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O-phthalaldehyde disinfectant and preparation method thereof

A technology of phthalaldehyde and disinfectant, which is applied in the direction of disinfectant, botany equipment and method, biocide, etc., can solve the problem that the normal physiological function of bacteria cannot be carried out, the signal of cell nutrient feeding cannot be obtained, and the dysfunction of material exchange, etc. problem, achieve good synergistic sterilization effect, shorten preparation time and save processing time

Inactive Publication Date: 2014-03-19
SHINVA MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sealing and anti-seepage effect of OPA also causes the dysfunction of material exchange inside and outside the bacteria, so that the normal physiological functions of bacteria cannot be carried out, thereby promoting cell death.
[0005] Recent studies have found that OPA-treated buds do not release pyridinecarboxylic acid (DPA), which may be that the receptors of buds to nutrients in the external environment are damaged by OPA, so that the cells cannot receive signals for nutritional feeding, thus weakening The release of DPA

Method used

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  • O-phthalaldehyde disinfectant and preparation method thereof
  • O-phthalaldehyde disinfectant and preparation method thereof
  • O-phthalaldehyde disinfectant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Composed of raw materials in the following weight percentages:

[0034]

[0035] The preparation method is:

[0036] (1) Add alkene-based fatty sulfonic anhydride (ASA) to 20% aqueous potassium hydroxide solution, react at 40°C for 3 hours, take the mixed solution in deionized water, if it can be completely dissolved, it means the reaction is complete, after the reaction is completed That is ASK solution;

[0037] (2) Dissolve o-phthalaldehyde in ethanol, stir to make it completely dissolved until clear; then add deionized water, mix well; then add coupling agent, complexing agent, after complete dissolution, add ASK solution and pH buffer Disinfectants (sodium dihydrogen phosphate and disodium hydrogen phosphate) until they are completely dissolved, and then filled after standing still. By adjusting the ratio of sodium dihydrogen phosphate and disodium hydrogen phosphate, the pH value of the prepared o-phthalaldehyde disinfectant is 8.5.

Embodiment 2

[0039] Consists of the following raw materials in parts by weight:

[0040]

[0041] The preparation method is:

[0042] (1) Add alkene-based fatty sulfonic anhydride (ASA) to triethanolamine, react at 10°C for 4 hours, take its mixed solution in deionized water, if it can be completely dissolved, it means that the reaction is complete, and the ASK solution is obtained after the reaction is completed;

[0043] (2) Dissolve o-phthalaldehyde in ethanol, stir to make it completely dissolved until clear; then add deionized water, mix well; then add coupling agent, complexing agent, after complete dissolution, add ASK solution and pH buffer Disinfectant (sodium dihydrogen phosphate and disodium hydrogen phosphate) until it is completely dissolved, and filled after standing still. By adjusting the ratio of sodium dihydrogen phosphate and disodium hydrogen phosphate, the pH value of the prepared o-phthalaldehyde disinfectant is 9.0.

Embodiment 3

[0045] Consists of the following raw materials in parts by weight:

[0046]

[0047] The preparation method is:

[0048] (1) Add alkenyl fatty sulfonic anhydride (ASA) into 15% potassium hydroxide aqueous solution, react at 45°C for 2 hours, take the mixed solution in deionized water, and if it can be completely dissolved, it means the reaction is complete. Obtain ASK solution;

[0049](2) Dissolve o-phthalaldehyde in ethanol, stir to make it completely dissolved until clear; then add deionized water, mix well; then add coupling agent, complexing agent, after complete dissolution, add ASK solution and pH buffer Disinfectants (sodium dihydrogen phosphate and disodium hydrogen phosphate) until they are completely dissolved, and filled after standing still. By adjusting the ratio of sodium dihydrogen phosphate and disodium hydrogen phosphate, the pH value of the prepared o-phthalaldehyde disinfectant is 7.0.

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Abstract

The invention belongs to the field of chemical disinfection product preparations, and in particular relates to an o-phthalaldehyde disinfectant. The o-phthalaldehyde disinfectant is composed of the following raw materials by weight percent: 0.5-1% of o-phthalaldehyde, 0.5-5% of ASK solution (which is obtained by adding alkylene aliphatic sulfonic anhydride in an alkaline solution to react), 5-20% of short chain alcohol, 0.1-1% of complexing agent, 0.2-2% of pH buffer agent, and the balance of deionized water. By adopting the compound form of the o-phthalaldehyde disinfectant and the alkylene aliphatic sulfonic anhydride, good synergic sterilization effect and no foam are realized, and the spraying and immersion disinfection can be satisfied. The invention further provides a preparation method of the o-phthalaldehyde disinfectant, which comprises the following steps: dissolving the o-phthalaldehyde in ethanol, clearly dissolving, adding the deionized water, uniformly mixing, adding a coupling agent and a complexing agent, and then adding an ASK solution and a pH buffer agent after the coupling agent and complexing agent are dissolved till completely dissolving, standing to obtain the product. The process manufacture is simple and the processing time is effectively saved.

Description

technical field [0001] The invention belongs to the field of chemical disinfection product preparations, and in particular relates to an o-phthalaldehyde disinfectant and a preparation method thereof. Background technique [0002] Ortho-phthalaldehyde (OPA) is an important pharmaceutical and chemical intermediate, which was mainly used in amine alkaloids, fluorometer histamine determination reagents and medical inspection in the past. Since Alaf et al. used it for endoscope disinfection in 1994 and found that it has a good disinfection effect, many studies have been carried out on the disinfection of OPA abroad, and it has been developed into a new type of high-efficiency disinfectant and passed the US FDA certification. . [0003] Compared with the disinfectant glutaraldehyde, o-phthalaldehyde has the advantages of broad-spectrum glutaraldehyde, high efficiency, and low corrosion. It also has its own characteristics such as less irritation and low concentration. In additi...

Claims

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Application Information

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IPC IPC(8): A01N35/04A01N25/30A01P1/00
Inventor 董本生杜秀珍单娜娜
Owner SHINVA MEDICAL INSTR CO LTD
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