Self-assembled multi-pulse drug-release device, and preparation method and application thereof
A multi-pulse, self-assembly technology, applied in the direction of pharmaceutical formulations, drug devices, and other medical devices, can solve problems such as complex manufacturing methods, and achieve low cost and simple preparation processes
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Embodiment 1
[0047] Example 1 Preparation of bionic self-assembled multi-pulse drug release device (precipitation ring layer is calcium hydrogen phosphate crystal)
[0048] 1) Weigh a certain amount of gelatin and put it in a container, add double distilled water to fully dissolve, and make a gel solution with a concentration of 1wt% according to the mass volume ratio;
[0049] 2) Mix the above glue solution with calcium nitrate solution with a concentration of 0.01mol / L, the volume ratio is 1:0.5, stir evenly, add a certain volume of glutaraldehyde solution with a mass fraction of 2%, to make the crosslinking degree of gelatin 2% to obtain a mixed cross-linking gel solution;
[0050] 3) Add vitamin C to the above-mentioned mixed cross-linking glue solution. The amount of vitamin C added is 0.5% in terms of weight-to-volume ratio. In the tubular mold, leave a certain space at the mouth of the tube, and let it stand to make it completely solidified;
[0051] 4) Both ends of the above-ment...
Embodiment 2
[0053] Example 2 Preparation of bionic self-assembled multi-pulse drug release device (precipitation ring layer is barium sulfate crystal)
[0054] 1) Weigh a certain amount of sodium silicate and put it in a container, add double distilled water to fully dissolve, and make a glue solution with a concentration of 80wt% according to the mass volume ratio;
[0055] 2) Mix the above glue solution with barium nitrate solution with a concentration of 5mol / L, the volume ratio is 1:2, after mixing evenly, stir for 1 hour to obtain a mixed crosslinking glue solution;
[0056] 3) Add vitamin C to the above mixed cross-linking gel solution. The amount of rifampicin added is 5% in terms of weight to volume ratio. Mix evenly. Draw a certain amount with the syringe. After standing for 1-2 hours, slowly push it into the opening In the spherical mold tube, leave a certain space at the opening, and let it stand to make it completely solidified;
[0057] 4) Take out the above-mentioned comple...
Embodiment 3
[0059] Example 3 Preparation of bionic self-assembled multi-pulse drug release device (precipitation ring layer is calcium hydrogen phosphate crystal)
[0060] 1) Weigh a certain amount of gelatin, put it in a container, add double distilled water to fully dissolve, and make a gel solution with a concentration of 3% according to the mass-volume ratio;
[0061] 2) Mix the above glue solution with calcium chloride solution with a concentration of 0.02mol / L, the volume ratio is 1:1, after mixing evenly, add a certain volume of glutaraldehyde solution with a mass fraction of 1%, and stir for 1 hour to make the gelatin The degree of cross-linking is 1%, and the mixed cross-linking gel solution is obtained;
[0062] 3) Add vitamin C to the above mixed cross-linking glue solution. The amount of vitamin C added is 2% in terms of weight to volume ratio, mix well, draw a certain amount from the syringe, and after standing for 1.5 hours, slowly push it into the openings at both ends In ...
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