Unlock instant, AI-driven research and patent intelligence for your innovation.

Magnesium chromium composition

A composition, chromium-magnesium technology, which is applied in the field of chromium-magnesium compositions and chromium-magnesium compositions for improving insulin resistance, can solve the problems of blocking the pathophysiological basis of diabetes and the unsatisfactory ability to improve insulin resistance, etc., and achieve food environment-friendly, Low processing cost, easy to take effect

Inactive Publication Date: 2014-05-14
QINGDAO UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing compositions for improving insulin resistance are chromium yeast or calcium and magnesium tablets, which need to be prescribed and eaten separately, so the ability to improve insulin resistance is not ideal. Compound combination drugs are used for insulin resistance, fundamentally blocking the pathophysiological basis of diabetes and various metabolic related diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Magnesium chromium composition
  • Magnesium chromium composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] The components by weight percentage of each raw material of the chromium-magnesium composition involved in this embodiment are 30-40% of chromium yeast, 30-40% of magnesium oxide, 5-10% of starch, 5-10% of okra powder, and perilla leaf powder 5-10% and 5-10% of lotus root powder, prepared into tablets, powders or capsule packaging structures by conventional processing technology; the effective content is 0.05-0.16mg of trivalent chromium and 0.05-0.2g of magnesium per gram of composition The okra powder is made of naturally dried okra fruit by crushing to make flour-like natural okra powder; the perilla leaf powder is made of fresh perilla leaves and then conventionally crushed to make flour-like natural perilla powder Leaf powder; lotus root powder adopts natural lotus root powder of commercially available products; chromium yeast, magnesium oxide and starch adopt conventional commercially available products; the above-mentioned raw materials are made into tablet, powde...

Embodiment 2

[0010] In this example, according to the inclusion criteria, exclusion criteria, dropout criteria and exit criteria of insulin resistance, a total of 306 people aged 45-59 were screened, and 120 people were enrolled after signing the informed consent, and randomly divided into the control group (oral placebo) , chromium (160μg / d) group, magnesium (200mg / d) group, and chromium-magnesium (chromium 160μg / d+magnesium 200mg / d) group were intervened for 3 months; the actual effect was tested according to the following procedures:

[0011] 1) Specimen collection and testing: measure height, weight, waist circumference and hip circumference before and after intervention, collect fasting venous blood in the morning and venous blood 2 hours after oral glucose before and after intervention, separate serum, and use Hitachi 7600 automatic biochemical analyzer to detect blood sugar , triglycerides, total cholesterol, and HDL and LDL levels;

[0012] 2) Statistical processing: Observation in...

Embodiment 3

[0015] In this example, the serum insulin level is detected by the chemiluminescence method, and the steady-state model is used to calculate the insulin resistance index IRI (IRI=FBG×FIns / 22.5); the observation index is represented by mean ± standard deviation; the routine use of SPSS17.0 statistical software One-way analysis of variance and t-test analysis, with α=0.05 as the test level; the combined supplementation of chromium and magnesium significantly reduced the levels of fasting blood glucose (FBG) and fasting insulin (Fins), and improved glucose metabolism; , Fins were reduced by 0.37mmol / L (t=6.284, P<0.01), 2.91uIU / ml (t=3.885, P<0.01), which was significantly different from the control group (P<0.05); the combination of chromium and magnesium Supplementation with chromium or magnesium alone has a more pronounced effect on lowering fasting blood sugar than simple supplementation with chromium or magnesium, and the results are significantly different (P<0.05). Combined...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine preparation, and relates to a magnesium chromium composition. The magnesium chromium composition comprises the following raw materials in percentage by weight: 30-40% of chromium yeasts, 30-40% of magnesium oxide, 5-10% of starch, 5-10% of okra powder, 5-10% of folia perillae acutae power and 5-10% of lotus root starch. The composition is prepared into troches and powder or is in a capsule packaging structure by a conventional processing process. The effective content is 0.05-0.16mg of trivalent chromium and 0.05-0.2g of magnesium in the composition per g. The magnesium chromium composition is available in components, simple to take, mature in preparation process, easy to control in preparation method, remarkable in curative effect, free from side effect, safe and reliable, low in processing cost, edible and environmental friendly.

Description

Technical field: [0001] The invention belongs to the technical field of drug preparation, and relates to a chromium-magnesium composition, in particular to a chromium-magnesium composition for improving insulin resistance, which has a significant effect on improving glucose and lipid metabolism of insulin-resistant people. Background technique: [0002] With changes in people's lifestyles (sedentary, lack of exercise, etc.) and dietary structure (fine, high-calorie diets, etc.), the incidence of insulin resistance is increasing year by year. According to research statistics, the incidence of insulin resistance in the Chinese population has reached 25%. Insulin resistance is not only the basis of the onset of type 2 diabetes, but also the main thread running through a variety of metabolic related diseases and the link connecting them. It is the common pathophysiological basis of these diseases. Insulin resistance has become a public health that seriously threatens the health o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/62A61P3/10A61P3/06A61P5/50A23L1/304A61K33/06A23L33/16A23L33/165
Inventor 窦梅宫安静马爱国梁惠韩磊
Owner QINGDAO UNIV