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Citric acid dehydrogenated calcium ascorbate and preparation method and application thereof

A technology of calcium ascorbate and ascorbic acid, which is applied in the field of biochemical medicine and food, can solve the problems of calcium citrate difficulty, usage restrictions, and difficult absorption by humans and animals, and achieve the effects of facilitating human body absorption, reducing costs, and good market prospects

Inactive Publication Date: 2014-04-23
李玉成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Calcium citrate in the biochemical, pharmaceutical and food markets at home and abroad today, English name: Calcium Citrate, molecular formula: Ca 3 (C 6 h 5 o 7 ) 2 4H 2 O, is a white crystalline powder that has the function of calcium supplementation and bone strengthening. It can be used as a food additive and a medicine for treating osteoporosis, leg cramps, and rickets. However, because calcium citrate is insoluble in water (0.095Ca / 100ml, 25°C), Not easily absorbed by humans and animals, limiting its use

Method used

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  • Citric acid dehydrogenated calcium ascorbate and preparation method and application thereof

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Embodiment 1

[0028] The preparation method flowchart of hydrogen citrate calcium ascorbate is as figure 1 shown.

[0029] The preparation method of hydrogen citrate calcium ascorbate of the present embodiment comprises the following steps:

[0030] (1) Weigh 420.28g of citric acid monohydrate, 176.13g of ascorbic acid, 222.24g of calcium hydroxide and a certain amount of water, and put the raw materials into the reaction kettle together;

[0031] (2) Start the chemical reaction for half an hour, the chemical reaction formula is:

[0032] 2(C 6 h 8 o 7 )·H 2 O+C 6 h 8 o 6 +3Ca(OH) 2 = Ca 3 H(C 6 h 7 o 6 )(C 6 h 5 o 7 ) 2 ·3H 2 O↓+5H 2 O, the reaction condition is normal temperature;

[0033] (3) Shut down for half an hour, add ethanol to make the chemical reaction mature, and precipitate calcium hydrogen citrate ascorbate crystals;

[0034] (4) Turn on the machine for half an hour, then filter and wash the materials in the reactor after the reaction, and release calcium...

Embodiment 2

[0037] The preparation method flowchart of hydrogen citrate calcium ascorbate is as figure 1 shown.

[0038] The preparation method of hydrogen citrate calcium ascorbate of the present embodiment comprises the following steps:

[0039] (1) Weigh 840.56g of citric acid monohydrate, 352.26g of ascorbic acid, 444.48g of calcium hydroxide and a certain amount of water, and put the raw materials into the reaction kettle together;

[0040] (2) Start the chemical reaction for half an hour, the chemical reaction formula is:

[0041] 2(C 6 h 8 o 7 )·H 2 O+C 6 h 8 o 6 +3Ca(OH) 2 = Ca 3 H(C 6 h 7 o 6 )(C 6 h 5 o 7 ) 2 ·3H 2 O↓+5H 2 O, the reaction condition is normal temperature;

[0042] (3) Shut down for half an hour, add ethanol to make the chemical reaction mature, and precipitate calcium hydrogen citrate ascorbate crystals;

[0043] (4) Turn on the machine for half an hour, then filter and wash the materials in the reactor after the reaction, and release calcium...

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Abstract

The invention relates to a new substance citric acid dehydrogenated calcium ascorbate and a preparation method and an application thereof. The preparation method of the citric acid dehydrogenated calcium ascorbate is characterized by comprising the following steps: (1) weighing raw materials, including citric acid monohydrate, ascorbic acid, calcium hydroxide and water, and putting into a reaction kettle, wherein the molar ratio of citric acid monohydrate to ascorbic acid to calcium hydroxide is 2:1:3; (2) starting the machine for chemical reaction for half a hour; (3) shutting down for half an hour and adding ethanol so that the chemical reaction gets mature; (4) starting the machine for half a hour, and releasing citric acid dehydrogenated calcium ascorbate. The citric acid dehydrogenated calcium ascorbate prepared by the invention can easily dissolve in water and is beneficial to the assimilation of human and animals, and can be used as a calcium supplementing Vc bone strengthening antioxidation fresh-keeping agent, a calcium supplementing Vc bone strengthening food additive, and a medicine for treating osteoporosis, leg cramps, stomach illness, bronchitis, pneumonia, liver cancer and hypertension.

Description

technical field [0001] The invention relates to the field of biochemical medicine and food, in particular to calcium hydrogen citrate ascorbate and its preparation method and application. Background technique [0002] Calcium citrate in the biochemical, pharmaceutical and food markets at home and abroad today, English name: Calcium Citrate, molecular formula: Ca 3 (C 6 h 5 o 7 ) 2 4H 2 O, is a white crystalline powder that has the function of calcium supplementation and bone strengthening. It can be used as a food additive and a medicine for treating osteoporosis, leg cramps, and rickets. However, because calcium citrate is insoluble in water (0.095Ca / 100ml, 25°C), It is not easily absorbed by humans and animals, so its use is limited. [0003] The main function of ascorbic acid (abbreviated as Vc, also known as vitamin C) is to improve immunity, prevent cancer, heart disease, stroke, protect teeth and gums, etc. The reductive properties of Vc can eliminate the nitros...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/62C07C59/265C07C51/41A61K31/375A61K31/194A23L1/29A61P35/00A61P19/10A61P39/06A61P19/08A61P9/12A61P11/00A23L33/00
CPCC07D307/62A23L33/15A23V2002/00A23V2200/30A23V2200/308A23V2200/306A23V2200/314A23V2200/326
Inventor 李玉成
Owner 李玉成
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