Compound polyethylene glycol electrolyte composition

Abstract

The invention discloses a compound polyethylene glycol electrolyte composition, which comprises the following components in parts by weight: 1 part of polyethylene glycol (4000), 0.01-0.05 part of potassium chloride, 0.03-0.06 part of sodium bicarbonate, 0.02-0.06 part of sodium chloride, and 0.9-1.2 parts of anhydrous sodium sulphate. The dosage form of the compound polyethylene glycol electrolyte composition disclosed by the invention is powder. The preparation method of the compound polyethylene glycol electrolyte composition comprises the following steps of respectively crushing polyethylene glycol 4000, potassium chloride, sodium bicarbonate, sodium chloride and anhydrous sodium sulphate, sieving through a 100-mesh sieve, and drying; weighing potassium chloride and sodium bicarbonate fine powder in prescription amount, uniformly mixing, and carrying out split charging in a packet A; weighing anhydrous sodium sulphate and sodium chloride fine powder in prescription amount, uniformly mixing, and split charging in a packet B; weighing polyethylene glycol 4000 fine powder in prescription amount, and split charging in a packet C; putting spared materials into a mixer to mix, and sampling to detect the content of a midbody; and carrying out split charging after calculating and loading according to the content of the midbody, thereby obtaining the compound polyethylene glycol electrolyte composition after sealing.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a compound polyethylene glycol electrolyte composition. Background technique [0002] With the continuous improvement of people's living standards, the number of intestinal cancer and various intestinal diseases increases, and the number of intestinal operations and colonoscopy examinations is increasing day by day. [0003] Polyethylene Glycol Electrolyte Powder is a new type of non-absorbable isopreciative oral whole intestinal cleansing solution. This product is mainly used for bowel cleansing preparation before surgery; bowel cleansing preparation before colonoscopy, barium enema and other examinations. Intestinal cleansers are widely used clinically, exist in various departments, and are used in large quantities. A clean intestinal tract is an important condition for successful operations, reduced complications, and smooth colonoscopy, X-ray barium enema, CT examination, B-ultrasound ...

AI Technical Summary

Problems solved by technology

[0005] Because the density, particle size, particle size shape, specific surface area, porosity, fluidity, etc. of polyethylene glycol and electrolyte are different, it is difficult to mix polyethylene glycol and electrolyte evenly or the powder particles that have been mixed may be affected by equipment. Vibration and stratification during operation lead to different dosages of the components in the produced polyethylene glycol electrolyte powder small package, and the quality is not controlled. Therefore, the polyethylene glycol electrolyte powder currently on the market is usually composed of A, B Two packs or three packs of A, B, and C. The problems brought by such multi-package powders are (1) because they are divided into multiple small packs, the production and packaging process is cumbersome; (2) due to the large number of packs, the quality is uneven and the quality Uncontrollable, low yield; (3) due to excessive packaging during use, it is troublesome to use and easy to cause waste; (4) due to the poor fluidity of polyethylene glycol and electrolyte powder, users sometimes cannot put all polyethylene glycol Alcohol and electrolytes are poured out, or the user forgets to take part of the medicine due to too much medicine packaging. Therefore, not only is it troublesome to take, but it is also easy to cause the solution to be prepared in strict accordance with the instructions, the loss of medicine components, and the distribution ratio of each component is uneven, which eventually leads to the loss of medicines. There is a deviation in the solubility of the solution when it is made into a solution, and the osmotic pressure ratio of the solution cannot be guaranteed to be 1, and the problem of isotonicity inside and outside the intestinal tract cannot be guaranteed. This will not only affect the cleaning effect, but may also cause serious adverse reactions

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