Method for preparing nano Ag/polymer antimicrobial film by utilizing irradiation method

A polymer film and polymer technology, applied in the field of nano-biomaterials, achieves high yield, short preparation cycle and controllable process

Inactive Publication Date: 2014-03-26
SICHUAN INST OF ATOMIC ENERGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this, there is no report on the introduction of nano-silver on the surface of the polymer film by radiation grafting, especially the one-step improvement of the hydrophilicity and antibacterial properties of the polymer film by the radiation method, and there is no use of PVP to improve the polymer film. Research on the introduction of nano-silver on the surface of polymer film as a stabilizer

Method used

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  • Method for preparing nano Ag/polymer antimicrobial film by utilizing irradiation method
  • Method for preparing nano Ag/polymer antimicrobial film by utilizing irradiation method
  • Method for preparing nano Ag/polymer antimicrobial film by utilizing irradiation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 10ml of NVP monomer, dissolve it in 5ml of ethanol, add 10ml of 0.1mol / L AgNO3 solution, stir the mixed solution evenly, put the PLA film into the mixed solution, vacuumize and fill with nitrogen for 5 times, seal reaction vessel, 60 Co-γ-ray irradiation 5kGy, take out the PLA film, rinse repeatedly with distilled water, and dry it in vacuum at 37°C to obtain light yellow transparent nano-Ag / PLA antibacterial film. The silver content of the antibacterial film is 1.2wt%, and the water absorption rate is 4.3%.

[0040] Tested according to the light industry standard QB / T 2591-2003 of the People's Republic of China, the antibacterial film is 24 hours against Escherichia coli 10 7 The antibacterial rate of CFU / ml is 99.1%.

Embodiment 2

[0042] Take 15ml of NVP monomer, dissolve it in 5ml of ethanol and water solution (the volume ratio of ethanol and water is 1:1), then add 5ml of 0.4mol / L AgNO3 solution, stir the mixed solution evenly, and put the PLGA membrane Put into the mixed solution, vacuumize, fill with nitrogen and operate repeatedly 5 times, seal the reaction vessel, 60 Co-γ-ray irradiation 1kGy, take out the PLGA film, rinse repeatedly with distilled water, and dry it in vacuum at 37°C to obtain a dark yellow transparent nano-Ag / PLGA antibacterial film. The silver content of the antibacterial film is 0.2wt%, and the water absorption rate is 2.0%.

[0043] Tested according to the light industry standard QB / T 2591-2003 of the People's Republic of China, the antibacterial film is 24 hours against Escherichia coli 10 7 The antibacterial rate of CFU / ml was 97.7%.

Embodiment 3

[0045] Take 10ml of NVP monomer, dissolve it in 5ml of ethanol, then add 10ml of 1.0mol / L AgNO3 solution, stir the mixed solution evenly, put the PU film into the mixed solution, vacuumize and fill with nitrogen for 5 times, seal reaction vessel, 60 Co-γ-rays were irradiated to 20kGy, and the PU film was taken out, rinsed repeatedly with distilled water, and vacuum-dried at 37°C to obtain a gray-black nano-Ag / PU antibacterial film. The silver content of the antibacterial film is 10.0wt%, and the water absorption rate is 15%.

[0046] Tested according to the light industry standard QB / T 2591-2003 of the People's Republic of China, the antibacterial film is 24 hours against Escherichia coli 10 7 The antibacterial rate of CFU / ml is 100%.

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Abstract

The invention discloses a method for preparing nano Ag/polymer antimicrobial film by utilizing <60>Co-gama ray or electronic beam irradiation. The method comprises the steps of: dissolving an NVP (N-vinylpyrrolidone) monomer in one or any two of ethanol, methanol, water and acetone, then adding AgNO3 solution, evenly stirring, putting a polymer film into the mixed solution, vacuumizing, irradiating in a closed reaction container, taking out the polymer film, washing with water and drying to obtain the nano Ag/polymer antimicrobial film. No initiator or reductant needs to be added in the irradiation process, NVP is polymerized on the surface of the polymer when Ag<+> is reduced into nano Ag, the method has the advantages that the technology is simple, the process is controllable, the yield is high, the prepared nano Ag/polymer antimicrobial film has good hydrophilicity and safety, the antimicrobial rate to Escherichia coli 107CFU/ml in 24 hours can reach 97.7%-100%.

Description

technical field [0001] The invention relates to the field of nano-biological materials, in particular to a 60 The invention discloses a method for preparing nano-Ag biomedical polymer antibacterial film by irradiation of Co-γ rays or electron beams. Background technique [0002] Medical materials, especially implant materials, are prone to microbial infection during long-term use. Microorganisms first adhere to the surface of materials, and the formed biofilm can protect microorganisms from antibiotic damage and host immune system clearance, promote their proliferation, and endanger human health. Medical antibacterial materials can effectively reduce the risk of disease in the body by blocking, inhibiting or killing pathogenic microorganisms. A good medical antibacterial material needs to have the following characteristics: (1) The material has obvious antibacterial and antibacterial effects on pathogenic microorganisms, and can maintain antibacterial performance for a lon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18C08L67/04C08L75/04C08L69/00C08L29/04C08K3/08B22F9/24
Inventor 彭朝荣王静霞陈浩陈竹平倪茂君陈屿恒包雯婷刘思阳黄科赵星郭丹
Owner SICHUAN INST OF ATOMIC ENERGY
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