Content detection method of D-sodium erythorbate
A sodium erythorbate and detection method technology, which is applied in the field of content detection of D-sodium erythorbate, achieves the effects of simple operation, low detection cost and good reproducibility
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Embodiment 1
[0021] 1. Chromatographic conditions and system suitability test:
[0022] Agilent 1260Infinity High Performance Liquid Chromatography (Agilent, USA); Agilent Diode Array Detector; Chromatographic Column: PROSHELL120EC-C18 (3.0×50mm2.7 Micron); Mobile Phase: Potassium Dihydrogen Phosphate Solution with a concentration of 0.8% and a pH of 4.0 - Methanol, the volume ratio of the two components is (80:20);
[0023] 2. Selection of detection wavelength
[0024] Accurately weigh 3mg of D-sodium erythorbate reference substance, place it in a 100mL volumetric flask, add pure water to fully dissolve, dilute to the mark, shake well, filter, and use it as the reference substance solution. Use the Agilent autosampler to precisely draw 5 μL and inject it into the liquid chromatograph, and the chromatogram of the component is obtained by the Agilent diode array detector (attached figure 1 ) and UV spectra. From the results of the chromatogram and the ultraviolet spectrogram, it can be s...
Embodiment 2
[0032] 1. Chromatographic conditions and system suitability test:
[0033] Agilent 1260 Infinity High Performance Liquid Chromatography (Agilent, USA); Agilent Diode Array Detector; Chromatographic Column: PROSHELL120EC-C18 (3.0×50mm2.7 Micron); Mobile Phase: Potassium Dihydrogen Phosphate Solution with a concentration of 0.6% and a pH of 4.0 - Methanol, the volume ratio of the two components is (95:5);
[0034] 2. Selection of detection wavelength
[0035] Accurately weigh 3mg of D-sodium erythorbate reference substance, place it in a 100mL volumetric flask, add pure water to fully dissolve, dilute to the mark, shake well, filter, and use it as the reference substance solution. Use the Agilent autosampler to precisely draw 5 μL and inject it into the liquid chromatograph, and the chromatogram of the component is obtained by the Agilent diode array detector (attached figure 1 ) and UV spectra. From the results of the chromatogram and the ultraviolet spectrogram, it can be s...
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