual solvent, and the thickness of the fiber membrane material was 100-120 microns.

[0045] (3) Preparation of hemostatic material solution: Diss...

Embodiment 3

[0048] In this embodiment, the anti-adhesion fiber body with self-adhesive and hemostatic function is prepared according to the following method:

[0049] (1) Prepare organic polymer mixed solution: dissolve PGCL (Mw=500,000, CL / GA=75 / 25) in DMF / acetone mixed solvent (DMF / acetone volume ratio 1 / 1), and prepare a concentration of 50 % (W / V) organic polymer mixed solution, stirred at room temperature for 15 hours.

[0050] (2) Preparation of anti-adhesion fiber material: Inject the organic polymer mixed solution prepared in step (1) into ten 10mL syringes respectively, add a No. 5 stainless steel needle, at a voltage of 30KV, and a solution flow rate of 1mL / h, receive Under the condition of a distance of 5 cm, multi-nozzle electrospinning was performed for 60 minutes to obtain a composite fiber material, which was vacuum-dried at room temperature for 48 hours to remove residual solvent, and the thickness of the fiber membrane material was 150-180 microns.

[0051] (3) Preparati...

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Abstract

The invention discloses a self-adhesion hemostasis anti-adhesion corpus fibrosum which comprises organic polymers and carboxymethyl chitosan, wherein the organic polymers are selected from poly(lactic-co-glycolic acid) copolymer, polylactic acid, polylactic acid-polyethylene glycol block copolymer, polycarprolactone-glycolic acid copolymer and polycarprolactone. The self-adhesion hemostasis anti-adhesion corpus fibrosum has enough mechanical strength, can stop bleeding and prevent adhesion, and is suitable for hemostasis anti-adhesion treatment of active hemorrhage.

Description

technical field [0001] The invention relates to the technical field of medical anti-adhesion materials, in particular to a self-adhesive hemostatic anti-adhesion fiber body. Background technique [0002] Postoperative adhesion is one of the important medical problems that have not yet been solved in the field of surgical operations at home and abroad. Adhesions can not only cause serious complications, but poor adhesions are also one of the main reasons for significantly higher complications during reoperation. In order to effectively treat adhesions, the mechanism of adhesions should be clarified first, and the problem should be solved fundamentally. Studies have shown that when tissue is damaged, it will cause cells to release a large amount of histamine and cytokines, which will trigger a local inflammatory response. At the same time, blood vessels leak fibrin, forming a network structure, which in turn causes fibrous tissue and protein deposition. Two possible phenome...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/02A61L31/16A61L15/26A61L15/28A61L15/18A61L15/44
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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