A kind of gadolinium-doped zinc oxide nanoparticles and preparation method thereof

Abstract

The invention relates to gadolinium doped zinc oxide nanoparticles and a preparation method thereof. The gadolinium doped zinc oxide nanoparticles are characterized in that the gadolinium doped zinc oxide nanoparticles are evenly dispersed nanoparticles with diameter of 2-6 nm; fluorescence spectrum shows that the nanoparticles have excitation wavelength of 320-360 nm and emission wavelength of 500-560 nm; the excitation wavelength and the emission wavelength show redshift with the increase of the doping amount of gadolinium; the fluorescence intensity first increases then decreases with the increase of the doping amount of gadolinium; and when a molar ratio of zinc to gadolinium is at 1:0.08, the fluorescence enhancement reaches the maximum. The product has application prospect in magnetic resonance and fluorescence double functional imaging. The invention has the advantages that a cheap zinc material with good biocompatibility is employed for direct synthesis of gadolinium doped zinc oxide nanoparticles through a sol-gel method, the method on the one hand reduces the toxicity of the final product, and on the other hand reduces the cost of the product, and the product has application prospect in magnetic resonance and fluorescence double functional imaging.

Description

technical field [0001] The invention relates to a zinc oxide nanoparticle and a preparation method thereof, in particular to a gadolinium-doped zinc oxide nanoparticle and a preparation method thereof. Background technique [0002] With the needs of biomedical research and diagnosis, the technology of bioimaging using nanomaterials has attracted more and more attention. Bioimaging techniques mainly include optical imaging, nuclear magnetic resonance imaging, ultrasound imaging and positron imaging. The current fluorescence imaging (Fluorescence Imaging, FI) has high sensitivity and short detection time, mainly using organic fluorescent dyes or inorganic fluorescent nanomaterials for contrast imaging. Traditional organic fluorescent dyes are prone to photobleaching and have poor stability. Their excitation peaks are narrow. Specific organic dyes require excitation light of specific wavelengths to be excited. The emission peaks are asymmetrical in width, severely tailed or ov...

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Problems solved by technology

[0005] In order to solve the problems of insufficient sensitivity of MRI imaging and insufficient deep tissue imaging of fluorescence imaging, as well as the low quantum yield of current gadolinium-doped zinc oxide products, the present invention provides a gadolinium-doped zinc oxide with dual-function imaging of magnetic resonance and fluorescence The preparation method of zinc nanoparticles, using the sol-gel method, can directly synthesize gadolinium-doped zinc oxide nanoparticles with uniform size and good dispersion

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