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Preparation method of magnetic carbon nanotube surface molecular imprinting material

A magnetic carbon nanotube, surface molecular imprinting technology, applied in chemical instruments and methods, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve problems such as difficulty in meeting detection requirements, low selectivity, and complicated operations.

Inactive Publication Date: 2014-04-16
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of traditional solid-phase extraction materials and chromatographic packings is impressive, but there are still many deficiencies and problems, such as low selectivity, complicated operation, and difficulty in meeting the current detection needs. The key to the monitoring and analysis of trace quinolones

Method used

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  • Preparation method of magnetic carbon nanotube surface molecular imprinting material
  • Preparation method of magnetic carbon nanotube surface molecular imprinting material
  • Preparation method of magnetic carbon nanotube surface molecular imprinting material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 0.5 g of multi-walled carbon nanotubes to 160 ml of concentrated HNO with a volume ratio of 1:3 3 - Concentrated H 2 SO 4 In the mixed solution, ultrasonically reacted for 6 hours, filtered under reduced pressure, washed repeatedly with distilled water until neutral, dried in vacuum at 60°C to constant weight, and set aside;

[0029] Add 0.4g of the above-prepared carboxylated carbon nanotubes, 2.4g of ferric chloride, 3.4g of sodium acetate and 34g of sodium acrylate into a mixed solvent consisting of 33.75ml of ethylene glycol and 11.25ml of diethylene glycol, and sonicate for 1h to obtain The black mixed solution was transferred to a reaction kettle made of polytetrafluoroethylene, sealed, and placed in a muffle furnace to react for 10 hours. After the reaction was completed, it was cooled to room temperature, washed several times with methanol and water, and dried in vacuum at 60°C to constant weight, spare;

[0030] Add 1mmol of gatifloxacin and 4mmol of met...

Embodiment 2

[0034] Add 0.5 g of multi-walled carbon nanotubes to 160 ml of concentrated HNO with a volume ratio of 1:3 3 - Concentrated H 2 SO 4 In the mixed solution, ultrasonically reacted for 6 hours, filtered under reduced pressure, washed repeatedly with distilled water until neutral, dried in vacuum at 60°C to constant weight, and set aside;

[0035]Add 0.4g of the above-prepared carboxylated carbon nanotubes, 2.4g of ferric chloride, 3.4g of sodium acetate and 3.4g of sodium acrylate into a mixed solvent consisting of 33.75ml of ethylene glycol and 11.25ml of diethylene glycol, and sonicate for 1h Obtain a black mixed solution, transfer it to a polytetrafluoroethylene reaction kettle, seal it, and place it in a muffle furnace for 10 hours of reaction. After the reaction, cool to room temperature, wash it with methanol and water several times, and dry it in vacuum at 60°C. to constant weight, spare;

[0036] Add 1mmol of norfloxacin and 4mmol of methacrylic acid to 10ml of dimeth...

Embodiment 3

[0040] Add 0.5 g of multi-walled carbon nanotubes to 160 ml of concentrated HNO with a volume ratio of 1:3 3 - Concentrated H 2 SO 4 In the mixed solution, ultrasonically reacted for 6 hours, filtered under reduced pressure, washed repeatedly with distilled water until neutral, dried in vacuum at 60°C to constant weight, and set aside;

[0041] Add 0.4g of the above-prepared carboxylated carbon nanotubes, 2.4g of ferric chloride, 34g of sodium acetate and 3.4g of sodium acrylate into a mixed solvent consisting of 33.75ml of ethylene glycol and 11.25ml of diethylene glycol, and sonicate for 1h to obtain The black mixed solution was transferred to a reaction kettle made of polytetrafluoroethylene, sealed, and placed in a muffle furnace to react for 10 hours. After the reaction was completed, it was cooled to room temperature, washed several times with methanol and water, and dried in vacuum at 60°C to constant weight, spare;

[0042] Add 1mmol ofloxacin and 4mmol methacrylic ...

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Abstract

The invention relates to a preparation method of a magnetic carbon nanotube surface molecular imprinting material. The preparation method comprises three steps of magnetic carbon nanotube preparation, surface molecular imprinting reaction and template molecule elution. The preparation method has simple processes and can be controlled easily. The magnetic carbon nanotube surface molecular imprinting material obtained by the preparation method has a specific recognition function, excellent magnetic properties, high mechanical strength, a high adsorption capacity and fast binding dynamical properties, can be used as an ideal adsorbent or a coating material used in various solid-phase extraction technologies, can also be used for preparation of molecularly imprinted sensors and chips, and has an important meaning for studying specific recognition and high-sensitivity detection on quinolone drugs.

Description

technical field [0001] The invention belongs to the field of new material science, and in particular relates to a preparation method of a molecularly imprinted polymer on the surface of magnetic carbon nanotubes. The composite material has a specific recognition effect on quinolone drugs. Background technique [0002] Molecular imprinting technology is a highly selective separation technology that emerged in the 20th century. The basic idea of ​​this technology is derived from people's understanding of antibody-antigen specificity, and the use of polymer materials with molecular recognition capabilities - molecular imprinting polymerization MIP, a biomimetic technology to separate, screen, and purify compounds, because of its three characteristics of predetermined structure and activity, specific recognition, and wide practicability, and it has strong resistance to harsh environments, good stability, and easy to use With the advantages of long life, it has shown great potent...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F220/06C08F226/06C08F220/56C08K9/02C08K7/00C08K3/04C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 何华肖得力李卉袁丹华戴昊彭军李洁皮埃尔·他目
Owner CHINA PHARM UNIV
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