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Making method of ultrathin antibiotic hydrogel film

A hydrogel and thin film technology, applied in medical science, metal material coating technology, bandages, etc., can solve difficult problems such as nanoscale film thickness control, and achieve good biocompatibility, operability, and stability Strong, precisely controlled thickness

Inactive Publication Date: 2014-04-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common membrane materials are mainly prepared by fusion film formation and solution film formation, but it is difficult to control the film thickness at the nanoscale

Method used

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  • Making method of ultrathin antibiotic hydrogel film
  • Making method of ultrathin antibiotic hydrogel film
  • Making method of ultrathin antibiotic hydrogel film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Preparation of component A

[0044] Add 12mmol PEG-400 and 6mmol dodecylbishydroxyethylmethylammonium chloride into a 250mL three-necked flask, and dissolve with 70mL dichloromethane. Add 20mmol fumaryl chloride and 36mmol triethylamine dropwise, and react at room temperature for 24 hours. The obtained product is precipitated in cold ether, washed and dried to prepare polyethylene glycol-fumaryl chloride-dodecylbishydroxyethylmethyl ammonium chloride. Such as figure 1 It can be seen from the shown nuclear magnetic spectrum that polyethylene glycol-fumaryl chloride-dodecylbishydroxyethylmethyl ammonium chloride has been prepared by the above method.

[0045] (2) Preparation of Copolymer Solution I

[0046] Prepare 50mM Na with pH=7.4 2 HPO 4 / NaH 2 PO 4 Buffer solution, dissolve 250mg of polyethylene glycol-fumaryl chloride-dodecylbishydroxyethylmethylammonium chloride in 25ml of buffer solution to obtain a copolymer solution I with a concentration of 1%.

[...

Embodiment 2

[0057] The embodiment is the same as that of Example 1, except that in step (5), the substrate is repeated 10 cycles in the copolymer solution I and the copolymer solution II.

Embodiment 3

[0059] The embodiment is the same as that of Example 1, except that in step (5), the substrate is repeated 20 cycles in the copolymer solution I and the copolymer solution II.

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Abstract

The invention discloses a making method of an ultrathin antibiotic hydrogel film. The making method comprises the following steps: mixing a component A with a buffering solution to obtain a copolymer solution I, and mixing a component B with the buffering solution to obtain a copolymer solution II; sequentially immersing a substrate in a concentrated sulfuric acid / hydrogen peroxide mixed solution and a silane coupling agent solution; and taking out the substrate, sequentially immersing the substrate in the copolymer solution I and the copolymer solution II, and repeating the immersion in the copolymer solution I and the copolymer solution II several times to obtain the ultrathin antibiotic hydrogel film. The component A is a polymer with the main chain containing a plurality of double bonds, and the component B is a polymer with the main chain containing a plurality of mercapto groups. The making method has the advantages of no need of a catalyst, rapid implementation under a physiologic condition, and good biocompatibility and maneuverability; and the made hydrogel film has the advantages of stable structure in a saline solution, accurate and controllable thickness, and free regulation of the thickness of the film in nanometer and micrometer scales, and has a good antibiosis effect on Escherichia coli and Staphylococcus aureus.

Description

technical field [0001] The invention relates to the preparation of a hydrogel film, in particular to a preparation method of an ultra-thin antibacterial hydrogel film. Background technique [0002] Traditional hydrogels are colloids with a macroscopic three-dimensional network structure, formed by chemical bonds or physical cross-linking, and have high water absorption and swelling properties. It has both the mobility and fluidity of a liquid and the stability of a solid. Due to their good biocompatibility and multiple stimuli responsiveness, hydrogels have been widely used in the fields of enzyme immobilization, sensors, controlled drug release, tissue engineering, and water resource treatment. The preparation of the gel into a nano-thick ultra-thin film has unique innovative value and far-reaching significance in the functionalization of the material surface. [0003] In the fields of optics, biology, anticorrosion, etc., controlling surface properties is the key to maki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/44C08J7/12C08G81/00C03C17/28C04B41/48C23C22/00
Inventor 朱蔚璞王欢杜红高利龙沈之荃
Owner ZHEJIANG UNIV
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