Encapsulated polar materials and methods of preparation

Abstract

The present invention meets one or more of the above needs and relates to a composition comprising plurality of capsules. The capsules comprise: a core of one or more highly polar liquids; one or more polar active materials dissolved in or dispersed in one or more highly polar liquids; a mixture of one or more polymers and one of more highly polar liquids; or a mixture of one or more polymers, one or more highly polar liquids and one or more polar active materials; and a shell comprising, particles in a polymer matrix or particles, wherein the thickness of the shell is sufficient to prevent passage of the highly polar liquid or the active material through the shell or to control the rate passage of the highly polar liquid or the active material through the shell with the proviso that the one or more polymers may be located in the core, in the polymer matrix of the shell or both.

Description

[0001] priority claim

[0002] This application claims priority to Provisional Application Serial No. 61 / 493,070, filed June 3, 2011, which is hereby incorporated by reference in its entirety. technical field

[0003] The present invention relates to capsules containing a polar substance in the core, particles in the shell and a polymer in one or both of the shell and the core, a process for the preparation of the capsules and the use of such capsules. Background technique

[0004] In many systems that utilize active chemical ingredients to perform a function, it is desirable to control the exposure of one or more active chemical ingredients to other components of the system. The active chemical ingredients react upon contact, and in order to ensure that the ingredients react at the proper time, they must remain isolated until the desired reaction is required. A common approach is to set up the system as a two or more part system where the reactive ingredients are not cont...

Examples

preparation example Construction

[0027] Once a stable emulsion or suspension is formed, the emulsion or suspension is subjected to polymerization conditions to form a polymer, preferably a polymer shell around the highly polar liquid droplets. Polymerization conditions depend on the choice of the polymer used. Any polymer system and associated preparation method that forms a polymer or deposit or that forms the polymer as a shell around a droplet may be used. Exemplary methods include interfacial polymerization, in situ polymerization, anionic polymerization, precipitation of polymers from polar or non-polar phases, and electrostatic deposition, eg, by coacervation or layer-by-layer deposition. Exemplary starting materials for such polymers include: where coacervation methods are used, anionic substances (e.g., gum arabic, sodium alginate, styrene-maleic anhydride copolymer, vinylmethyl ether-maleic anhydride copolymer , starch phthalates, and poly(acrylic acid)); in the case of anionic polymerization, cyano...

Embodiment 1 to 23

[0038] Encapsulation preparation procedure

[0039] Add 1.3pph (percentage) of polyisobutylene (weight average molecular weight 500,000 Daltons) in xylene (30g), 5pph of quaternary ammonium-modified nanoclay in xylene to a 120mL (ml) flat bottom bottle with a magnetic stir bar (0.6g), and a premixed solution of diethylenetriamine (3g) and water (6g). Mix well and then sonicate (4x5 sec) at 50% power (Sonics VCX 500 watt model). The prepared emulsion was stirred at 1500 rpm for 2 minutes. A solution of 0.5 g polymeric methylene diisocyanate in 5.5 g xylene was added using a large pipette. The addition was done quickly (-1 ). This peak was stable overnight, indicating that a barrier had formed between the isocyanate and amine. To dispose of cysts, samples were repeatedly decanted and treated with fresh xylene until no isocyanate peaks were visible by ATR-IR. Figure 4 An optical micrograph of the formed capsule 30 is shown. Nanoclay suspensions were prepared as 5 pph suspe...

Embodiment 23-28

[0050] Examples 23-28 Cyanoacrylate Polymers

[0051] Capsules of the present invention were prepared from cyanoacrylate monomers using the ingredients listed in Table 4 and the procedure outlined below.

[0052] Table 4

[0053] ingredients, in order of addition

[0054] Weigh the solvent into a 60 mL bottle and add a stir bar. An aqueous buffer solution was added and the stir bar stirred at 500 rpm to dissolve or disperse the buffer. The particles were added and the mixture was sonicated at 50% power (4x5 seconds with bottles closed and shaken between cycles). The mixture was stirred at 500 rpm after sonication. The monomers are added. The mixtures were studied using light microscopy and in all examples the morphology of the capsules was visible.

[0001] priority claim

[0002] This application claims priority to Provisional Application Serial No. 61 / 493,070, filed June 3, 2011, which is hereby incorporated by reference in its entirety. technical field

[0003] The present invention relates to capsules containing a polar substance in the core, particles in the shell and a polymer in one or both of the shell and the core, a process for the preparation of the capsules and the use of such capsules. Background technique

[0004] In many systems that utilize active chemical ingredients to perform a function, it is desirable to control the exposure of one or more active chemical ingredients to other components of the system. The active chemical ingredients react upon contact, and in order to ensure that the ingredients react at the proper time, they must remain isolated until the desired reaction is required. A common approach is to set up the system as a two or more part system where the reactive ingredients are not cont...

Examples

preparation example Construction

[0027] Once a stable emulsion or suspension is formed, the emulsion or suspension is subjected to polymerization conditions to form a polymer, preferably a polymer shell around the highly polar liquid droplets. Polymerization conditions depend on the choice of the polymer used. Any polymer system and associated preparation method that forms a polymer or deposit or that forms the polymer as a shell around a droplet may be used. Exemplary methods include interfacial polymerization, in situ polymerization, anionic polymerization, precipitation of polymers from polar or non-polar phases, and electrostatic deposition, eg, by coacervation or layer-by-layer deposition. Exemplary starting materials for such polymers include: where coacervation methods are used, anionic substances (e.g., gum arabic, sodium alginate, styrene-maleic anhydride copolymer, vinylmethyl ether-maleic anhydride copolymer , starch phthalates, and poly(acrylic acid)); in the case of anionic polymerization, cyano...

Embodiment 1 to 23

[0038] Encapsulation preparation procedure

[0039] Add 1.3pph (percentage) of polyisobutylene (weight average molecular weight 500,000 Daltons) in xylene (30g), 5pph of quaternary ammonium-modified nanoclay in xylene to a 120mL (ml) flat bottom bottle with a magnetic stir bar (0.6g), and a premixed solution of diethylenetriamine (3g) and water (6g). Mix well and then sonicate (4x5 sec) at 50% power (Sonics VCX 500 watt model). The prepared emulsion was stirred at 1500 rpm for 2 minutes. A solution of 0.5 g polymeric methylene diisocyanate in 5.5 g xylene was added using a large pipette. The addition was done quickly (-1 ). This peak was stable overnight, indicating that a barrier had formed between the isocyanate and amine. To dispose of cysts, samples were repeatedly decanted and treated with fresh xylene until no isocyanate peaks were visible by ATR-IR. Figure 4 An optical micrograph of the formed capsule 30 is shown. Nanoclay suspensions were prepared as 5 pph suspe...

Embodiment 23-28

[0050] Examples 23-28 Cyanoacrylate Polymers

[0051] Capsules of the present invention were prepared from cyanoacrylate monomers using the ingredients listed in Table 4 and the procedure outlined below.

[0052] Table 4

[0053] ingredients, in order of addition

[0054] Weigh the solvent into a 60 mL bottle and add a stir bar. An aqueous buffer solution was added and the stir bar stirred at 500 rpm to dissolve or disperse the buffer. The particles were added and the mixture was sonicated at 50% power (4x5 seconds with bottles closed and shaken between cycles). The mixture was stirred at 500 rpm after sonication. The monomers are added. The mixtures were studied using light microscopy and in all examples the morphology of the capsules was visible.

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