Mirabilitum praeparatum throat-soothing dropping pill and preparation method thereof

A technology of watermelon cream and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problems of thermal instability of aspartame, poor roundness of dripping pills, and large differences in pill weight, etc. problems, to achieve the effect of solving thermal instability, small difference in pellet weight, and high yield

Inactive Publication Date: 2014-04-09
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The object of the present invention is to provide a new Watermelon Frost Moisturizing Throat Pill and its preparation method. The invention selects stevioside as the flavoring agent, which solves the problem of thermal instability of aspartame in the prior art.
In addition, the weight of the dropping pills of the present invention is small, the difference in the weight of the pills is small, and the roundness of the dropping pills is also better, which solves the problems of the large difference in the weight of the pills and the poor roundness of the dropping pills in the prior art

Method used

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  • Mirabilitum praeparatum throat-soothing dropping pill and preparation method thereof
  • Mirabilitum praeparatum throat-soothing dropping pill and preparation method thereof
  • Mirabilitum praeparatum throat-soothing dropping pill and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] The composition of the prescription: 4.333g of watermelon cream, 0.2g of borneol, 0.333g of peppermint oil, 0.4g of menthol, 19.833g of polyethylene glycol-4000, and 0.4g of stevia, made into 1000 pills in total.

[0037] Preparation method: heat and melt polyethylene glycol-4000; pulverize watermelon cream and stevioside respectively, stir evenly, and add to the molten liquid; mix and dissolve peppermint oil and menthol into a liquid, add to the molten liquid, and stir evenly ; The molten liquid is transferred to the dripping pill machine and dripped into the condensing agent simethicone, wherein the dripper specification is 0.2cm inner diameter and 0.25cm outer diameter, and the dripping speed is 65-75 drops / min. The temperature is 70-75°C, and the drop distance is 2cm; cooling and forming, wherein the temperature at the upper end of the condensation column is 45-50°C, and the temperature at the lower end is 10-15°C; collect the formed drop pills, and use a three-legge...

Embodiment 2

[0039] Prescription composition: watermelon frost 2.0g, borneol 0.05g, peppermint oil 0.1g, menthol 0.1g, polyethylene glycol-400010g, stevia 0.1g, made into 1000 pills in total.

[0040] Preparation method: heat and melt polyethylene glycol-4000; pulverize watermelon cream and stevioside respectively, stir evenly, and add to the molten liquid; mix and dissolve peppermint oil and menthol into a liquid, add to the molten liquid, and stir evenly ; The molten liquid is transferred to the dripping pill machine and dripped into the condensing agent simethicone, wherein the dripper specification is 0.2cm inner diameter and 0.25cm outer diameter, and the dripping speed is 65-75 drops / min. The temperature is 70-75°C, and the drop distance is 2cm; cooling and forming, wherein the temperature at the upper end of the condensation column is 45-50°C, and the temperature at the lower end is 10-15°C; collect the formed drop pills, and use a three-legged centrifuge to remove part of the conden...

Embodiment 3

[0042] The composition of the prescription: 8.0g of watermelon cream, 0.5g of borneol, 0.5g of peppermint oil, 0.6g of menthol, 35g of polyethylene glycol-400035g, and 0.6g of stevia, made into 1000 pills in total.

[0043]Preparation method: heat and melt polyethylene glycol-4000; pulverize watermelon cream and stevioside respectively, stir evenly, and add to the molten liquid; mix and dissolve peppermint oil and menthol into a liquid, add to the molten liquid, and stir evenly ; The molten liquid is transferred to the dripping pill machine and dripped into the condensing agent simethicone, wherein the dripper specification is 0.2cm inner diameter and 0.25cm outer diameter, and the dripping speed is 65-75 drops / min. The temperature is 70-75°C, and the drop distance is 3cm; cooling and forming, wherein the temperature at the upper end of the condensation column is 45-50°C, and the temperature at the lower end is 10-15°C; collect the formed drop pills, and use a three-legged cent...

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Abstract

The invention relates to a traditional Chinese medicine formulation mirabilitum praeparatum throat-soothing dropping pill and a preparation method thereof. The traditional Chinese medicine formulation mirabilitum praeparatum throat-soothing dropping pill comprises the following active pharmaceutical components in parts by weight: 20-80 parts of mirabilitum praeparatum, 0.5-5 parts of borneol, 1-5 parts of dementholized peppermint oil and 1-6 parts of menthol; an auxiliary material comprises the following components in parts by weight: 100-350 parts of polyethylene glycol-4000 and 1-6 parts of steviosin. The invention also relates to the preparation method of the mirabilitum praeparatum throat-soothing dropping pill. The mirabilitum praeparatum throat-soothing dropping pill disclosed by the invention is relatively high in heat stability by selecting the steviosin as a flavoring agent, and can not be decomposed by being heated for a long time, thereby solving the problem of instable heat of aspartame in the prior art; meanwhile, the preparation method disclosed by the invention solves the problem that a dropper is easy to adhere in a dropping process by regulating the matrix ratio, therefore, the preparation process is more suitable for large-scale industrialized production and ensures the smoothness of a production process.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation watermelon frost moisturizing throat dropping pill and an improved preparation method thereof. Background technique [0002] The active ingredients of the drug in the watermelon frost moistening throat drop pill are: watermelon frost, borneol, peppermint oil, and menthol. Watermelon cream is made from the ripe fresh fruit and peel of Cucurbitaceae plant watermelon (Citrullus lanatus (Thunb.) Matsumu.et Nakai). Borneol is a colorless transparent or white translucent flaky crisp crystal. Peppermint oil is the volatile oil extracted from fresh stems and leaves of Mentha haplocalyx Brip. through steam distillation, freezing, and partial debraining. Menthol is a saturated cyclic alcohol obtained from peppermint oil. [0003] About Watermelon Cream Throat Moisturizing Preparation is used for sore throat, hoarseness, sores of the mouth and tongue, acute and chronic pharyngitis, acute tonsi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/20A61K47/26A61P11/04A61P1/02A61J3/06A61K31/045
Inventor 邹节明李建华
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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