Unlock instant, AI-driven research and patent intelligence for your innovation.

Phloroglucinol film-coated tablet with antioxidative function and preparation method thereof

A technology of film-coated tablets and phloroglucinol, which is applied in the field of medicine, can solve the problems of strict preparation process and instrument requirements, inconvenient packaging, storage and transportation, and relatively expensive commercial prices, and achieves good yield and formability, Ease of self-administration and strong operability

Inactive Publication Date: 2014-03-12
刘宏
View PDF5 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For injection dosage forms such as phloroglucinol injection and powder for injection, they can only be used for injection in medical institutions, which is inconvenient for self-administration and for the elderly or those who are inconvenient to take medicine; Phenol oral preparations—"Phloroglucinol Oral Freeze-dried Tablets" are convenient to use, but in the preparation process, freeze-drying technology and special packaging materials are used to ensure the stability, but the preparation process and equipment requirements Strict, so the production cost is higher, the market price is more expensive, and the hardness is lower, which is not convenient for packaging, storage and transportation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phloroglucinol film-coated tablet with antioxidative function and preparation method thereof
  • Phloroglucinol film-coated tablet with antioxidative function and preparation method thereof
  • Phloroglucinol film-coated tablet with antioxidative function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] One of the preparation of embodiment 1 phloroglucinol film-coated tablet

[0023] Raw materials and ratio:

[0024]

[0025] Specification: 80mg (calculated as phloroglucinol dihydrate)

[0026] Weigh phloroglucinol dihydrate, mannitol, microcrystalline cellulose, and sodium bisulfite in proportioning amounts, crush them separately, pass through an 80-mesh sieve, mix thoroughly, and use 50% ethanol to make a soft material, and granulate After passing through a 20-mesh sieve to make wet granules, dry them at 40°C for 4-5 hours, add lubricant micropowder silica gel to the dry granules, mix them well, and press them into tablets with a tablet machine. (purchased from Colorcon) coating liquid for coating, the coating liquid mass percentage content is 14%, and the film-coated tablet containing phloroglucinol is obtained.

[0027] Measure the plain tablet hardness with a hardness meter, and measure the dissolution rate of the prepared film-coated tablet at 20min accordin...

Embodiment 2

[0030] The second of the preparation of embodiment 2 phloroglucinol film-coated tablets

[0031] Raw materials and ratio:

[0032]

[0033] The preparation method is the same as in Example 1. The concentration of the prepared coating solution is the specification of 14% phloroglucinol film-coated tablet: 80 mg (calculated as phloroglucinol dihydrate).

[0034] Measure the plain tablet hardness with a hardness meter, and measure the dissolution rate of the prepared film-coated tablet at 20min according to the method in the quality inspection item:

[0035] Hardness (N) 12.7±1.0

[0036] 20min dissolution rate (%) 95.48%.

experiment example 3

[0037] The third of the preparation of experimental example 3 phloroglucinol film-coated tablet

[0038] Raw materials and ratio:

[0039]

[0040]

[0041] Preparation of adhesive: Dissolve hydroxypropyl methylcellulose into 50% (volume ratio) ethanol aqueous solution to prepare 10% (g / ml) hypromellose solution as adhesive.

[0042] Preparation method: replace the 50% ethanol soft material in Example 1 with an adhesive, other steps of the preparation method are the same as in Example 1, and the adhesive is to combine the hydroxypropylmethylcellulose in the above raw materials with 50% ethanol aqueous solution (the volume ratio of ethanol to water is 1:1) is a 10% hydroxypropyl methylcellulose solution prepared at a ratio of 1:10 by weight to volume g / ml.

[0043] Measure the plain tablet hardness with a hardness meter, and measure the dissolution rate of the prepared film-coated tablet at 20min according to the method in the quality inspection item:

[0044] Hardness ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention provides a phloroglucinol film-coated tablet with an antioxidative function and a preparation method thereof. Phloroglucinol dihydrate is used as an active ingredient, excipients such as a filling agent, an antioxidant and a lubricating agent are added into the active ingredient, and coating with a water-soluble coating material to prepare the phloroglucinol film-coated tablet. The preparation method comprises the following steps of sieving, mixing, pelletizing, tabletting and coating. The phloroglucinol film-coated tablet can effectively overcome the easy-oxidization performance of phloroglucinol, the labeled amount can be controlled, the tablet weight variation is stable, and the dissolution speed is high. The stability is good after the phloroglucinol is coated, the rate of finished products is high, and the cost is low. The preparation method is simple to operate and easy to master and regulate, and the quality of products is stable and controllable.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a phloroglucinol pharmaceutical preparation, in particular to a phloroglucinol film-coated tablet and a preparation method thereof. Background technique [0002] Phloroglucinol belongs to myotropic non-atropine non-papaverine pure smooth muscle antispasmodics, it can directly act on the smooth muscle of gastrointestinal tract and genitourinary tract, and only acts on spasmodic smooth muscle, and has little effect on normal smooth muscle. Compared with other antispasmodics for smooth muscle, it is characterized by no anticholinergic effect. While relieving smooth muscle spasm, it will not produce a series of anticholinergic side effects, and will not cause symptoms such as hypotension, increased heart rate, and arrhythmia. , had no effect on cardiovascular function. Its toxic and side effects are small, and the drug safety is relatively high. [0003] Phloroglucinol is mainly used clinical...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K9/30A61K47/10A61K47/38A61K47/02A61P1/06A61P13/06A61P15/00
Inventor 刘宏陈丹杨瑞玲符旭东余梦辰廖祥茹陈鹰刘辉
Owner 刘宏